Increased Alleviation of Bone Destruction in Individuals with Rheumatoid Arthritis via the Coinhibition of the METTL3 and YTHDF1 Axis by the Combination of Triptolide and Medicarpin

Engineering, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Structural diversity and biological activities of terpenoids derived from Tripterygium wilfordii Hook. f.

RSC Advances, Год журнала: 2025, Номер 15(16), С. 12594 - 12608

Опубликована: Янв. 1, 2025

Terpenoids, a heterogeneous group of natural products, have garnered considerable attention in the field drug discovery.

Язык: Английский

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Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

ABSTRACT Celastrol (CEL) is a natural pentacyclic triterpenoid demonstrating significant therapeutic properties against various diseases. However, the ambiguity of target information poses challenge in transitioning CEL from traditional remedy to modern pharmaceutical agent. Recently, emerging discovery approaches products have broadened extensive avenues for uncovering comprehensive and promoting its drug development. Herein, diverse strategies are overviewed pharmacological toxicological studies CEL, including chemical proteomics, protein microarray, degradation‐based profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based screening, multi‐omics analysis, hypothesis‐driven confirmation. Dozens targets been identified, which significantly suggests that functions as multi‐target Further interaction analysis frequency collected reveal PRDXs, HMGB1, HSP90, STAT3, PKM2 may serve key CEL. Additionally, this review highlights positive role facilitating CEL‐based combination therapy delivery, essential further advancing clinical applications Efforts identification not only aid unraveling scientific underpinnings multiple effects but also offer crucial insights development drugs.

Язык: Английский

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Nanometer preparation of natural bioactive compounds for treatment of rheumatoid arthritis

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101341 - 101341

Опубликована: Май 1, 2025

Язык: Английский

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