Bioanalysis, Год журнала: 2024, Номер unknown, С. 233 - 273
Опубликована: Янв. 1, 2024
Язык: Английский
Materials & Design, Год журнала: 2023, Номер 234, С. 112336 - 112336
Опубликована: Сен. 19, 2023
Lung cancer is one of the most prevalent tumors with rapid progression and poor prognosis, which badly affects human physical mental health. Although traditional anti-cancer therapies, such as chemotherapy radiation, have demonstrated some degree effectiveness in treating tumors, they remain encumbered by frequent, uncontrollable, large dosage drug administration. Here, we introduced Gefitinib-loaded PLGA microspheres generated from microfluidics for lung therapy. The had a homogeneous shape high loading rate. Studies shown that not only provided greater efficiency sustained release gefitinib but also protected breakdown. results animal experiments showed drug-loaded could achieve or even outperform daily medication less frequency. Therefore, it foreseen will great potential developing therapies cancer.
Язык: Английский
Процитировано
12
Biomaterials, Год журнала: 2024, Номер 313, С. 122757 - 122757
Опубликована: Авг. 16, 2024
Язык: Английский
Процитировано
5
Journal of Personalized Medicine, Год журнала: 2024, Номер 14(7), С. 726 - 726
Опубликована: Июль 4, 2024
Male infertility accounts for approximately 40% of cases. There are many causes male infertility, including environmental factors, age, lifestyle, infections, varicocele, and cancerous pathologies. Severe oligozoospermia, cryptozoospermia, azoospermia (obstructive non-obstructive) identified as severe factor once considered conditions sterility. Today, in vitro fertilization (IVF) techniques the only treatment strategy cases which new methodologies have been developed manipulation spermatozoa to achieve increase success rates. This review is an update techniques, particular sperm selection, emphasizing clinical case-specific methodology. The IVF process related diagnosis, appropriate choice treatment, effective preparation selection. In fact, selecting best guarantee optimal paternal heritage means increasing blastulation, implantation, ongoing pregnancy live birth rates, resulting greater techniques.
Язык: Английский
Процитировано
4
IntechOpen eBooks, Год журнала: 2025, Номер unknown
Опубликована: Янв. 4, 2025
A variety of techniques have been employed in the field sperm selection, including methods based on density, morphological characteristics, motility membrane integrity, and surface charge. Among these techniques, density gradient centrifugation (DGC) method stands out as most prevalent widely utilized today. However, this technique involves steps that linked to oxidative stress subsequent cellular damage. Consequently, alternatives DGC are being continuously developed. The recently developed microfluidic chip has also implemented for selection intracytoplasmic injection (ICSI). presents certain disadvantages must be addressed. This chapter evaluates advantages from past present, with a particular focus devices.
Язык: Английский
Процитировано
0
Journal of Pharmacy And Bioallied Sciences, Год журнала: 2025, Номер unknown
Опубликована: Апрель 17, 2025
A BSTRACT This study describes the disadvantages of centrifugation method along with utilization high-technology sperm separation to overcome infertility. 31-year-old female and a 36-year-old male were presented primary infertility in Maharashtra. The had normal hormonal profiles; however, deoxyribonucleic acid (DNA) fragmentation (SDF) index 46%, which may be due lifestyle factors such as occupational exposure chemicals alcohol use. contribution rise SDF was previously conventional density gradient centrifugation. To reduce SDF, put on two months treatment including modification (stress reduction, diet improvement, exercise, etc.) antioxidants. Following this, separated through LensHooke CA0 device that avoids reduces oxidative stress DNA damage using natural motility-based sorting mechanism. Post-treatment, decreased dramatically 17%. couple became pregnant IUI. case shows effectively lowers while ART outcomes improve. These results highlight should implemented modern, minimally invasive procedures for treatment.
Язык: Английский
Процитировано
0
International Journal of Legal Medicine, Год журнала: 2024, Номер 138(6), С. 2209 - 2227
Опубликована: Июль 12, 2024
Язык: Английский
Процитировано
2
ACS Materials Letters, Год журнала: 2024, Номер 6(10), С. 4412 - 4420
Опубликована: Авг. 26, 2024
The vessel-on-a-chip has shown a significant preponderance in vascular disease research. While the rarely demonstrated effects of endogenous and/or exogenous stimuli on endothelial glycocalyx that plays critical role regulating vessel function. Here, an innovative combined with inverse opal films was developed to investigate integrity and its barrier function under different stimuli. By integrating into chip, we achieved real-time observation vitro. We can be maintained physiological shear stress, further, restoration treated sevoflurane after being destroyed by low stress also confirmed. Thus, it is clear system holds considerable promise for studying mechanisms various diseases provides valuable candidate preclinical drug assessment.
Язык: Английский
Процитировано
2
F&S Reviews, Год журнала: 2024, Номер 5(1), С. 100069 - 100069
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1
Journal of Fluid Mechanics, Год журнала: 2024, Номер 997
Опубликована: Окт. 17, 2024
Understanding the effect of intricate surface wettability conditions on microswimmers is crucial for precisely navigating them across narrow microcirculatory networks. Here, we adopt spherical squirmer model and Navier slip condition to delineate microswimmer locomotion under a Poiseuille flow in slit microchannel. Through combined analytical–numerical approach utilizing bispherical coordinates superposition technique, resolve slip-modulated simultaneous hydrodynamic interaction with substrate boundaries. Phase portraits reveal that significantly alters propulsion mechanisms, destabilizing centreline stable oscillations pullers beyond threshold length. Superhydrophobic surfaces suppress near-wall rheotaxis states but preserve focusing, facilitating slip-assisted directed transport without accumulation. Under strong background flows, subcritical Hopf bifurcation emerges at critical length, transitioning dynamics from coexisting unstable purely behaviour. Contrastingly, pushers, causes transition either or fixed-amplitude oscillations. Increased length reduces repulsion walls by enhancing rotational velocity near walls, whereas it counteracts torque pushers. Three-dimensional analysis trajectories reveals significant role out-of-plane orientation its transitions between different swimming states. The presented regime maps offer parametric combinations specific motion behaviours, guiding development smart microfluidic drug delivery systems preventing biofilm deposition biomedical devices.
Язык: Английский
Процитировано
1
Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0