Опубликована: Янв. 1, 2024
Язык: Английский
Nano-Micro Letters, Год журнала: 2023, Номер 16(1)
Опубликована: Ноя. 30, 2023
Synthetic micromotor has gained substantial attention in biomedicine and environmental remediation. Metal-based degradable composed of magnesium (Mg), zinc (Zn), iron (Fe) have promise due to their nontoxic fuel-free propulsion, favorable biocompatibility, safe excretion degradation products Recent advances metallic shown fast movement complex biological media, efficient cargo delivery biocompatibility. A noteworthy number metal-based micromotors employ bubble utilizing water as fuel generate hydrogen bubbles. This novel feature projected for active vivo drug applications. In addition, understanding the mechanism these is also a key parameter design performance. Its propulsion efficiency life span govern overall performance micromotor. Here we review recent advancements micromotors. Furthermore, describe controlled degradation, delivery, built-in acid neutralization capabilities with versatile biomedical Moreover, discuss micromotors' efficacy detecting destroying pollutants. Finally, address limitations future research directions
Язык: Английский
Процитировано
12
Biomimetics, Год журнала: 2023, Номер 8(7), С. 553 - 553
Опубликована: Ноя. 18, 2023
Macrophages, which are part of the mononuclear phagocytic system, possess sensory receptors that enable them to target cancer cells. In addition, they able engulf large amounts particles through phagocytosis, suggesting a potential “Trojan horse” drug delivery approach tumors by facilitating engulfment drug-hidden macrophages. Recent research has focused on development macrophage-based microrobots for anticancer therapy, showing promising results and clinical applications. this review, we summarize recent microrobot therapy. First, discuss types macrophage cells used in these microrobots, common payloads carry, various targeting strategies utilized guide sites, such as biological, chemical, acoustic, magnetic actuations. Subsequently, analyze applications different treatment modalities, including photothermal chemotherapy, immunotherapy, synergistic combination therapies. Finally, present future outlooks microrobots.
Язык: Английский
Процитировано
9
Advanced Materials Technologies, Год журнала: 2024, Номер unknown
Опубликована: Май 16, 2024
Abstract Biomimetic and biohybrid micro/nano‐structures involve the replication creation of technologies, structures, materials based on biological systems at micrometer nanometer scale. These strategies harness natural principles to develop innovative treatment methods advanced microstructure devices for noninvasive therapies. In this study, a detailed overview fabrication processes, magnetically assisted locomotive techniques, potential applications biomimetic micro/nano‐machines are presented. The latest advancements in actuated such as annelid‐worm‐like microswimmers, jellyfish‐shaped microparticles, fish‐shaped walnut‐shaped micromotors explored. Additionally, magnetic systems, including sunflower seed‐based micro‐perforators, nanomotors extracted from bamboo stem, sperm cell‐based micromotors, bacteria‐based robots, scaffold‐based microrobots, DNA‐based microalgae‐based red blood microswimmers also examined. A thorough investigation behavior these Newtonian fluids, featuring cork‐screw motion, undulatory surface wrinkling traveling wave‐like ciliary stroke motion is discussed. Furthermore, unprecedented developed using minuscule cervical cancer tetrapod hybrid tissue regeneration silk fibroin protein‐based microscale scaffolds, doxorubicin drug delivery mushroom‐based microrobots extensively
Язык: Английский
Процитировано
3
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
Given the high malignancy of liver cancer and liver’s unique role in immune metabolic regulation, current treatments have limited efficacy, resulting a poor prognosis. Hydrogels, soft 3-dimensional network materials comprising numerous hydrophilic monomers, considerable potential as intelligent drug delivery systems for treatment. The advantages hydrogels include their versatile modalities, precision targeting, stimulus response, controlled release, loading capacity, excellent slow-release capabilities, substantial carriers bioactive molecules. This review presents an in-depth examination hydrogel-assisted advanced therapies hepatocellular carcinoma, encompassing small-molecule therapy, immunotherapy, gene utilization other biologics. Furthermore, it examines integration with conventional therapies, including radiation, interventional ultrasound. provides comprehensive overview to enhance therapeutic safety. In conclusion, this addresses clinical implementation therapy future challenges design principles hydrogel-based systems, proposes novel research directions strategies.
Язык: Английский
Процитировано
1
Опубликована: Март 1, 2024
In vitro fertilization (IVF) has revolutionized the field of assisted reproductive technologies (ART) by offering hope to individuals and couples struggling with infertility. Nevertheless, traditional IVF methods are not exempt from drawbacks, such as suboptimal success rates, intrusive procedures, ethical considerations. The introduction micro/nanorobotics in offers a revolutionary chance tackle these difficulties. This paper presents short review utilization IVF, investigating progress manipulation sperm, retrieval oocytes, culture embryos, potential future developments this fast progressing area. discussion, we explore fundamental concepts, advantages, difficulties, possible influence transforming processes enhancing patient outcomes.
Язык: Английский
Процитировано
0
Micromachines, Год журнала: 2024, Номер 15(4), С. 510 - 510
Опубликована: Апрель 10, 2024
In vitro fertilization (IVF) has transformed the sector of assisted reproductive technology (ART) by presenting hope to couples facing infertility challenges. However, conventional IVF strategies include their own set problems such as success rates, invasive procedures, and ethical issues. The integration micro/nanorobotics into provides a prospect address these challenging This article an outline use in specializing advancing sperm manipulation, egg retrieval, embryo culture, capacity future improvements this swiftly evolving discipline. additionally explores challenges obstacles associated with IVF, addition concerns regulatory elements related usage advanced technologies ART. A comprehensive discussion risk safety considerations using techniques is likewise presented. Through exploration, we delve core principles, benefits, challenges, potential impact revolutionizing procedures enhancing affected person outcomes.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0