Inhalation Toxicology,
Год журнала:
2022,
Номер
34(13-14), С. 412 - 432
Опубликована: Ноя. 17, 2022
Over
40%
of
veterans
from
the
Persian
Gulf
War
(GW)
(1990-1991)
suffer
Illness
(GWI).
Thirty
years
since
GW,
exposure
and
mechanism
contributing
to
GWI
remain
unclear.
One
possible
that
has
been
attributed
are
chemical
warfare
agents
(CWAs).
While
there
treatments
for
isolated
symptoms
GWI,
number
respiratory
cognitive/neurological
issues
continues
rise
with
minimum
treatment
options.
This
issue
does
not
only
affect
importantly
these
chronic
multisymptom
illnesses
(CMIs)
also
growing
amongst
who
have
served
in
Afghanistan-Iraq
war.
What
both
wars
common
their
regions
inhaled
exposures.
In
this
review,
we
will
describe
CWA
exposures,
such
as
sarin,
cyclosarin,
mustard
gas
discuss
various
neurocognitive
experienced
by
veterans.
We
bridge
neurological
potential
mechanisms
described
each
provided
most
up-to-date
models
hypotheses.
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
264, С. 115396 - 115396
Опубликована: Авг. 23, 2023
Organophosphorus
flame
retardants
(OPFRs),
including
2-ethylhexyl
diphenyl
phosphate
(EHDPHP),
are
prevalent
in
everyday
life
due
to
their
broad
usage
fields
such
as
healthcare,
electronics,
industry,
and
sports.
These
compounds,
added
polymers
through
physical
mixing,
can
leach
into
the
environment,
posing
a
risk
humans
direct
contact
or
food
chain.
Despite
known
associations
with
health
issues
like
endocrine
disruption,
neurotoxicity,
reproductive
toxicity,
implications
of
perinatal
EHDPHP
exposure
on
both
mothers
offspring
still
unclear.
This
study
aimed
investigate
neuroinflammatory
effects
potential
mitigating
role
inulin.
Pregnant
C57
mice
were
administered
either
corn
oil
control
an
solution
(300
μg/kg
bw/d)
from
gestation
day
7
(GD7)
postnatal
21
(PND21).
Concurrently,
provided
regular
drinking
water
supplemented
1%
We
found
that
significantly
increased
serum
levels
IL-1β,
IL-6,
MDA,
but
decreased
SOD
pups.
reversed
by
inulin
supplementation.
RNA-sequencing
revealed
induced
inflammation
oxidative
stress
TLR4/NF-κB
pathway,
which
was
mitigated
In
conclusion,
ameliorated
EHDPHP-induced
neuroinflammation
offspring,
highlighting
its
therapeutic
role.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Tributyl
phosphate
(TBP)
is
an
emerging
hazardous
material
that
ubiquitous
in
the
environment.
However,
whether
TBP
affects
male
reproductive
system
remains
unknown.
In
this
study,
we
exposed
ICR
mice
and
mouse
spermatocyte
GC-2
cells
to
explore
toxicity
of
TBP.
The
results
revealed
(50
100
mg·kg-1·day-1)
decreased
sperm
count
motility,
damaged
testicular
structure,
induced
apoptosis
after
35
days
oral
gavage.
(10,
50,
200
μM)
inhibited
cell
viability,
apoptosis,
reduced
ratio
BCL2/BAX
24
h
exposure.
triggered
buildup
reactive
oxygen
species
a
reduction
mitochondrial
membrane
potential
within
cells.
addition,
led
gut
microbiota
dysbiosis
metabolic
profile
alterations
increased
abundance
Prevotellaceae,
which
are
negatively
associated
with
motility.
Furthermore,
caused
inflammation,
infiltration
Th17
into
small
intestine,
stimulated
IL-17A
signaling
testes.
conclusion,
via
gut-testis
axis,
oxidative
stress,
offering
fresh
perspectives
on
TBP's
hazards
mammals.
Environment International,
Год журнала:
2024,
Номер
186, С. 108596 - 108596
Опубликована: Март 23, 2024
Organophosphate
flame
retardants
(OPFRs)
have
been
widely
detected
in
multiple
environment
media
and
many
adverse
effects
with
complex
toxicity
mechanisms.
However,
the
early
molecular
responses
to
OPFRs
not
fully
elucidated,
thereby
making
it
difficult
assess
their
risks
accurately.
In
this
work,
we
systematically
explored
point
of
departure
(POD)
biological
pathways
at
genome-wide
level
perturbed
by
14
three
substituents
(alkyl,
halogen,
aryl)
using
a
dose-dependent
functional
genomics
approach
Saccharomyces
cerevisiae
24
h
exposure.
Firstly,
our
results
demonstrated
that
overall
potency
gene
(POD
Thoracic Cancer,
Год журнала:
2024,
Номер
15(24), С. 1805 - 1814
Опубликована: Июль 24, 2024
Organophosphate
flame
retardants
(OPFRs)
are
extensively
distributed
in
our
environment,
prompting
concerns
about
potential
health
hazards,
including
lung
injuries
resulting
from
OPFR
exposure.
