A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness DOI

Angela Cruz‐Hernandez,

Andrew Roney,

Dinesh G. Goswami

и другие.

Inhalation Toxicology, Год журнала: 2022, Номер 34(13-14), С. 412 - 432

Опубликована: Ноя. 17, 2022

Over 40% of veterans from the Persian Gulf War (GW) (1990-1991) suffer Illness (GWI). Thirty years since GW, exposure and mechanism contributing to GWI remain unclear. One possible that has been attributed are chemical warfare agents (CWAs). While there treatments for isolated symptoms GWI, number respiratory cognitive/neurological issues continues rise with minimum treatment options. This issue does not only affect importantly these chronic multisymptom illnesses (CMIs) also growing amongst who have served in Afghanistan-Iraq war. What both wars common their regions inhaled exposures. In this review, we will describe CWA exposures, such as sarin, cyclosarin, mustard gas discuss various neurocognitive experienced by veterans. We bridge neurological potential mechanisms described each provided most up-to-date models hypotheses.

Язык: Английский

Exposure, bioaccumulation, and risk assessment of organophosphate flame retardants in crayfish in the middle and lower reaches of the Yangtze River DOI

Qiuhong Peng,

Lingfeng Peng, Jin Liu

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 168859 - 168859

Опубликована: Ноя. 29, 2023

Язык: Английский

Процитировано

7
Relationship between flame retardants and respiratory health– A systematic review and meta-analysis of observational studies DOI Creative Commons
Sónia D. Coelho, Tiago Maricoto, Luís Taborda‐Barata

и другие.

Environmental Pollution, Год журнала: 2024, Номер 347, С. 123733 - 123733

Опубликована: Март 6, 2024

Chronic respiratory diseases are a dealing cause of death and disability worldwide. Their prevalence is steadily increasing the exposure to environmental contaminants, including Flame Retardants (FRs), being considered as possible risk factor. Despite widespread continuous FRs, role these contaminants in chronic yet not clear. This study aims systematically review association between FRs diseases. Searches were performed using Cochrane Library, MEDLINE, EMBASE, PUBMED, SCOPUS, ISI Web Science (Science Social Index), WHO Global Health Library CINAHL EBSCO. Among initial 353 articles found, only 9 fulfilled inclusion criteria included. No statistically significant increase for with was found therefore there enough evidence support that pose significantly higher development or worsening However, non-significant trend potential hazard asthma rhinitis/rhinoconjunctivitis, particularly considering urinary organophosphate esters (OPEs) TNBP, TPHP, TCEP TCIPP congeners/compounds. Most studies showed predominance moderate bias, global strength low. The limitations here reviewed, hazardous effects herein identified highlights need good quality large-scale cohort which biomarkers should be quantified biological samples.

Язык: Английский

Процитировано

2
Protective effect of hesperidin on malathion-induced ovarian toxicity in mice: The role of miRNAs, inflammation, and apoptosis DOI Creative Commons

Seyedeh Fahimeh Talebi,

Alireza Kooshki,

Mahnaz Zarein

и другие.

Toxicology Reports, Год журнала: 2024, Номер 12, С. 469 - 476

Опубликована: Апрель 17, 2024

Malathion, a widely used organophosphate, is known for its relatively low toxicity and extensive application. However, it has been found to act as female reproductive toxicant by causing oxidative stress, apoptosis, autophagy, hormonal imbalances. Hesperidin, flavonoid belonging the flavanone class, exhibits various beneficial properties such antioxidant anti-inflammatory effects, which can potentially counteract harmful effects. The objective of this study was examine how hesperidin malathion impact expression miRNAs genes linked apoptosis inflammation. Balb/c mice (n=40) were divided into four groups: (20 mg/kg), (3 hesperidin+malathion, control. After 35-day intraperitoneal treatment, sacrificed. left ovaries analyzing miRNA-146a-5p, miRNA-129-3p, miRNA-96-5p, NF-κB, Bax, Bcl-2 through RT-qPCR, well levels several cytokines using ELISA method. right examined histological immunohistochemical techniques H&E NF-κB staining. Malathion exposure led an increased Bax/Bcl-2 ratio, upregulated Bax elevated IFN-γ, IL-2, IL-6, enhanced decreased miRNA-129-3p reduced IL-4 IL-10. Additionally, malathion-exposed exhibited structural abnormalities disrupted architecture, accompanied heightened immunoreactivity. Conversely, treatment with showed capacity detrimental consequences on alleviating or reversing these changes. In conclusion, protective effects against malathion-induced ovarian modulating cytokine production, inflammation, miRNA expression.

Язык: Английский

Процитировано

2
Pulmonary redox imbalance drives early fibroproliferative response in moderate/severe coronavirus disease-19 acute respiratory distress syndrome and impacts long-term lung abnormalities DOI Creative Commons

Chun Xia Yang,

Yuanyuan Tan, Zihao Li

и другие.

Annals of Intensive Care, Год журнала: 2024, Номер 14(1)

Опубликована: Май 12, 2024

COVID-19-associated pulmonary fibrosis remains frequent. This study aimed to investigate redox balance in COVID-19 ARDS patients and possible relationship with long-term lung abnormalities. Baseline data, chest CT scores, N-terminal peptide of alveolar collagen III (NT-PCP-III), transforming growth factor (TGF)-β1, superoxide dismutase (SOD), reduced glutathione (GSH), oxidized (GSSG) malondialdehyde (MDA) bronchoalveolar lavage fluid (BALF) were first collected compared between SARS-CoV-2 RNA positive moderate severe (n = 65, ARDS) negative non-ARDS requiring mechanical ventilation 63, non-ARDS). Then, correlations fibroproliferative (NT-PCP-III TGF-β1) markers analyzed within group, comparisons survivor non-survivor subgroups performed. Finally, follow-up survivors was performed analyze the abnormalities, 3 months after discharge. Compared group had significantly elevated scores (p < 0.001) NT-PCP-III 0.001), TGF-β1 GSSG MDA concentrations on admission, while decreased SOD GSH levels observed BALF. Both BALF from directly correlated inversely 0.001). Within non-survivors 28) showed significant fibroproliferation more imbalance than 37). Furthermore, according data 37), radiographic residual function impairment improved discharge associated early 0.01). Pulmonary occurring drives response increases risk death. Long-term abnormalities post-COVID-19 are imbalance.

Язык: Английский

Процитировано

2
A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness DOI

Angela Cruz‐Hernandez,

Andrew Roney,

Dinesh G. Goswami

и другие.

Inhalation Toxicology, Год журнала: 2022, Номер 34(13-14), С. 412 - 432

Опубликована: Ноя. 17, 2022

Over 40% of veterans from the Persian Gulf War (GW) (1990-1991) suffer Illness (GWI). Thirty years since GW, exposure and mechanism contributing to GWI remain unclear. One possible that has been attributed are chemical warfare agents (CWAs). While there treatments for isolated symptoms GWI, number respiratory cognitive/neurological issues continues rise with minimum treatment options. This issue does not only affect importantly these chronic multisymptom illnesses (CMIs) also growing amongst who have served in Afghanistan-Iraq war. What both wars common their regions inhaled exposures. In this review, we will describe CWA exposures, such as sarin, cyclosarin, mustard gas discuss various neurocognitive experienced by veterans. We bridge neurological potential mechanisms described each provided most up-to-date models hypotheses.

Язык: Английский

Процитировано

11