Rational
regulation
of
reactive
oxygen
species
(ROS)
plays
a
vital
importance
in
maintaining
homeostasis
living
biological
systems.
For
ROS-related
pathologies,
chemotherapy
technology
derived
from
metal
nanomaterials
currently
occupies
pivotal
position.
However,
they
suffer
inherent
issues
such
as
complicated
synthesis,
batch-to-batch
variability,
high
cost,
and
potential
toxicity
caused
by
elements.
Here,
we
reported
for
the
first
time
that
dual-action
3,5-dihydroxy-1-ketonaphthalene-structured
small-molecule
enzyme
imitator
(DHKNase)
exhibited
2-edged
ROS
regulation,
catering
to
execution
physiology-beneficial
destiny
among
diverse
pathologies
Based
on
this,
DHKNase
is
validated
enable
remarkable
therapeutic
effects
2
classic
disease
models,
including
pathogen-infected
wound-healing
model
dextran
sulfate
sodium
(DSS)-caused
inflammatory
bowel
(IBD).
This
work
provides
guiding
landmark
developing
novel
natural
significantly
expands
their
application
biomedical
field.
Toxicological Sciences,
Год журнала:
2023,
Номер
194(2), С. 138 - 152
Опубликована: Май 23, 2023
Abstract
The
existence
of
thousands
per-
and
polyfluoroalkyl
substances
(PFAS)
evidence
that
some
cause
adverse
health
effects
has
created
immense
need
to
better
understand
PFAS
toxicity
move
beyond
one-chemical-at-a-time
approaches
hazard
assessment
for
this
chemical
class.
zebrafish
model
enables
rapid
large
libraries
PFAS,
powerful
comparison
compounds
in
a
single
vivo
system,
evaluation
across
life
stages
generations,
led
significant
advances
research
recent
years.
focus
review
is
assess
contemporary
findings
regarding
toxicokinetics,
apical
outcomes,
potential
modes
action
using
the
model.
Much
peer-reviewed
literature
focused
on
small
subset
structural
subclasses,
such
as
perfluoroalkyl
sulfonic
acids
carboxylic
acids.
However,
data
more
diverse
structures
are
enabling
prioritization
concern.
Structure-activity
comparisons
utilization
modeling
‘omics
technologies
have
greatly
contributed
our
understanding
growing
number
will
surely
inform
predictive
capabilities
many
future.
Environment International,
Год журнала:
2024,
Номер
186, С. 108582 - 108582
Опубликована: Март 16, 2024
Perfluoroalkyl
and
polyfluoroalkyl
substances
(PFASs)
are
synthetic
chemicals,
encompassing
compounds
like
perfluorooctane
sulfonate
(PFOS),
which
have
widespread
applications
across
various
industries,
including
food
packaging
firefighting.
In
recent
years,
China
has
increasingly
employed
6:2
Cl-PFESA
as
an
alternative
to
PFOS.
Although
the
association
between
PFAS
exposure
hepatocellular
carcinoma
(HCC)
been
demonstrated,
underlying
mechanisms
that
promote
HCC
proliferation
uncleared.
Therefore,
we
aimed
investigate
effects
differences
of
PFOS
on
through
in
vivo
vitro
tumor
models.
Our
results
reveal
both
significantly
contribute
vivo.
Exposure
led
reduced
population
doubling
times,
enlarged
cell
colony
sizes,
enhanced
DNA
synthesis
efficiency,
a
higher
proportion
cells
undergoing
mitosis.
Furthermore,
Cl-PFES)
shown
activate
PI3K/AKT/mTOR
signaling
pathway
inhibit
necroptosis.
This
action
consequently
enhances
cells.
phenotypic
assay
findings
suggest
tumorigenic
potential
surpasses
PFOS;
subcutaneous
model
using
nude
mice,
mean
weight
for
Cl-PFESA-treated
cohort
was
2.33
times
observed
(p
<
0.01).
Despite
being
considered
safer
substitute
PFOS,
pronounced
this
chemical
growth
warrant
thorough
assessment
hepatotoxicity
risks
linked
its
usage.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(11), С. 4904 - 4913
Опубликована: Март 4, 2024
The
Yangtze
River
fishery
resources
have
declined
strongly
over
the
past
few
decades.
One
suspected
reason
for
decline
in
productivity,
including
silver
carp
(Hypophthalmichthys
molitrix),
has
been
linked
to
organophosphate
esters
(OPEs)
contaminant
exposure.
In
this
study,
adverse
effect
of
OPEs
on
lipid
metabolism
captured
from
was
examined,
and
our
results
indicated
that
muscle
concentrations
were
positively
associated
with
serum
cholesterol
total
levels.
vivo
laboratory
revealed
exposure
environmental
significantly
increased
triglyceride,
cholesterol,
Lipidome
analysis
further
confirmed
dysfunction
induced
by
OPEs,
glycerophospholipids
sphingolipids
most
affected
lipids.
Hepatic
transcriptomic
found
caused
significant
alterations
transcription
genes
involved
metabolism.
Pathways
homeostasis,
peroxisome
proliferator-activated
receptor
(PPAR)
signal
pathway,
metabolism,
fatty
acid
biosynthesis,
steroid
changed.
Furthermore,
affinities
different,
but
11
tested
could
bind
PPARγ,
suggesting
disrupt
interacting
PPARγ.
Overall,
study
highlighted
harmful
effects
wild
fish
provided
mechanistic
insights
into
OPE-induced
metabolic
disorders.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Sodium
p-perfluorous
nonenoxybenzenesulfonate
(OBS)
as
a
novel
surrogate
for
perfluorooctanesulfonate
(PFOS)
has
been
extensively
utilized
in
industrial
manufacturing
and
daily
life.
However,
studies
on
OBS-induced
environmental
health
risks
of
obstructive
biosynthesis
are
currently
limited,
particularly
the
risk
thyroid
diseases.
Following
construction
vivo
(mouse)
vitro
(normal
human
primary
thyrocytes)
models
subchronic
low-dose
OBS
exposure,
we
explored
thyroid-disrupting
effects
through
multiomics
approaches
experimental
validations.
Our
results
showed
that
exposure
to
low
doses
led
hypothyroidism
mice,
presenting
with
reduced
number
functional
abnormalities
thyrocytes.
Further
assays
confirmed
disulfidptosis,
newly
discovered
form
programmed
cell
death,
Meanwhile,
remarkably
suppressed
hormone
synthesis
pathways
mouse
The
charted
multiomic
landscape
mammals
revealed
toxicity
endocrine-disrupting
properties
OBS,
suggesting
it
is
not
safe
alternative
PFOS.
