Natural Flavonoid-Derived Enzyme Mimics DHKNase Balance the Two-Edged Reactive Oxygen Species Function for Wound Healing and Inflammatory Bowel Disease Therapy DOI Creative Commons
Guangfu Feng, Huaizu Zhang, Huipeng Liu

и другие.

Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

Rational regulation of reactive oxygen species (ROS) plays a vital importance in maintaining homeostasis living biological systems. For ROS-related pathologies, chemotherapy technology derived from metal nanomaterials currently occupies pivotal position. However, they suffer inherent issues such as complicated synthesis, batch-to-batch variability, high cost, and potential toxicity caused by elements. Here, we reported for the first time that dual-action 3,5-dihydroxy-1-ketonaphthalene-structured small-molecule enzyme imitator (DHKNase) exhibited 2-edged ROS regulation, catering to execution physiology-beneficial destiny among diverse pathologies Based on this, DHKNase is validated enable remarkable therapeutic effects 2 classic disease models, including pathogen-infected wound-healing model dextran sulfate sodium (DSS)-caused inflammatory bowel (IBD). This work provides guiding landmark developing novel natural significantly expands their application biomedical field.

Язык: Английский

The untold story of PFAS alternatives: Insights into the occurrence, ecotoxicological impacts, and removal strategies in the aquatic environment DOI
Naima Hamid, Muhammad Junaid, Marriya Sultan

и другие.

Water Research, Год журнала: 2023, Номер 250, С. 121044 - 121044

Опубликована: Дек. 23, 2023

Язык: Английский

Процитировано

45

Insights into the circadian rhythm alterations of the novel PFOS substitutes F-53B and OBS on adult zebrafish DOI
Qiyu Wang, Xueyan Gu, Yu Liu

и другие.

Journal of Hazardous Materials, Год журнала: 2023, Номер 448, С. 130959 - 130959

Опубликована: Фев. 8, 2023

Язык: Английский

Процитировано

28

Interactive effects of polystyrene nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonates on the histomorphology, oxidative stress and gut microbiota in Hainan Medaka (Oryzias curvinotus) DOI
Dandan Gao,

Chunmiao Kong,

Hongping Liao

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 880, С. 163307 - 163307

Опубликована: Апрель 6, 2023

Язык: Английский

Процитировано

24

Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity DOI Creative Commons
Yvonne Rericha, Michael T. Simonich, Lisa Truong

и другие.

Toxicological Sciences, Год журнала: 2023, Номер 194(2), С. 138 - 152

Опубликована: Май 23, 2023

Abstract The existence of thousands per- and polyfluoroalkyl substances (PFAS) evidence that some cause adverse health effects has created immense need to better understand PFAS toxicity move beyond one-chemical-at-a-time approaches hazard assessment for this chemical class. zebrafish model enables rapid large libraries PFAS, powerful comparison compounds in a single vivo system, evaluation across life stages generations, led significant advances research recent years. focus review is assess contemporary findings regarding toxicokinetics, apical outcomes, potential modes action using the model. Much peer-reviewed literature focused on small subset structural subclasses, such as perfluoroalkyl sulfonic acids carboxylic acids. However, data more diverse structures are enabling prioritization concern. Structure-activity comparisons utilization modeling ‘omics technologies have greatly contributed our understanding growing number will surely inform predictive capabilities many future.

Язык: Английский

Процитировано

24

Evidence of promoting effects of 6:2 Cl-PFESA on hepatocellular carcinoma proliferation in humans: An ideal alternative for PFOS in terms of environmental health? DOI Creative Commons
Jiawei Hong,

Keyi Du,

Hangbiao Jin

и другие.

Environment International, Год журнала: 2024, Номер 186, С. 108582 - 108582

Опубликована: Март 16, 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are synthetic chemicals, encompassing compounds like perfluorooctane sulfonate (PFOS), which have widespread applications across various industries, including food packaging firefighting. In recent years, China has increasingly employed 6:2 Cl-PFESA as an alternative to PFOS. Although the association between PFAS exposure hepatocellular carcinoma (HCC) been demonstrated, underlying mechanisms that promote HCC proliferation uncleared. Therefore, we aimed investigate effects differences of PFOS on through in vivo vitro tumor models. Our results reveal both significantly contribute vivo. Exposure led reduced population doubling times, enlarged cell colony sizes, enhanced DNA synthesis efficiency, a higher proportion cells undergoing mitosis. Furthermore, Cl-PFES) shown activate PI3K/AKT/mTOR signaling pathway inhibit necroptosis. This action consequently enhances cells. phenotypic assay findings suggest tumorigenic potential surpasses PFOS; subcutaneous model using nude mice, mean weight for Cl-PFESA-treated cohort was 2.33 times observed (p < 0.01). Despite being considered safer substitute PFOS, pronounced this chemical growth warrant thorough assessment hepatotoxicity risks linked its usage.

Язык: Английский

Процитировано

12

Hepatic injury and ileitis associated with gut microbiota dysbiosis in mice upon F–53B exposure DOI Creative Commons
Shen-Pan Li,

LuYin Wu,

HuiXian Zeng

и другие.

Environmental Research, Год журнала: 2024, Номер 248, С. 118305 - 118305

Опубликована: Фев. 1, 2024

Язык: Английский

Процитировано

11

Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River DOI
Chunsheng Liu, Zihan Zhang,

Boqun Li

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(11), С. 4904 - 4913

Опубликована: Март 4, 2024

The Yangtze River fishery resources have declined strongly over the past few decades. One suspected reason for decline in productivity, including silver carp (Hypophthalmichthys molitrix), has been linked to organophosphate esters (OPEs) contaminant exposure. In this study, adverse effect of OPEs on lipid metabolism captured from was examined, and our results indicated that muscle concentrations were positively associated with serum cholesterol total levels. vivo laboratory revealed exposure environmental significantly increased triglyceride, cholesterol, Lipidome analysis further confirmed dysfunction induced by OPEs, glycerophospholipids sphingolipids most affected lipids. Hepatic transcriptomic found caused significant alterations transcription genes involved metabolism. Pathways homeostasis, peroxisome proliferator-activated receptor (PPAR) signal pathway, metabolism, fatty acid biosynthesis, steroid changed. Furthermore, affinities different, but 11 tested could bind PPARγ, suggesting disrupt interacting PPARγ. Overall, study highlighted harmful effects wild fish provided mechanistic insights into OPE-induced metabolic disorders.

Язык: Английский

Процитировано

10

Investigation of the Mechanisms of Liver Injury Induced by Emamectin Benzoate Exposure at Environmental Concentrations in Zebrafish: A Multi-Omics Approach to Explore the Role of the Gut-Liver Axis DOI
Jie Gu,

Yuehong Shen,

Liguo Guo

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138008 - 138008

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1

Multiomic Landscape of Primary Hypothyroidism Induced by Subchronic Exposure to Low-Dose Novel PFOS Substitute OBS in Human and Murine Models DOI
Yang Wang,

Ke Ma,

Supeng Yin

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) as a novel surrogate for perfluorooctanesulfonate (PFOS) has been extensively utilized in industrial manufacturing and daily life. However, studies on OBS-induced environmental health risks of obstructive biosynthesis are currently limited, particularly the risk thyroid diseases. Following construction vivo (mouse) vitro (normal human primary thyrocytes) models subchronic low-dose OBS exposure, we explored thyroid-disrupting effects through multiomics approaches experimental validations. Our results showed that exposure to low doses led hypothyroidism mice, presenting with reduced number functional abnormalities thyrocytes. Further assays confirmed disulfidptosis, newly discovered form programmed cell death, Meanwhile, remarkably suppressed hormone synthesis pathways mouse The charted multiomic landscape mammals revealed toxicity endocrine-disrupting properties OBS, suggesting it is not safe alternative PFOS.

Язык: Английский

Процитировано

1

Sorption and mechanisms of legacy and emerging per- and polyfluoroalkyl substances (PFASs) on different particle size fractions of marine sediments DOI
Junjie Hu, S. C. M. Yu,

Chao Yin

и другие.

Environmental Research, Год журнала: 2025, Номер unknown, С. 121643 - 121643

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

1