Association between exposure to outdoor artificial light at night during pregnancy and glucose homeostasis: A prospective cohort study
Environmental Research,
Год журнала:
2024,
Номер
247, С. 118178 - 118178
Опубликована: Янв. 13, 2024
Язык: Английский
Long-term exposure to ambient ozone at workplace is positively and non-linearly associated with incident hypertension and blood pressure: longitudinal evidence from the Beijing-Tianjin-Hebei medical examination cohort
BMC Public Health,
Год журнала:
2023,
Номер
23(1)
Опубликована: Окт. 16, 2023
There
is
limited
longitudinal
evidence
on
the
hypertensive
effects
of
long-term
exposure
to
ambient
O3.
We
investigated
association
between
O3
at
workplace
and
incident
hypertension,
diastolic
blood
pressure
(DBP),
systolic
(SBP),
pulse
(PP),
mean
arterial
(MAP)
in
general
working
adults.We
conducted
a
cohort
study
by
recruiting
over
30,000
medical
examination
attendees
through
multistage
stratified
cluster
sampling.
Participants
completed
standard
questionnaire
comprehensive
examination.
Three-year
concentrations
each
employed
participant's
were
estimated
using
two-stage
machine
learning
model.
Mixed-effects
Cox
proportional
hazards
models
linear
mixed-effects
used
examine
effect
hypertension
parameters,
respectively.
Generalized
additive
mixed
explore
non-linear
concentration-response
relationships.A
total
16,630
hypertension-free
participants
baseline
finished
follow-up.
The
(SD)
was
45.26
(2.70)
ppb.
cumulative
incidence
7.11
(95%
CI:
6.76,
7.47)
per
100
person-years.
Long-term
independently,
positively
non-linearly
associated
with
(Hazard
ratios
CI)
for
Q2,
Q3,
Q4
1.77
(1.34,
2.36),
2.06
(1.42,
3.00)
3.43
(2.46,
4.79),
respectively,
as
compared
first
quartile
(Q1)),
DBP
(β
0.65
(0.01,
1.30)
Q1),
SBP
2.88
(2.00,
3.77),
2.49
(1.36,
3.61)
2.61
(1.64,
3.58)
Q4,
respectively),
PP
2.12
2.87),
2.03
(1.18,
2.87)
2.14
(1.38,
2.90)
MAP
1.39
(0.76,
2.02),
1.04
(0.24,
1.84)
1.12
(0.43,
1.82)
respectively).
associations
robust
across
sex,
age,
BMI,
when
considering
PM2.5
NO2.To
our
knowledge,
this
population
that
demonstrates
exposure.
findings
are
particularly
relevant
policymakers
researchers
involved
pollution
public
health,
supporting
integration
reduction
into
health
interventions.
Язык: Английский
Habitual night sleep duration is associated with general obesity and visceral obesity among Chinese women, independent of sleep quality
Frontiers in Public Health,
Год журнала:
2023,
Номер
11
Опубликована: Янв. 23, 2023
Purpose
Research
on
the
relationship
between
sleep
duration
and
obesity
defined
using
multiple
anthropometric
bioelectrical
indices
in
women
remains
scarce.
We
aimed
to
explore
association
body
mass
index
(BMI),
waist-hip
ratio
(WHR),
fat
percentage
(PBF)
visceral
area
(VFA)
among
females.
Methods
recruited
for
medical
examination
multistage
cluster
sampling.
Sleep
was
assessed
Pittsburgh
Quality
Index
(PSQI)
categorized
into
short
(<7
h),
optimal
(7
<9
h)
long
(≥
9
h).
Weight
height
were
measured
a
calibrated
stadiometer.
Waist
circumference
manually
measured.
PBF,
VFA
estimated
by
impedance
analysis.
Data
sociodemographic
characteristics
lifestyle
factors
also
collected
included
logistic
regression
models
independent
different
indices.
Results
A
total
of
7,763
with
mean
age
42.6
±
13.5
years
included.
The
reporting
10.3
13.4%
respectively.
BMI,
WHR,
PBF
23.07
3.30
kg/m
2
,
0.78
0.06,
32.23
6.08%
91.64
35.97cm
Short
independently
associated
35%
(95%
CI:
1.05–1.75)
increased
odds
general
(BMI
≥
28
kg/cm
),
18%
1.01–1.37)
(VFA
>
100
cm
).
No
observed
deprivation
or
excessive
high
WHR
PBF.
Conclusion
In
women,
an
obesity,
whereas
obesity.
Longitudinal
observations
are
needed
confirm
this
cross-sectional
relationship.
Язык: Английский
The causal relationship between air pollution, obesity, and COVID-19 risk: a large-scale genetic correlation study
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 5, 2023
Objective
Observational
evidence
reported
that
air
pollution
is
a
significant
risk
element
for
numerous
health
problems,
such
as
obesity
and
coronavirus
disease
2019
(COVID-19),
but
their
causal
relationship
currently
unknown.
Our
objective
was
to
probe
the
between
pollution,
obesity,
COVID-19
explore
whether
mediates
this
association.
Methods
We
obtained
instrumental
variables
strongly
correlated
pollutants
[PM2.5,
nitrogen
dioxide
(NO
2
)
oxides
(NOx)],
9
obesity-related
traits
(abdominal
subcutaneous
adipose
tissue
volume,
waist-to-hip
ratio,
body
mass
index,
hip
circumference,
waist
class
1-3,
visceral
volume),
phenotypes
(susceptibility,
hospitalization,
severity)
from
public
genome-wide
association
studies.
used
clinical
genetic
data
different
biological
databases
performed
analysis
by
two-sample
two-step
Mendelian
randomization.
Results
PM2.5
genetically
with
5
traits,
which
1
most
affected
(beta
=
0.38,
95%
CI
0.11
-
0.65,
p
6.31E-3).
NO
3
also
0.33,
0.055
0.61,
1.90E-2).
NOx
7
1.16,
0.42-1.90,
2.10E-3).
Almost
all
increased
risks
phenotypes.
Among
them,
mediated
effects
of
on
(
<
0.05).
However,
no
direct
observed
COVID-19.
Conclusion
study
suggested
exposure
heavy
causally
obesity.
Besides,
Attention
needs
be
paid
weight
status
population
who
suffer
they
are
more
likely
susceptible
vulnerable
Язык: Английский
Ratio of visceral fat area to body fat mass (VBR) is a superior predictor of coronary heart disease
Chinese Medical Journal,
Год журнала:
2023,
Номер
unknown
Опубликована: Апрель 26, 2023
To
the
Editor:
Cardiovascular
disease
(CVD)
remains
a
leading
cause
of
morbidity
and
mortality
globally,
with
coronary
heart
(CHD)
exhibiting
highest
rate.
Obesity
is
an
important
risk
factor
for
cardiometabolic
complication
CVD.
Visceral
adipose
(VA)
subcutaneous
(SA)
tissues
exert
differential
possibly
opposing
effects
on
cardio-metabolic
outcomes.[1,2]
The
currently
applied
adiposity
indices
are
inefficient
in
predicting
CHD.
Research
which
discriminatory
power
compared
absolute
relative
terms
inadequate,
few
have
men
women
this
regard.
We
performed
anthropometric
bioelectrical
impedance
analysis
(BIA)
measurements
Chinese
adults
proposed
novel
BIA
measurement
—
visceral
fat
area
(VFA)
to
body
mass
(BFM)
ratio
(VBR)
hypothesizing
that
VBR
could
better
assess
cardiovascular
respect
fat.
therefore
assessed
efficacy
then
it
commonly
used
index
(BMI),
waist-to-hip
(WHR),
BFM,
percentage
(PBF),
VFA
identifying
CHD
both
so
as
determine
whether
superior
aforementioned
indices.
analyzed
portion
baseline
data
from
Beijing–Tianjin–Hebei
(BTH)
Medical
Examination
Cohort,
was
conducted
by
recruiting
undergoing
annual
medical
examination
BTH
region
China
September
2018
January
2020.[3]
Individuals
who
were
pregnant,
state
physical
infection,
had
implanted
pacemakers,
or
not
stand
independently
excluded.
Our
study
protocol
approved
Ethics
Review
Boards
Nankai
University
(No.
NKUIRB2016063).
Height
weight
measured
using
same
device
(GL-310,
Seoul,
Korea),
waist
hip
circumferences
manually.
determined
PBF,
multifrequency
plethysmograph
body-composition
analyzer
(Inbody-770,
Korea).
Participants
instructed
fast
8–10
h
engage
strenuous
activity
before
following
morning's
measurements.
A
standard
questionnaire
collect
participants'
age,
sex,
ethnicity,
educational
level
achieved,
marital
status,
occupation,
personal,
family
history
CHD,
alcohol
drinking,
tobacco
smoking,
exercise.
All
professional
staff
methods.[4,5]
Statistical
analyses
Package
Social
Sciences
(SPSS),
version
24.0
(SPSS
Inc.,
Chicago,
IL,
USA)
MedCalc
(MedCalc
Software,
Mariakerke,
Belgium).
Considering
sex
differences
distribution
prevalence,
all
statistical
stratified
sex.
Normally
distributed
continuous
variables
presented
mean
±
deviation
(SD)
t
tests,
while
normally
described
medians
interquartile
ranges
applying
rank-sum
test.
Categorical
numbers
percentages
chi-squared
exploited
multivariate
logistic
regression
relationships
between
adjusting
level,
consumption,
exercise,
disease.
Before
analysis,
standardized
(i.e.,
we
took
original
data,
subtracted
average,
divided
SD),
such
odds
ratios
(ORs)
indicated
increase
per
SD.
receiver
operating
characteristic
(ROC)
curve
compare
predictive
validity.
under
ROC
(AUC)
examine
screening
each
index.
Optimal
cutoff
values
Youden
index,
DeLong
method
AUC
indicators
significant.
Two-tailed
P
values<0.05
considered
be
statistically
As
summarized
[Supplementary
Table
1,
https://links.lww.com/CM9/B433],
included
12,060
individuals
aged
20
91
years
median
age
40
(interquartile
range,
32–54)
years,
42.36%
(n
=
5109)
men.
overall
prevalence
2.65%
(320/12,060)
higher
males
than
females
(3.54%
(181/5109)
vs.
2.00%
(139/6951),
<
0.05).
Younger
college
undergraduate
education,
being
single
negatively
associated
(all
0.05),
having
positively
women.
Drinking
patients
reported
engaging
more
exercise
non-CHD
individuals,
discerned
no
significant
ethnicity
smoking
status
regardless
larger
(P
0.001).
Compared
without
those
exhibited
high
VBR,
BMI,
WHR,
0.008
0.001
other
indices)
shown
Figure
adjusted
ORs
regarding
significantly
reference
women,
suggesting
1-SD
increased
sexes
(except
BMI
men).
demonstrated
largest
aOR
(2.00;
95%
confidence
interval
[CI],
1.69–2.37)
females,
followed
descending
order
(1.80;
CI,
1.54–2.10),
PBF
(1.76;
1.47–2.11),
WHR
(1.66;
1.41–1.96),
(1.46;
1.25–1.70),
BFM
(1.42;
1.22–1.65).
among
1.27–1.69),
(1.43;
1.22–1.67),
(1.33;
1.14–1.54),
(1.21;
1.10–1.34),
1.04–1.39).Figure
1:
Standardized
obesity
(A)
CIs
(B)
VFA,
(C)
BFM:
Body
mass;
BMI:
index;
CHD:
Coronary
disease;
ORs:
Odds
ratios;
PBF:
Percentage
fat;
ROC:
Receiver
characteristic;
VBR:
ratio;
VFA:
area;
WHR;
Waist-to-hip
ratio.Supplementary
2,
https://links.lww.com/CM9/B433
1
reveal
possessed
AUCs
>
0.5),
generating
(0.821
0.753,
respectively).
optimal
value
4.84
cm2/kg
sensitivity
specificity
84.89%
65.15%
4.63
76.80%
66.34%
males,
respectively.
second
(0.676
0.745,
However,
outperformed
greater
respectively)
(0.753
0.676,
manifested
lowest
(0.556),
reflected
(0.671).
any
subjects
<0.001).
greatest
across
siginificantly
0.001),
0.01)
0.001)
whereas
0.16).
In
current
study,
established
basis
whole-body
provides
magnitude
total
rather
amount
thus
some
indication
accumulation
human
body.
our
VA
SA
differ
their
differentiation,
apoptotic
mechanisms,
spectrum
surface
receptors,
lipolysis,
lipogenesis,
cytokine
adipokine
secretion.[6]
Researchers
regional
closely
generalized
obesity.
Excessive
strongly
predicts
onset
severity
insulin
resistance
metabolic
syndrome,
does
not.
Intriguingly,
even
lower
fat,
Based
upon
these
findings,
measure
evaluate
its
Numerous
studies
employed
conventional
measures
WC
abdominal
substitutes
measuring
general
obesity,
revealed
associations
cannot
discriminate
muscle
mass,
distinguish
extant
literature
consistently
describe
noted
Although
investigators
ascertained
far
powerful
predictor
CVD
risk,
suggested
ability
varies
different
populations
completely
reliable
thought
research,
although
showed
females.
consistent
previous
studies.[7]
While
tissue
(especially
VA)
common
low-grade
systemic
inflammation,
differs
relatively
less
Moreover,
sympathetic
nervous
system
(SNS)
activation
enhances
inflammatory
response.
men,
SNS
activated
but
tissue,
either
may
explain
factors
summary,
most
robust
offer
clinical
prevention.
additional
prospective
needed
validate
causal
relationship
Funding
This
supported
grant
Key
Development
Program
2016YFC0900604)
Ministry
Science
Technology.
Conflicts
interest
None.
Язык: Английский
Associations between maternal periconceptional exposure to PM2.5 and the risk of cryptorchidism: a case-control study of 4274
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 29, 2024
Currently,
there
is
limited
evidence
regarding
the
association
between
prenatal
exposure
to
environmental
fine
particulate
matter
(PM2.5)
and
occurrence
of
cryptorchidism.
The
objective
this
study
was
evaluate
potential
correlation
PM2.5
likelihood
cryptorchidism
developing
in
offspring.
We
performed
a
1:1
case–control
study,
defining
cases
as
children
diagnosed
with
at
Children's
Hospital
Affiliated
Chongqing
Medical
University
from
2013
2017,
while
control
group
comprised
born
corresponding
years
who
did
not
have
any
birth
defects,
chromosomal
abnormalities,
had
only
trauma-related
treatments.
Between
2012
monthly
averages
PM2.5,
other
pollutants
(O3,
PM10)
temperature
were
gathered
based
on
geographical
coordinates
patients'
residences.
assessed
two
using
multivariate
logistic
regression
model,
sensitivity
analysis
conducted
assess
stability
model.
included
total
2137
matched
controls
2017.
Our
findings
revealed
that
positive
during
first
2
months
pregnancy
According
development
appears
be
associated
maternal
early
pregnancy.
Язык: Английский
Long-term Exposure to Ambient Ozone at Workplace is Positively and Non-linearly Associated with Incident Hypertension and Blood Pressure: Longitudinal Evidence from the Beijing-Tianjin-Hebei Medical Examination Cohort
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 7, 2023
Abstract
Background
There
is
limited
longitudinal
evidence
on
the
hypertensive
effects
of
long-term
exposure
to
ambient
O
3
.
We
investigated
association
between
at
workplace
and
incident
hypertension,
diastolic
blood
pressure
(DBP),
systolic
(SBP),
pulse
(PP),
mean
arterial
(MAP)
in
general
working
adults.
Methods
analyzed
data
Beijing-Tianjin-Hebei
Medical
Examination-based
Cohort,
which
recruited
over
30,000
medical
examination
attendees
through
multistage
stratified
cluster
sampling.
Participants
completed
a
standard
questionnaire
comprehensive
examination.
Three-year
concentrations
each
employed
participant's
were
estimated
using
two-stage
machine
learning
model.
Mixed-effects
Cox
proportional
hazards
models
linear
mixed-effects
used
examine
effect
hypertension
parameters,
respectively.
Generalized
additive
mixed
explore
non-linear
concentration-response
relationships.
Results
A
total
16,630
hypertension-free
participants
baseline
finished
follow-up.
The
(SD)
was
45.26
(2.70)
ppb.
cumulative
incidence
7.11
(95%
CI:
6.76,
7.47)
per
100
person-years.
Long-term
independently,
positively
non-linearly
associated
with
(Hazard
ratios
CI)
for
Q2,
Q3,
Q4
1.77
(1.34,
2.36),
2.06
(1.42,
3.00)
3.43
(2.46,
4.79),
respectively,
as
compared
first
quartile
(Q1)),
DBP
(
0.65
(0.01,
1.30)
Q1),
SBP
2.88
(2.00,
3.77),
2.49
(1.36,
3.61)
2.61
(1.64,
3.58)
Q4,
respectively),
PP
2.12
2.87),
2.03
(1.18,
2.87)
2.14
(1.38,
2.90)
MAP
1.39
(0.76,
2.02),
1.04
(0.24,
1.84)
1.12
(0.43,
1.82)
respectively).
associations
robust
across
sex,
age,
BMI,
when
considering
PM
2.5
NO
2
Sex
BMI
interacted
ozone,
ozone
having
greater
deleterious
males,
overweight
obese
individuals.
Conclusions
To
our
best
knowledge,
this
cohort
study
population
that
demonstrates
exposure.
Язык: Английский