Ex vivo and in vitro methods as a platform for studying anthropogenic effects on marine mammals: four challenges and how to meet them DOI Creative Commons
Juan Manuel Vázquez, Jane Khudyakov, Carla Bonetti Madelaire

и другие.

Frontiers in Marine Science, Год журнала: 2024, Номер 11

Опубликована: Окт. 11, 2024

Marine mammals are integral to global biodiversity and marine health through their roles in coastal, benthic, pelagic ecosystems. face escalating threats from climate change, pollution, human activities, which perturb oceanic environment. The diverse biology extreme adaptations evolved by make them important study subjects for understanding anthropogenic pressures on However, ethical logistical constraints restrict the tractability of experimental research with live mammals. Additionally, studies effects changing ocean environments further complicated intricate gene-environment interactions across populations species. These obstacles can be overcome a comprehensive strategy that involves systems-level approach integrating genotype phenotype using rigorously defined conditions vitro ex vivo . A thorough analysis between genetics exposure will enable robust predictions about how environmental changes affect populations. In this perspective, we discuss four challenges implementing such non-invasive approaches scientific fields international borders: 1) practical limitations experimentation mammals, 2) accessibility relevant tissue samples cell cultures; 3) open access harmonized methods datasets 4) equitable practices. Successful implementation proposed has potential impact inspire new solutions strategies conservation.

Язык: Английский

Bioaccumulation and Potential Endocrine Disruption Risk of Legacy and Emerging Organophosphate Esters in Cetaceans from the Northern South China Sea DOI
Zhenhui Xie, Xiyang Zhang,

Yanqing Xie

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 22, 2024

Despite the increasing health risks shown by continuous detection of organophosphate esters (OPEs) in biota recent years, information on occurrence and potential OPEs marine mammals remains limited. This study conducted first investigation into body burdens 10 traditional (tOPEs) five emerging (eOPEs) cetacean species (n = 84) from northern South China Sea (NSCS) during 2005–2021. All OPEs, except for 2-ethylhexyl diphenyl phosphate (EHDPHP), were detected these cetaceans, indicating their widespread NSCS. Although levels ∑10tOPEs humpback dolphins remained stable 2005 to 2021, concentrations ∑5eOPEs showed a significant increase, suggesting growing demand new-generation China. Dolphins proximity urban regions generally exhibited higher OPE than those rural areas, mirroring environmental trends occurring this area. congeners, EHDPHP, maternal transfer ratio >1, that dolphin placenta may not be an efficient barrier OPEs. The observed correlations between hormones (triiodothyronine, thyroxine, testosterone) indicated exposures might have endocrine disruption effects population.

Язык: Английский

Процитировано

17
Endocrine-Disrupting Chemical Exposure Induces Adverse Effects on the Population Dynamics of the Indo-Pacific Humpback Dolphin DOI

Dingyu Luo,

Yongwei Guo, Zhiwei Liu

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(21), С. 9102 - 9112

Опубликована: Май 16, 2024

Cetaceans play a pivotal role in maintaining the ecological equilibrium of ocean ecosystems. However, their populations are under global threat from environmental contaminants. Various high levels endocrine-disrupting chemicals (EDCs) have been detected cetaceans South China Sea, such as Indo-Pacific humpback dolphins Pearl River Estuary (PRE), suggesting potential health risks, while impacts endocrine disruptors on dolphin population remain unclear. This study aims to synthesize dynamics PRE and profiles EDC contaminants 2005 2019, investigating EDCs dolphins. Our comprehensive analysis indicates sustained decline population, posing significant risk extinction. Variations sex hormones induced by exposure could potentially impact birth rates, further contributing decline. Anthropogenic activities consistently emerge most stressor, ranking highest importance. Conventional demonstrate more pronounced compared emerging compounds. Among conventional pollutants, DDTs take precedence, followed zinc chromium. The impactful identified alkylphenols. Notably, profile changes, significance pollutants may give way EDCs, presenting continued challenge viability population.

Язык: Английский

Процитировано

6
First determination of elevated levels of plastic additives in finless porpoises from the South China Sea DOI
Zhenhui Xie, Xiyang Zhang, Fei Liu

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 465, С. 133389 - 133389

Опубликована: Янв. 5, 2024

Язык: Английский

Процитировано

5
Nontarget and suspect screening reveals the presence of multiple plastic-related compounds in polar bear, killer whale, narwhal and long-finned pilot whale blubber from East Greenland DOI Creative Commons
Adam F. Pedersen, Stéphane Bayen, Lan Liu

и другие.

Environmental Pollution, Год журнала: 2024, Номер 357, С. 124417 - 124417

Опубликована: Июнь 21, 2024

The monitoring of legacy contaminants in sentinel northern marine mammals has revealed some the highest concentrations globally. However, investigations into presence chemicals emerging Arctic concern (CEACs) and other lesser-known are rarely conducted, if at all. Here, we used a nontarget/suspect approach to screen for thousands different chemicals, including many CEACs plastic-related compounds (PRCs) blubber/adipose from killer whales (Orcinus orca), narwhals (Monodon monoceros), long-finned pilot (Globicephala melas), polar bears (Ursus maritimus) East Greenland. 138 were tentatively identified mostly as PRCs, four confirmed using authentic standards: di(2-ethylhexyl) phthalate (DEHP), diethyl (DEP), di(2-propylheptyl) (DPHP), one antioxidant (Irganox 1010). Three nonylphenol isomer, 2,6-di-tert-butylphenol, dioctyl sebacate, exhibited fragmentation patterns matching those library databases. While phthalates only above detection limits bear narwhal, Irganox 1010, nonylphenol, 2,6-di-tert-butylphenol detected >50% all samples. This study represents first application screening cetaceans, leading identification multiple PRCs their blubber. Further nontarget analyses warranted comprehensively characterize extent CEAC PRC contamination within food webs.

Язык: Английский

Процитировано

5
Plastic ingestion by two cetacean groups: Ziphiidae and Delphinidae DOI
Sergio López‐Martínez, Esther Giménez Luque, José Luis Molina-Pardo

и другие.

Environmental Pollution, Год журнала: 2023, Номер 333, С. 121932 - 121932

Опубликована: Июнь 17, 2023

Язык: Английский

Процитировано

10
Cetaceans as bio-indicators revealed the increased risks of triclosan exposure and associated thyroid hormone disruption during the COVID-19 pandemic DOI
Yongwei Guo, Wei Shi, Zhiwei Liu

и другие.

Journal of Hazardous Materials, Год журнала: 2023, Номер 459, С. 132289 - 132289

Опубликована: Авг. 12, 2023

Язык: Английский

Процитировано

10
Clearing the path: Unraveling bisphenol a removal and degradation mechanisms for a cleaner future DOI
Sourav Kundu, Basanta Kumar Das,

Abhilash Wodeyar

и другие.

Journal of Environmental Management, Год журнала: 2024, Номер 373, С. 123558 - 123558

Опубликована: Дек. 18, 2024

Язык: Английский

Процитировано

4
Exposure and potential risks of thirteen endocrine- disrupting chemicals in pharmaceuticals and personal care products for breastfed infants in China DOI Creative Commons

Yuyan Ji,

Yawen Tian,

Yitao Pan

и другие.

Environment International, Год журнала: 2024, Номер 192, С. 109032 - 109032

Опубликована: Сен. 23, 2024

Язык: Английский

Процитировано

3
Toxic Effects of Bisphenol A on L. variegatus and A. punctulata Sea Urchin Embryos DOI Creative Commons

Jacob D. Kunsman,

Maya C. Schlesinger,

Elizabeth R. McCain

и другие.

Hydrobiology, Год журнала: 2025, Номер 4(1), С. 5 - 5

Опубликована: Фев. 19, 2025

Bisphenol A, BPA, is a small molecule frequently used in large-scale plastic production. The chemical has garnered reputation for its association with harmful human health effects, and numerous animal studies have contributed to classification as an endocrine disruptor. Prior research investigated the impact of on echinoderms, including seven species sea urchin. Our project toxic effects this two uninvestigated species: Lytechinus variegatus Arbacia punctulata. We exposed embryos range environmentally relevant BPA concentrations (1 µg/L, 10 100 1000 µg/L) 48 h, until pluteus stage. Larvae were classified according type abnormality they exhibited, using light microscope, EC50 was determined through probit analysis dose–response curves. also examined isolated plutei skeletons under scanning electron microscope assess changes skeletal structure increasing BPA. results suggest induces embryotoxicity soft tissue abnormalities more severely L. variegatus, whereas A. punctulata exhibits resistance these effects. values, over µg/L approximately 260 support this. These relative values agree our hypothesis that urchin single genus similar level embryotoxicity. Interestingly, SEM examination, microstructure appears be altered result exposure. While EC50s are below what been documented many, but not all, marine environments, longer consistent exposure may deleterious impact. findings BPA’s echinoderms should further explored multiple forms long term.

Язык: Английский

Процитировано

0
Fin Whale as a Sink of Legacy and Emerging Contaminants: First Integrated Chemical Exposomics and Gene Expression Analysis in Cetaceans DOI
María Cristina Fossi, Giacomo Limonta, Matteo Baini

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Июнь 2, 2025

Cetaceans face numerous anthropogenic chemical stressors in global oceans, yet there is a lack of studies that simultaneously assess their cumulative exposure to both legacy and emerging contaminants combined effects. To evaluate the susceptibility fin whale (Balaenoptera physalus) pollution, this study employed for first time multidiagnostic molecular approach integrates exposomics gene expression analysis live-sampled skin blubber biopsies from two distinct populations: endangered Mediterranean subpopulation (Italy) vulnerable population Sea Cortez (Mexico). Both marine regions are biodiversity hotspots characterized by different impacts, making them ideal assessment heterogeneous Results revealed profiles populations, with whales exhibiting higher concentrations pollutants such as polychlorinated biphenyls (PCBs), well plasticizers, perfluoroalkyl substances (PFAS), while populations showed traces pharmaceuticals lifestyle-related chemicals (e.g., paracetamol, diclofenac, nicotine, UV filters) other not previously reported whales. Supported 32 network correlations relevant transcriptional regulation, endocrine disruption, lipid homeostasis, inflammation, our findings suggest complex exposures may compromise health reproductive viability whales, affirming importance sentinel species, which reflects ecosystem integrity within "One Health" framework.

Язык: Английский

Процитировано

0