Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)

Environmental Health, Год журнала: 2023, Номер 22(1)

Опубликована: Фев. 22, 2023

Abstract Background Per- and polyfluoroalkyl substances (PFAS) are of public health concern, because their ubiquitous extremely persistent occurrence, depending on structure, bio-accumulative, mobile toxic properties. Human effects associated with exposure to PFAS include adverse the immune system. In 2020, EFSA (the European Food Safety Authority) defined system as most critical effect for human risk assessment, based reduced antibody responses childhood vaccines similar observed in experimental animal studies. Likewise, U.S. EPA (Environmental Protection Agency) considers PFAS-induced immunotoxicity, especially children, assessment. However, mechanisms by which concentrations impacted not completely understood. Furthermore, other targets functions have been reported literature. Objective The aim this review is explore PFAS-associated immune-related effects. This includes, relevant that may underlie system, immunosuppression well immunoenhancement, such i) modulation cell signalling nuclear receptors, NF-κB PPARs; ii) alteration calcium homoeostasis cells; iii) populations; iv) oxidative stress v) impact fatty acid metabolism & secondary Methods A literature research was conducted using three databases (Web Science, PubMed, Scopus), were searched July 2021 studies published time frame from 2018 2021. total, 487 publications identified potentially eligible following expert-based judgement, articles induced immunotoxicity discussed. Conclusions Taken together, we show there substantial evidence both vitro vivo epidemiological studies, supporting various PFAS, only PFOA PFOS, affect multiple aspects Timing critical, developing vulnerable insults, resulting a higher particularly but also organs later life.

Язык: Английский

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An integrated assessment of ecological and human health risks of per- and polyfluoroalkyl substances through toxicity prediction approaches

The Science of The Total Environment, Год журнала: 2023, Номер 905, С. 167213 - 167213

Опубликована: Сен. 18, 2023

Язык: Английский

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The EU’s Per- and Polyfluoroalkyl Substances (PFAS) Ban: A Case of Policy over Science

Toxics, Год журнала: 2023, Номер 11(9), С. 721 - 721

Опубликована: Авг. 22, 2023

The proposal by the European Chemicals Agency (ECHA) to ban over 12,000 per- and polyfluoroalkyl substances (PFAS) has sparked a debate about potential consequences for economy, industry, environment. Although some PFAS are known be harmful, blanket may lead significant problems in attempting replace PFAS-based materials environmental transition, as well medical devices everyday products. Alternative potentially less safe, rush would reduce time needed toxicological analyses. Studies have shown that exhibit diverse range of mechanisms action, biopersistence, bioaccumulation potential, should thus not treated single group. This is particularly true class fluoropolymers. A targeted approach considers specific risks benefits each chemical more effective. Moreover, proposed also unintended environment use associated with such reducing greenhouse-gas emissions improving energy efficiency. Policymakers must carefully weigh up before making final decision on ban.

Язык: Английский

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The “forever” per- and polyfluoroalkyl substances (PFAS): A critical accounting of global research on a major threat under changing regulations

Chemosphere, Год журнала: 2024, Номер 354, С. 141694 - 141694

Опубликована: Март 12, 2024

The European Commission's current efforts to launch the largest proposal restrict per- and polyfluoroalkyl substances (PFAS) in history reflect dire global plight of PFAS accumulation environment their health impacts. While there are existing studies on research, is a lack comprehensive analysis that both covers entire research period provides deep insights into patterns, incentives, barriers based various parameters. We have been able demonstrate increasing interest although citation numbers declining prematurely. Policy regulations proving establishing toxicity PFASs stimulated developed countries vice versa, with emphasis ecological aspects. China, particular, investing increasingly but without defining or implementing - devastating effects. separation industrial environmental interests clear, little involvement developing countries, even though exposure devastating. It, therefore, requires increased globally networked multidisciplinary approaches address contamination challenges.

Язык: Английский

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Advancing toxicity studies of per- and poly-fluoroalkyl substances (pfass) through machine learning: Models, mechanisms, and future directions

The Science of The Total Environment, Год журнала: 2024, Номер 946, С. 174201 - 174201

Опубликована: Июнь 25, 2024

Язык: Английский

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Integrated approaches for immunotoxicity risk assessment: challenges and future directions

Deleted Journal, Год журнала: 2024, Номер 1(1)

Опубликована: Окт. 29, 2024

The integration of immunotoxicity data into chemical risk assessment paradigms is essential for comprehensively evaluating the potential health hazards posed by exposures. This review provides a comprehensive overview methodologies, challenges, and future directions integrating frameworks. It discusses fundamental principles immunotoxicology its relevance to assessment, highlighting critical roles immune system in defense against harmful agents. Next, we explore traditional frameworks, including exposure hazard identification, dose–response characterization, need incorporating endpoints enhance characterization estimation. Subsequently, delve modelling immunotoxicity, elucidating principles, methods, case studies illustrating relationships extrapolation from animal humans. Furthermore, discuss focusing on identification immunotoxic hazards, evaluation endpoints, utilization immunological biomarkers assessment. We then examine cumulative strategies, presenting conceptual framework assessing risks multiple exposures methods different chemicals. Lastly, emerging trends high-throughput screening assays, omics technologies, computational modelling, alternative testing along with regulatory implications research needs. valuable insights researchers, regulators, stakeholders involved public protection, facilitating development evidence-based strategies safeguarding human associated

Язык: Английский

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Identification and quantification of per- and polyfluorinated alkyl substances (PFAS) migrating from food contact materials (FCM)

Chemosphere, Год журнала: 2024, Номер 360, С. 142360 - 142360

Опубликована: Май 16, 2024

Per- and polyfluorinated alkyl substances (PFAS) can be added to food contact materials (FCM) increase their water and/or grease repellent properties. Some well-known PFAS are perfluoroalkyl carboxylic acids (PFCA), sulfonic (PFSA), telomer alcohols (FTOH). Due the strength of carbon-fluorine bond, chemically very stable highly resistant biological degradation, posing a risk human health environment. To examine presence in paper-based FCM, various samples were collected, including popcorn bags, muffin cups, pizza boxes with high total organic fluorine (TOF) content from Danish Spanish markets. The FCM composition was characterised by FTIR. Quantification some such as PFCA, PFSA, FTOH performed simulants using LC-MS/MS, addition non-targeted screening approach LC-Orbitrap-HRMS. Among analysed samples, highest concentrations found cup made cellulose (PFCA ∼ 1.41 μg kg

Язык: Английский

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Dietary exposure to per- and polyfluoroalkyl substances: Potential health impacts on human liver

The Science of The Total Environment, Год журнала: 2023, Номер 907, С. 167945 - 167945

Опубликована: Окт. 21, 2023

Язык: Английский

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Dose additive maternal and offspring effects of oral maternal exposure to a mixture of three PFAS (HFPO-DA, NBP2, PFOS) during pregnancy in the Sprague-Dawley rat

The Science of The Total Environment, Год журнала: 2023, Номер 892, С. 164609 - 164609

Опубликована: Июнь 3, 2023

Язык: Английский

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Tissue-specific distribution and fatty acid content of PFAS in the northern Bohai Sea fish: risk-benefit assessment of legacy PFAS and emerging alternatives

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136024 - 136024

Опубликована: Окт. 5, 2024

Язык: Английский

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