Опубликована: Янв. 1, 2024
Язык: Английский
The Science of The Total Environment, Год журнала: 2024, Номер 919, С. 170716 - 170716
Опубликована: Фев. 5, 2024
Язык: Английский
Процитировано
10
Water Research, Год журнала: 2024, Номер 256, С. 121584 - 121584
Опубликована: Апрель 9, 2024
Язык: Английский
Процитировано
10
Journal of Hazardous Materials, Год журнала: 2025, Номер 486, С. 137127 - 137127
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
1
The Science of The Total Environment, Год журнала: 2023, Номер 901, С. 165879 - 165879
Опубликована: Июль 29, 2023
Язык: Английский
Процитировано
16
The Science of The Total Environment, Год журнала: 2024, Номер 953, С. 175971 - 175971
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
6
ISME Communications, Год журнала: 2023, Номер 3(1)
Опубликована: Апрель 20, 2023
Acinetobacter is present in the livestock environment, but little known about their antibiotic resistance and pathogenic species farm groundwater. Here we investigated of swine groundwater (JZPG) residential (JZG) a farming village, comparison to nearby (3.5 km) non-farming village (WTG) using metagenomic culture-based approaches. Results showed that abundance resistome some JZG all JZPG (~3.4 copies/16S rRNA gene) was higher than WTG (~0.7 gene), indicating influence activities on both types. accounted for ~95.7% bacteria JZPG, only ~8.0% WTG. They were potential hosts ~95.6% affected groundwater, which includes 99 ARG subtypes against 23 classes. These ARGs associated with diverse intrinsic acquired mechanisms, predominant tetracyclines fluoroquinolones genes. Metagenomic binning analysis elucidated non-baumannii including A. oleivorans, beijerinckii, seifertii, bereziniae modestus might pose environmental risks because multidrug resistance, pathogenicity massive existence Antibiotic susceptibility tests isolated strains resistant multiple antibiotics sulfamethoxazole (resistance ratio: 96.2%), levofloxacin (42.5%), gatifloxacin (39.0%), ciprofloxacin (32.6%), tetracycline (32.0%), doxycycline (29.0%) ampicillin (12.0%) as well last-resort polymyxin B (31.7%), colistin (24.1%) tigecycline (4.1%). The findings highlight prevalence groundwater-borne antibiotic-resistant environment.
Язык: Английский
Процитировано
15
Environmental Science & Technology, Год журнала: 2023, Номер 57(48), С. 19965 - 19978
Опубликована: Ноя. 16, 2023
Bioaerosol pollution poses a substantial threat to human health during municipal food waste (FW) recycling. However, bioaerosol-borne antibiotic-resistant genes (ARGs) have received little attention. Herein, 48 metagenomic data were applied study the prevalence of PM2.5-borne ARGs in and around full-scale treatment plants (FWTPs). Overall, FWTP PM2.5 (2.82 ± 1.47 copies/16S rRNA gene) harbored comparable total abundance that wastewater plant (WWTP), but was significantly enriched with multidrug type (e.g., AdeC/I/J; p < 0.05), especially abundant could serve as effective indicators define resistome profiles FWTPs (Random Forest accuracy >92%). exhibited decreasing enrichment along FWTP–downwind–boundary gradient, eventually reaching levels urban (1.46 0.21 gene, N = 12). The combined analysis source-tracking, metagenome-assembled genomes (MAGs), culture-based testing provides strong evidence Acinetobacter johnsonii-dominated pathogens contributed shaping disseminating ARGs, while abiotic factors (i.e., SO42–) indirectly participated these processes, which deserves more attention developing strategies mitigate airborne ARGs. In addition, exposure level resistant about 5–11 times higher than those PM2.5, be severe hospital certain scenarios (<41.53%). This work highlights importance need for re-evaluating air induced by public terms.
Язык: Английский
Процитировано
14
Journal of Hazardous Materials, Год журнала: 2023, Номер 465, С. 133082 - 133082
Опубликована: Ноя. 25, 2023
Язык: Английский
Процитировано
11
iMeta, Год журнала: 2024, Номер 3(1)
Опубликована: Янв. 1, 2024
Abstract Antimicrobial resistance (AMR) is a major threat to global public health, and antibiotic genes (ARGs) are widely distributed across humans, animals, environment. Farming environments emerging as key research area for ARGs resistant bacteria (ARB). While the skin an important reservoir of ARB, transmission mechanisms between farming human remain unclear. Previous studies confirmed that swine farm environmental exposures alter microbiome, but timeline these changes ill defined. To improve understanding determine specific time, we designed cohort study workers students through collected samples explore impact daily occupational exposure in on microbiome. Results indicated livestock‐associated where microorganisms richer than school environment can reshape microbiome resistome. Exposure 5 h was sufficient modify ARG structure workers' by enriching ARGs. These were preserved once formed. Further analysis carried host may transfer with have potential expand general population using vector. results raised concerns about broader community. Therefore, it necessary take corresponding intervention measures production process reduce possibility ARB transmission.
Язык: Английский
Процитировано
4
Antibiotics, Год журнала: 2024, Номер 13(6), С. 565 - 565
Опубликована: Июнь 17, 2024
The understanding of antibiotic resistance, one the major health threats our time, is mostly based on dated and incomplete notions, especially in clinical contexts. “canonical” mechanisms action pharmacodynamics antibiotics, as well methods used to assess their activity upon bacteria, have not changed decades; same applies definition, acquisition, selective pressures, drivers resistance. As a consequence, strategies improve usage overcome resistance ultimately failed. This review gathers most “non-canonical” notions antibiotics resistance: from alternative limitations susceptibility testing wide variety lateral gene transfer mechanisms, ubiquity, societal factors maintaining Only by having “big picture” view problem can adequate harness be devised. These must global, addressing many aspects that drive increasing prevalence resistant bacteria aside use antibiotics.
Язык: Английский
Процитировано
4