American Journal of Epidemiology,
Год журнала:
2024,
Номер
193(12), С. 1729 - 1740
Опубликована: Май 23, 2024
Abstract
Persistent
endocrine-disrupting
chemicals
(EDCs)
can
dysregulate
the
stress
response.
We
evaluated
associations
between
persistent
EDCs
and
perceived
among
participants
in
Study
of
Environment,
Lifestyle,
Fibroids
(n
=
1394),
a
prospective
cohort
study
Black
women.
Participants
completed
Perceived
Stress
Scale
4
(PSS-4)
at
baseline
every
20
months
through
60
(score
range:
0-16);
higher
scores
indicate
stress.
Endocrine-disrupting
chemicals,
including
per-
polyfluoroalkyl
substances,
polychlorinated
biphenyls
(PCBs),
polybrominated
diphenyl
ethers
(PBDEs),
organochlorine
pesticides,
were
quantified
plasma
samples
baseline.
fit
bayesian
kernel
machine
regression
linear
mixed-effects
models
to
estimate
(as
mixture
individually)
with
PSS-4
each
follow-up
visit,
respectively.
Increasing
percentiles
not
strongly
associated
baseline,
no
interactions
observed
EDCs.
Several
individual
(eg,
perfluorodecanoic
acid,
PCB
118,
PBDE
99)
or
follow-up,
other
(eg
138/158)
lower
follow-up.
The
directionality
for
was
inconsistent
across
visits.
In
conclusion,
specific
may
be
This
article
is
part
Special
Collection
on
Environmental
Epidemiology.
Frontiers in Toxicology,
Год журнала:
2024,
Номер
6
Опубликована: Апрель 26, 2024
In
the
European
regulatory
context,
rodent
in
vivo
studies
are
predominant
source
of
neurotoxicity
information.
Although
they
form
a
cornerstone
neurotoxicological
assessments,
costly
and
topic
ethical
debate.
While
public
expects
chemicals
products
to
be
safe
for
developing
mature
nervous
systems,
considerable
numbers
commerce
have
not,
or
only
limited
extent,
been
assessed
their
potential
cause
neurotoxicity.
As
such,
there
is
societal
push
toward
replacement
animal
models
with
vitro
alternative
methods.
New
approach
methods
(NAMs)
can
contribute
knowledge
base,
increase
chemical
safety,
modernize
hazard
risk
assessment.
Provided
reach
an
acceptable
level
relevance
reliability,
NAMs
may
considered
as
replacements
specific
studies.
The
Partnership
Assessment
Risks
from
Chemicals
(PARC)
addresses
challenges
development
implementation
collaboration
agencies,
Project
5.2.1e
(Neurotoxicity)
aims
develop
evaluate
developmental
(DNT)
adult
(ANT)
understand
applicability
domain
detection
endocrine
disruption
epigenetic
perturbation.
To
speed
up
assay
time
reduce
costs,
we
identify
early
indicators
later-onset
effects.
Ultimately,
will
assemble
second-generation
first-generation
test
batteries,
both
which
aim
provide
assessors
industry
stakeholders
robust,
speedy,
lower-cost,
informative
next-generation
assessment
tools.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(20), С. 7866 - 7877
Опубликована: Май 16, 2023
Perfluorooctane
sulfonate
(PFOS),
a
new
type
of
persistent
organic
pollutant
in
the
environment
water,
has
drawn
significant
attention
recent
years
due
to
its
widespread
prevalence
and
high
toxicity.
Neurotoxicity
is
regarded
as
one
major
toxic
effects
PFOS,
while
research
studies
on
PFOS-induced
depression
underlying
mechanisms
remain
scarce.
In
this
study,
behavioral
tests
revealed
depressive-like
behaviors
PFOS-exposed
male
mice.
Neuron
damages
including
pyknosis
staining
deepening
were
identified
through
hematoxylin
eosin
staining.
Then,
we
noticed
elevation
glutamate
proline
levels
well
decline
glutamine
tryptophan
levels.
Proteomics
analysis
105
differentially
expressed
proteins
that
change
dose-dependent
manner
PFOS
exposure
activated
glutamatergic
synapse
signaling
pathway,
which
further
confirmed
by
Western
blot,
data
consistent
with
findings
proteomics
analysis.
Additionally,
downstream
cyclic
AMP-responsive
element-binding
protein
(CREB)/brain-derived
neurotrophic
factor
(BDNF)
synaptic
plasticity-related
postsynaptic
density
95,
synaptophysin,
downregulated.
Our
results
highlight
may
inhibit
plasticity
hippocampus
via
CREB/BDNF
pathway
cause
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
485, С. 136832 - 136832
Опубликована: Дек. 10, 2024
Persistent
organic
pollutants
(POPs)
are
ubiquitous
in
the
environment
and
display
capacity
to
bioaccumulate
living
organisms,
constituting
a
hazard
both
wildlife
humans.
Although
restrictions
have
been
applied
prohibit
production
of
several
POPs
since
1960s,
high
levels
these
compounds
can
still
be
detected
many
environmental
biological
matrices,
due
their
chemical
properties
significantly
long
half-lives.
Some
passed
from
mother
fetus
gain
entry
central
nervous
system
(CNS),
by
crossing
blood-brain
barrier
(BBB),
resulting
significant
deleterious
effects,
including
neurocognitive
psychiatric
abnormalities,
which
may
lead
long-term
socio-economic
burdens.
A
growing
body
evidence
obtained
clinical
experimental
studies
has
increasingly
indicated
that
influence
neurodevelopment
through
cellular
molecular
mechanisms.
However,
assessing
mechanisms
action
incipient,
requiring
further
research.
Polychlorinated
biphenyls
(PCBs)
per-
polyfluoroalkyl
substances
(PFAS)
two
main
classes
associated
with
disturbances
different
human
systems,
mainly
endocrine
systems.
This
narrative
review
discusses
PCB
PFAS
effects
on
CNS,
focusing
neuroinflammation
oxidative
stress
consequences
for
neural
development
BBB
integrity.
Moreover,
we
propose
could
involved
POP-induced
neurodevelopmental
defects.
In
this
sense,
highlight
potential
pathways
affect
explored
preventive
therapies
formulate
public
health
policies.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(19), С. 8264 - 8277
Опубликована: Май 1, 2024
Prenatal
per-
and
poly-fluoroalkyl
substances
(PFAS)
exposure
may
influence
gestational
outcomes
through
bioactive
lipids─metabolic
inflammation
pathway
indicators.
We
estimated
associations
between
prenatal
PFAS
lipids,
measuring
12
serum
50
plasma
lipids
in
414
pregnant
women
(median
17.4
weeks'
gestation)
from
three
Environmental
influences
on
Child
Health
Outcomes
Program
cohorts.
Pairwise
association
estimates
across
cohorts
were
obtained
linear
mixed
models
meta-analysis,
adjusting
the
former
for
false
discovery
rates.
Associations
mixture
using
quantile
g-computation.
analyses
revealed
lipid
levels
associated
with
PFDeA,
PFNA,
PFOA,
PFUdA
(p
<
0.05)
enzymatic
pathways
(cyclooxygenase,
cytochrome
p450,
lipoxygenase)
at
least
one
combined
cohort
analysis,
PFOA
(q
0.2)
model.
The
strongest
signature
doubling
corresponding
PGD2
(cyclooxygenase
pathway;
+24.3%,
95%
CI:
7.3–43.9%)
cohort.
Mixture
analysis
nine
positive
all
mixture,
indicating
a
quartile
increase
(+34%,
8–66%),
primarily
driven
by
PFOS.
Bioactive
emerged
as
biomarkers,
deepening
insights
into
PFAS'
pregnancy
outcomes.
