Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 290, С. 117527 - 117527
Опубликована: Дек. 21, 2024
Язык: Английский
Journal of Hazardous Materials, Год журнала: 2024, Номер 478, С. 135444 - 135444
Опубликована: Авг. 6, 2024
Pharmaceuticals and personal care products (PPCPs) exhibit varying biodegradability during the acidogenic methanogenic phases of anaerobic digestion. However, there is limited information regarding end generated these processes. This work investigates biotransformation (BTPs) in a two-phase (TP) acidogenic-methanogenic (Ac-Mt) bioreactor using advanced suspect nontarget strategies. Fourteen BTPs were confidently identified from ten parent PPCPs including carbamazepine (CBZ), naproxen (NPX), diclofenac (DCF), ibuprofen (IBU), acetaminophen (ACT), metoprolol (MTP), sulfamethoxazole (SMX), ciprofloxacin (CIP), methylparaben (MPB) propylparaben (PPB). These linked with oxidation reactions such as hydroxylation, demethylation epoxidation. Their generation was related to organic acid production, since all metabolites detected acidogenesis, some being subsequently consumed methanogenesis, e.g., aminothiophenol kynurenic acid. Another group showed increased concentrations under conditions, hydroxy-diclofenac epoxy-carbamazepine. The most high removal efficiencies (> 90 %) – SMX, CIP, NPX, MTP, ACT, MPB, PPB, while DCF, CBZ IBU demonstrated higher persistence - DCF (42 %); (40 %), (47 %). phase separation digestion provided deeper understanding pathways PPCPs, addition enhancing persistent compounds, i.e., IBU.
Язык: Английский
Процитировано
6
Chemosphere, Год журнала: 2024, Номер 351, С. 141221 - 141221
Опубликована: Янв. 13, 2024
Suspect and non-target screening (SNTS) methods are being promoted in order to decode the human exposome since a wide chemical space can be analysed diversity of biofluids. However, SNTS approaches exposomics field infra-studied comparison environmental or food monitoring studies. In this work, comprehensive suspect workflow was developed annotate exposome-related xenobiotics phase II metabolites diverse Precisely, urine, breast milk, saliva ovarian follicular fluid were employed as samples by means ultra-high performance liquid chromatography coupled with high resolution tandem mass spectrometry (UHPLC-HRMS/MS). To automate workflow, "peak rating" parameter implemented Compound Discoverer 3.3.2 optimized avoid time-consuming manual revision chromatographic peaks. addition, presence endogenous molecules that might interfere annotation carefully studied employment inclusion exclusion lists. evaluate limits identification (LOIs) type I errors (i.e., false positives negatives, respectively) calculated both standard solutions spiked biofluids using 161 22 metabolites. For 80.3 % suspects, LOIs below 15 ng/mL achieved. terms errors, only two cases identified standards samples. Regarding 7.7 accounted increased 17.4 real Lastly, use an list for endogens favoured it avoided 18.7 potential while caused 7.2 despite making less time-consuming.
Язык: Английский
Процитировано
3
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 180, С. 117903 - 117903
Опубликована: Авг. 9, 2024
Exposure to organic compounds during early-life stages can disrupt human development and increase susceptibility adverse health outcomes later in life. Despite evidence of these impacts, research has primarily focused on targeted analyses, missing the complex nature exposures. Comprehensive approaches are needed better characterize mixtures. Recent advances high-resolution mass spectrometry computational science have enabled comprehensive analysis numerous chemicals through wide-scope screening approaches, yet their application exposome studies is still limited. This review critically examines from past decade using investigate chemical exposome, emphasizing compounds. It evaluates each step analytical workflow, including sample collection, preparation, analysis, data processing, concludes with recommendations for future improve understanding its implications.
Язык: Английский
Процитировано
3
Chinese Journal of Chromatography, Год журнала: 2024, Номер 42(2), С. 109 - 119
Опубликована: Фев. 1, 2024
The occurrence and development of human diseases are influenced by both genetic environmental factors. Research models that describe disease only from the perspective genetics present certain limitations. In recent years, effects environment factors on have attracted extensive attentions. Exposomics focuses measurement all exposure in an individual's life how these related to development. provides new ideas promote studies relationship between health Environmental exposures characterized with different physical chemical properties, as well very low concentrations vivo, which contribute great challenges comprehensive residues body. Chromatography-mass spectrometry-based technologies combine high-efficiency separation ability chromatography high resolution sensitive detection characteristics mass spectrometry; combination techniques can achieve high-coverage, high-throughput, exposures, thus providing a powerful tool for measuring exposures. Exposomics-analysis methods based chromatography-mass spectrometry mainly include targeted quantitative analysis, suspect screening, non-targeted screening. To explore diseases, researchers developed research paradigms, including exposome wide association study, mixed-exposure exposomics multi-omics (genome, transcriptome, proteome, metabolome)-association so on. emergence has brought about unprecedented developments studies. this manuscript, analytical spectrometry, their relevant prospects reviewed.
Язык: Английский
Процитировано
2
The Science of The Total Environment, Год журнала: 2024, Номер 933, С. 172985 - 172985
Опубликована: Май 3, 2024
Язык: Английский
Процитировано
2
The Science of The Total Environment, Год журнала: 2024, Номер 953, С. 176008 - 176008
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
2
The Science of The Total Environment, Год журнала: 2024, Номер 956, С. 177309 - 177309
Опубликована: Ноя. 6, 2024
Язык: Английский
Процитировано
2
Reproductive Toxicology, Год журнала: 2024, Номер 128, С. 108636 - 108636
Опубликована: Июнь 13, 2024
Язык: Английский
Процитировано
1
The handbook of environmental chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12373 - 12373
Опубликована: Ноя. 18, 2024
A total of 16 organic sunscreens and over 160 products their degradation in biotic abiotic conditions were investigated the context safety during pregnancy. Drug-likeness ability studied compounds to be absorbed from gastrointestinal tract cross human placenta predicted silico using SwissADME software (for drug-likeness oral absorption) multiple linear regression "ARKA" models permeability expressed as fetus-to-mother blood concentration state equilibrium), with latter outperforming MLR models. It was established that most can tract. The (expressed a binary descriptor,
Язык: Английский
Процитировано
1