Water,
Год журнала:
2023,
Номер
15(22), С. 3890 - 3890
Опубликована: Ноя. 8, 2023
As
contaminants
are
often
present
in
aquatic
environments
as
mixtures,
they
may
interact
with
each
other
and
affect
living
organisms
differently
than
when
tested
individually.
Emerging
pollutants
such
pharmaceuticals
microplastics
can
be
influenced
by
various
environmental
factors,
UV/Vis
radiation
being
among
the
most
significant.
This
study
aimed
to
evaluate
photodegradation
of
antidepressant
duloxetine
presence
four
types
microplastics.
Acute
toxicity
was
using
Spirotox
assay,
concentration
determined
HPLC-DAD
analysis,
resulting
products
were
HPLC-MS/MS.
Following
1
2
h
exposure
a
sunlight
simulator,
concentrations
decreased
nine
thirteen
times,
respectively,
while
its
protozoa
only
two
three
times.
The
samples
did
not
either
process
or
duloxetine.
HPLC-MS/MS
analysis
revealed
34
products.
In
silico
T.E.S.T.
program
for
protozoan
Tetrahymena
pyriformis
indicated
that
one-third
photoproducts
toxic,
found
much
more
toxic
high
one
these
compounds
confirmed
test.
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
476, С. 135053 - 135053
Опубликована: Июнь 27, 2024
The
presence
of
microplastics
in
cosmetics
and
personal
care
products
(C&PCPs)
has
been
increasingly
the
public
eye
since
early
2010s.
Despite
increasing
research
into
potential
environmental
health
effects
microplastics,
most
to
date
on
C&PCPs
investigated
"rinse-off"
products,
while
impacts
"leave-on"
have
largely
neglected,
despite
these
being
purchased
greater
volumes
often
having
two
or
more
microplastic
ingredients
their
formulations(CosmeticsEurope,
2018b).
This
review
aims
synthesize
current
knowledge
C&PCPs,
assessing
human
discussing
regulatory
implications.
lack
studies
leave-on
is
significant,
suggesting
a
severe
gap
regarding
in,
emissions
from,
C&PCPs.
There
noticeable
(eco)toxicological
consequences
exposure
from
As
result,
significant
aspects
contamination
may
be
overlooked
legislations
emerging
globally
(including
European
Commission),
which
intend
restrict
use
but
focus
rinse-off
only.
highlights
for
decision-making,
particularly
as
alternatives
are
considered
during
phase-out
periods
spotlights
need
sufficient
monitoring
alternatives,
avoid
unforeseen
consequences.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Aged
micro(nano)plastics
(MNPs)
are
normally
the
ultimate
state
of
plastics
in
environment
after
aging.
The
changes
physical
and
chemical
characteristics
aged
MNPs
significantly
influence
their
environmental
behavior
by
releasing
additives,
forming
byproducts,
adsorbing
contaminants.
However,
a
systematic
review
is
lacking
on
effects
ecological
human
health
regarding
increasing
but
scattered
studies
results.
This
Review
first
summarizes
unique
methods
for
quantifying
aging
degree.
Then
we
focused
potential
impacts
organisms,
ecosystems,
health,
including
"Trojan
horse"
under
real
conditions.
Through
combining
meta-analysis
analytic
hierarchy
process
(AHP)
model,
demonstrated
that,
compared
to
virgin
MNPs,
would
result
biomass
decrease
oxidative
stress
increase
organisms
lead
total
N/P
greenhouse
gas
emissions
ecosystems
while
causing
cell
apoptosis,
antioxidant
system
reaction,
inflammation
health.
Within
framework
risk
assessment,
used
quotient
(RQ)
physiologically
based
pharmacokinetic
(PBK)
models
as
examples
illustrate
importance
considering
degree
data
acquisition,
model
building,
formula
evaluation.
Given
risks
our
urgent
call
more
understand
hazards
real-world
environments.
Environmental Science & Technology,
Год журнала:
2023,
Номер
57(48), С. 19341 - 19351
Опубликована: Ноя. 7, 2023
Polystyrene
nanoplastics
(PS-NPs)
are
emerging
environmental
contaminants
that
ubiquitously
detected
in
various
environments
and
have
toxic
effects
on
organisms.
Nevertheless,
the
transgenerational
reproductive
toxicity
underlying
mechanisms
of
PS-NPs
remain
largely
unknown,
especially
for
photoaged
under
ultraviolet
irradiation.
In
this
study,
only
parental
generation
(P0)
was
exposed
to
virgin
aged
at
environmentally
relevant
concentrations
(0.1-100
μg/L),
subsequent
generations
(F1-F4)
were
cultured
normal
conditions.
Ultraviolet
irradiation
induced
persistent
free
radicals
reactive
oxygen
species,
which
altered
physical
chemical
characteristics
PS-NPs.
The
results
testing
suggested
exposure
caused
a
more
severe
decrease
brood
size,
egg
ejection
rate,
number
fertilized
eggs,
hatchability
than
did
P0,
F1,
F2
generations.
Additionally,
single
maternal
resulted
fertility
F1
Increased
levels
H3K4
H3K9
methylation
observed
generations,
concomitant
with
downregulation
expression
associated
genes,
such
as
spr-5,
set-17,
met-2.
On
basis
correlation
analyses,
histone
these
genes
significantly
correlated
effects.
Further
research
showed
not
spr-5(by134),
met-2(n4256),
set-17(n5017)
mutants.
Overall,
via
methylation,
met-2,
set-17
involved
regulation
toxicity.
This
study
provides
new
insights
into
potential
risks
photoaging
environment.
Environment International,
Год журнала:
2024,
Номер
186, С. 108640 - 108640
Опубликована: Апрель 1, 2024
Tire
wear
particles
(TWP)
are
a
prevalent
form
of
microplastics
(MPs)
extensively
distributed
in
the
environment,
raising
concerns
about
their
environmental
behaviors
and
risks.
However,
knowledge
regarding
properties
toxicity
these
at
environmentally
relevant
concentrations,
specifically
role
persistent
free
radicals
(EPFRs)
generated
during
TWP
photoaging,
remains
limited.
In
this
study,
evolution
EPFRs
on
under
different
photoaging
times
adverse
effects
Caenorhabditis
elegans
were
systematically
investigated.
The
process
primarily
resulted
formation
reactive
oxygen
species
(O2•−,
⋅OH,
1O2),
altering
physicochemical
TWP.
exposure
nematodes
to
100
μg/L
TWP-50
(TWP
with
time
50
d)
led
significant
decrease
locomotory
(e.g.,
head
thrashes,
body
bends,
wavelength)
neurotransmitter
contents
dopamine,
glutamate,
serotonin).
Similarly,
expression
neurotransmission-related
genes
was
reduced
exposed
TWP-50.
Furthermore,
addition
free-radical
inhibitors
significantly
suppressed
TWP-induced
neurotoxicity.
Notably,
correlation
analysis
revealed
negative
between
levels
nematodes.
Thus,
it
concluded
that
photoaged
induce
neurotoxicity
by
affecting
neurotransmission.
These
findings
elucidate
mechanisms
EPFRs,
emphasizing
importance
considering
contributions
when
evaluating
risks
associated
