Small Black Phosphorus Disrupts Vascular Development and Hematopoiesis in Zebrafish Larvae

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Май 25, 2025

Black phosphorus (BP), a novel two-dimensional (2D) material, has shown promising applications in the optoelectronic, biological, and medical fields recent years. However, its increasing use may lead to inadvertent environmental release, creating potential ecological health risks that remain poorly understood. In this study, wild-type transgenic zebrafish were used evaluate developmental toxicity of small-size BP (S-BP), with lateral particle size 154.4 ± 34.6 nm, focusing specifically on vascular growth hematopoiesis at relatively low concentrations 0.025, 0.05, 0.1, 0.2 mg/L. The results indicated S-BP adhered chorion induced defects. uninflated swim bladders decreased heart rate observed S-BP-exposed larvae 120 hpf. angioarchitectural profiling using showed exposure adversely impaired blood vessel development 72 hpf, especially common cardinal vein (CCV). Moreover, erythropoiesis flow velocity red cells (RBCs) disturbed hpf all groups. Transcriptomic analysis unveiled altered gene expression related angiogenesis, hematopoiesis, ribosome function, transport processes. Notably, mRNA levels hematopoietic markers, including clec14a, nme2b.1, klf2a, slc2a1a, csf1rb, atf3, scl, scml4, significantly downregulated following exposure. Our findings revealed caused hematologic identified CCV RBCs as sensitive targets. This work expands our understanding 2D nanomaterials provides critical data for risk assessment.

Язык: Английский

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Bioaccumulation and distribution of per- and polyfluoroalkyl substances and organophosphate flame retardants in marine organisms from the Vietnamese coast: Links to species traits and environmental exposure

Marine Pollution Bulletin, Год журнала: 2025, Номер 219, С. 118237 - 118237

Опубликована: Июнь 3, 2025

Язык: Английский

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Deficiency of spns1 exacerbates per- and polyfluoroalkyl substances mediated hepatic toxicity and steatosis in zebrafish (Danio rerio)

Toxicology, Год журнала: 2023, Номер 499, С. 153641 - 153641

Опубликована: Окт. 6, 2023

Язык: Английский

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Triglycerides mediate the relationships of per- and poly-fluoroalkyl substance (PFAS) exposure with nonalcoholic fatty liver disease (NAFLD) risk in US participants

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 289, С. 117436 - 117436

Опубликована: Дек. 4, 2024

Язык: Английский

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Biochemical and transcriptomic analyses reveal the toxicological response and potential mechanism of butyl benzyl phthalate in zebrafish gills

The Science of The Total Environment, Год журнала: 2024, Номер 951, С. 175623 - 175623

Опубликована: Авг. 18, 2024

Язык: Английский

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