Age, gender, and race differences in nasal morphology: Linking air conditioning and filtration efficiency to disparities in air pollution health outcomes and COVID-19 mortality

Chemosphere, Год журнала: 2025, Номер 377, С. 144358 - 144358

Опубликована: Март 29, 2025

Язык: Английский

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Exposure to PM2.5 modulate the pro-inflammatory and interferon responses against influenza virus infection in a human 3D bronchial epithelium model

Environmental Pollution, Год журнала: 2024, Номер 348, С. 123781 - 123781

Опубликована: Март 14, 2024

Язык: Английский

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Particulate matter-induced oxidative stress – mechanistic insights and antioxidant approaches reported in in vitro studies

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 110, С. 104529 - 104529

Опубликована: Авг. 9, 2024

Inhaled particulate matter (PM) is a key factor in millions of yearly air pollution-related deaths worldwide. The oxidative potential PM indicates its ability to promote an environment. Excessive reactive oxygen species (ROS) can cause cell damage via stress, leading inflammation, endoplasmic reticulum airway remodeling, and various death modes (apoptosis, ferroptosis, pyroptosis). ROS also interact with macromolecules, inducing DNA epigenetic modifications, disrupting homeostasis. These effects have been studied extensively vitro confirmed vivo. This review explores the airborne particles PM-induced ROS-mediated cellular observed vitro, highlighting link between described latest literature. analyzes on damage, repair, carcinogenicity, epigenetics. Additionally, developments antioxidants prevent ROS's harmful are described, providing future perspectives topic.

Язык: Английский

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Particulate matter-induced epigenetic modifications and lung complications

European Respiratory Review, Год журнала: 2024, Номер 33(174), С. 240129 - 240129

Опубликована: Окт. 1, 2024

Air pollution is one of the leading causes early deaths worldwide, with particulate matter (PM) as an emerging factor contributing to this trend. PM classified based on its physical size, which ranges from 10 (diameter ≤10 μm) 2.5 (≤2.5 and 0.5 (≤0.5 μm). Smaller-sized can move freely through air readily infiltrate deep into lungs, intensifying existing health issues exacerbating complications. Lung complications are most common arising exposure due primary site deposition in respiratory system. Conditions such asthma, COPD, idiopathic pulmonary fibrosis, lung cancer various infections all susceptible worsening exposure. epigenetically modify specific target sites, further complicating impact these conditions. Understanding epigenetic mechanisms holds promise for addressing cases This involves studying effect different gene expressions regulation modifications, including DNA methylation, histone modifications microRNAs. Targeting manipulating their could be promising strategies future treatments review mainly focuses mentioned above.

Язык: Английский

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Shedding light on the cellular mechanisms involved in the combined adverse effects of fine particulate matter and SARS-CoV-2 on human lung cells

The Science of The Total Environment, Год журнала: 2024, Номер 952, С. 175979 - 175979

Опубликована: Сен. 2, 2024

Airborne pathogens represent a topic of scientific relevance, especially considering the recent COVID-19 pandemic. Air pollution, and particulate matter (PM) in particular, has been proposed as possible risk factor for onset spread pathogen-driven respiratory diseases. Regarding SARS-CoV-2 infection, exposure to fine PM (PM2.5, particles with an aerodynamic diameter < 2.5 μm) associated increased incidence disease. To provide useful insights into mechanisms through which might be involved we exposed human lung cells (A549) PM2.5 SARS-CoV-2, evaluate toxicological properties molecular pathways activated when airborne are combined viral particles. Winter was collected metropolitan urban area its physico-chemical composition analyzed. A549 were concomitantly or after pre-treatment PM2.5. Inflammation, oxidative stress xenobiotic metabolism main investigated. Results showed that 72 h significantly expression angiotensin-converting enzyme 2 (ACE2) receptor, is one keys used by virus infect host cells. We also analyzed endosomal route process internalization, studying RAB5 RAB7. The results show pre-activated then increased. activation inflammatory studied. Our findings increase pro-inflammatory markers (NF-kB IL-8) subsequently further 24 h, demonstrating interaction between determines severity responses epithelial In conclusion, study provides mechanistic biological evidence contribution progression diseases populations.

Язык: Английский

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Health Benefits of Air Pollution Reduction: Evidence From Economic Slowdown in India

Economics & Human Biology, Год журнала: 2024, Номер 55, С. 101437 - 101437

Опубликована: Окт. 17, 2024

Язык: Английский

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Particulate Matter-Induced Oxidative Stress – Recent Mechanistic Insights from In Vitro Studies

Опубликована: Апрель 2, 2024

Inhaled particulate matter (PM) is a key player in the millions of yearly deaths worldwide related to air pollution. The oxidative potential PM provides an indication its ability promote environment. When human lungs are exposed PM, reactive oxygen species (ROS) generated such environment, if excessive, may lead cell damage via stress. Inflammation, endoplasmic reticulum stress, airway remodeling, and many different death modes (apoptosis, ferroptosis, pyroptosis, among others) can be triggered by stress complex molecular pathways, which also involve adaptive cellular response. But ROS directly interact with macromolecules as proteins lipids, well nucleic acids, having been reported induce DNA epigenetic modifications, jeopardizes homeostasis. These facts have extensively studied vitro models confirmed vivo models.In this review, we delve beyond conventional assessments airborne particles, discussing their PM-induced ROS-mediated observed models. close link between inflammation, manifestation highlighted reviewing latest literature. effects on balance repair, carcinogenicity epigenetics interplay then analyzed. Finally, expand reports antioxidants&rsquo; counteract deleterious ROS, disclose future perspectives for topic.

Язык: Английский

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Correlation between Exposure to UFP and ACE/ACE2 Pathway: Looking for Possible Involvement in COVID-19 Pandemic

Toxics, Год журнала: 2024, Номер 12(8), С. 560 - 560

Опубликована: Июль 31, 2024

The overlap between the geographic distribution of COVID-19 outbreaks and pollution levels confirmed a correlation exposure to atmospheric particulate matter (PM) SARS-CoV-2 pandemic. RAS system is essential in pathogenesis inflammatory diseases caused by pollution: ACE/AngII/AT1 axis activates pro-inflammatory pathway, which counteracted ACE2/Ang(1-7)/MAS axis, an anti-inflammatory protective pathway. However, ACE2 also known act as receptor through enters host cells replicate. Furthermore, vivo systems have demonstrated that PM increases expression. In this study, effects acute sub-acute ultrafine particles (UFP), originating from different anthropogenic sources (DEP BB), on ACE2, ACE, COX-2, HO-1, iNOS lungs other organs implicated were analyzed BALB/c male mice model. Exposure UFP alters and/or ACE all examined organs, DEP results release s-ACE2. evidenced our previous works, organ-specific alterations. These proteins play pivotal role UFP-induced oxidative stress responses, their dysregulation linked development severe symptoms individuals infected with SARS-CoV-2, suggesting heightened vulnerability or more clinical course disease. share common pathways; therefore, "risk stratification" concept, daily air may significantly increase likelihood developing form COVID-19, explaining, at least part, greater lethality virus observed highly polluted areas.

Язык: Английский

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Subnational Evidence for the Attributable Burden of Respiratory Infections in China’s Population under 20: Challenges from Particulate Matter Pollution

Environment & Health, Год журнала: 2024, Номер 3(2), С. 177 - 189

Опубликована: Ноя. 7, 2024

Respiratory infections and tuberculosis ranked as the second leading global causes of mortality in 2021. Following methodology from Global Burden Disease Study (GBD) 2021, we aimed to estimate attributable burden risk factors respiratory among China's population under 20 1990 In there were 652 million new cases 12 699 deaths people years old China. We estimated 9054 (71.2%) 818 498 (54.6%) disability-adjusted life (DALYs) attributed all evaluated factors. Mortality rates highest Xizang, Xinjiang, Qinghai while they constantly decreased since 1990. Ambient particulate matter pollution was cause death males first females, accounting for nearly 1/5 23 33 provinces, ambient DALY, Xizang Gansu, it not major contributor burden. From household air declined remarkably provinces except fraction (PAF) continuously increased. The overall showed a declining trend, remained fatal threat infants relatively less developed regions. raised hazard underscored necessity shift into formulation prevention intervention strategies.

Язык: Английский

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Meteorological Conditions and PM2.5 Impact on COVID-19 Case Fatality Ratios (CFR) in Bangkok Metropolitan Region

Deleted Journal, Год журнала: 2024, Номер unknown

Опубликована: Апрель 3, 2024

The emergence of a novel coronavirus strain triggered global health crisis, impacting both and economies worldwide, including Thailand since 2019. While prior research hinted at connections between environmental factors rising COVID-19 cases, these links remained inconclusive. This study investigated indoor outdoor (I/O) ratios explored potential correlations fine particulate matter (PM2.5), meteorological conditions, the case fatality rate (CFR%) in Bangkok its metropolitan area from January to December 2021. In Spearman’s Rank correlation analysis, results found that CFR% exhibited positive with relative humidity (RH) (r=0.187) negative PM2.5 (r=-0.190) wind speed (WS) (r=-0.039). generalized additive model (GAM) indicated RH, PM2.5, temperature, WS adversely affect COVID-19. Consistent relationships were observed GAM model. underscored complexity understanding pandemic dynamics across seasons, I/O ratios, influence lag days. By presenting results, they may serve as valuable reference for planning interventions during future pandemics.

Язык: Английский

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