The Cytotoxic Effects of Fine Particulate Matter (PM2.5) from Different Sources at the Air–Liquid Interface Exposure on A549 Cells

Toxics, Год журнала: 2023, Номер 12(1), С. 21 - 21

Опубликована: Дек. 25, 2023

The health of humans has been negatively impacted by PM2.5 exposure, but the chemical composition and toxicity might vary depending on its source. To investigate toxic effects particulate matter from different sources lung epithelial cells (A549), samples were collected residential, industrial, transportation areas in Nanjing, China. was analyzed, toxicological experiments conducted. A549 exposed using an air-liquid interface (ALI) exposure system, cytotoxic indicators detected. research results indicated that acute to at caused damage cells, induced production ROS, apoptosis, inflammatory damage, DNA with a dose-effect relationship. content heavy metals PAHs traffic source relatively high, effect traffic-source higher than industrial- residential-source samples. cytotoxicity mostly associated water-soluble ions, carbon components, metals, PAHs, endotoxin, based analysis Pearson correlation. Oxidative stress played important role PM2.5-induced biological toxicity.

Язык: Английский

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Integrin A5B1-mediated endocytosis of polystyrene nanoplastics: Implications for human lung disease and therapeutic targets

The Science of The Total Environment, Год журнала: 2024, Номер 953, С. 176017 - 176017

Опубликована: Сен. 3, 2024

Язык: Английский

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Joint effect of long-term exposure to ambient air pollution on the prevalence of chronic obstructive pulmonary disease using the Korea National Health and Nutrition Examination Survey 2010–2019

Chemosphere, Год журнала: 2024, Номер 358, С. 142137 - 142137

Опубликована: Апрель 24, 2024

Язык: Английский

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Prenatal ozone exposure and variations of the gut microbiome: Evidence from a Chinese mother-infant cohort

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 283, С. 116861 - 116861

Опубликована: Авг. 12, 2024

The gut microbiome is central to human health, but the potential impact of ozone (O

Язык: Английский

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Altered cytokine release of airway epithelial cells in vitro by combinations of Respiratory Syncytial Virus, Streptococcus pneumoniae, Printex 90 and Diesel Exhaust Particles

Environmental Research, Год журнала: 2025, Номер unknown, С. 121392 - 121392

Опубликована: Март 1, 2025

Язык: Английский

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Mechanisms of pulmonary fibrosis and lung cancer induced by chronic PM2.5 exposure: Focus on the airway epithelial barrier and epithelial-mesenchymal transition

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 297, С. 118253 - 118253

Опубликована: Май 1, 2025

Язык: Английский

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The NRF2 Response to Environmental Stress

Elsevier eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Neurobehavioral and neurochemical alterations in female mice following pregestational exposure to SARS-CoV-2 lysate protein

Neurotoxicology and Teratology, Год журнала: 2025, Номер 109, С. 107451 - 107451

Опубликована: Май 1, 2025

Язык: Английский

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Synergistic effects of air pollution and artificial light at night on diabetes risk: A prospective cohort study

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126472 - 126472

Опубликована: Май 1, 2025

Язык: Английский

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The relative contribution of PM2.5 components to the obstructive ventilatory dysfunction—insights from a large ventilatory function examination of 305,022 workers in southern China

Environment International, Год журнала: 2024, Номер 187, С. 108721 - 108721

Опубликована: Май 1, 2024

The new round of WHO/ILO Joint Estimates the Work-related Burden Disease assessment requires futher research to provide more evidence, especially on health impact ambient air pollution around workplace. However, evidence linking obstructive ventilatory dysfunction (OVD) fine particulate matter (PM2.5) and its chemical components in workers is very limited. Evidence even scarce interactive effects between occupational factors particle exposures. We aimed fill these gaps based a large function examination southern China. conducted cross-sectional study among 363,788 China 2020. annual average concentration PM2.5 were evaluated workplace through validated spatiotemporal models. used mixed-effect models evaluate risk OVD related components. Results further stratified by basic characteristics factors. Among 305,022 workers, 119,936 observed with OVD. found for each interquartile range (IQR) increase concentration, increased 27.8 (95 % confidence interval (CI): 26.5 %-29.2 %). estimates 10.9 %CI: 9.7 %-12.1 %), 15.8 14.5 %-17.2 2.6 1.4 %-3.8 17.1 15.9 %-18.4 11 9.9 %-12.2 respectively, IQR increment sulfate, nitrate, ammonium salt, organic black carbon. greater effect females, younger length service 24–45 months, professional skill workers. Furthermore, it particularly noteworthy that noise-exposed high-temperature-exposed less-dust-exposed at 5.7 %-68.2 than others. are significantly associated an OVD, stronger links certain vulnerable subgroups.

Язык: Английский

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