Interaction of GPER-1 with the endocrine signaling axis in breast cancer

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Янв. 24, 2025

G Protein-Coupled Estrogen Receptor 1 (GPER-1) is a membrane estrogen receptor that has emerged as key player in breast cancer development and progression. In addition to its direct influence on signaling, crucial interaction between GPER-1 the hypothalamic-pituitary-gonadal (HPG) axis been evidenced. The novel complex relationship HPG implies hormonal regulation with important homeostatic effects general organ reproductive tissues, but also pathophysiology of cancer, especially cancer. Recent research points great versatility GPER-1, interacting classical receptors signaling pathways related inflammation. Importantly, through activation by environmental synthetic estrogens, associated hormone therapy resistance These findings open new perspectives understanding tumor raise possibility future applications design more personalized effective therapeutic approaches.

Язык: Английский

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Unseen Toxins: Exploring the Human Health Consequences of Micro and Nanoplastics

Toxicology Reports, Год журнала: 2025, Номер 14, С. 101955 - 101955

Опубликована: Фев. 15, 2025

Язык: Английский

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Environmental Pollutants, Occupational Exposures, and Liver Disease

Seminars in Liver Disease, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Environmental pollutants significantly impact liver disease development, progression, and outcomes. This review examines the complex relationship between environmental exposures pathology, from malignant conditions like hepatocellular carcinoma to steatotic cholestatic diseases. Key factors include air pollutants, volatile organic compounds, persistent heavy metals, per- polyfluoroalkyl substances. These compounds can act through multiple mechanisms, including endocrine disruption, metabolic perturbation, oxidative stress, direct hepatotoxicity. The of these is often modified by such as sex, diet, genetic predisposition. Recent research has revealed that even low-level certain chemicals affect health, particularly when combined with other risk factors. emergence exposomics a tool promises enhance our understanding how influence disease. Importantly, exposure effects vary demographic socioeconomic factors, highlighting justice concerns. Implementation this knowledge in clinical practice requires new diagnostic approaches, healthcare system adaptations, increased awareness among medical professionals. In conclusion, provides comprehensive examination current evidence linking discusses implications for public health policy.

Язык: Английский

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Hydro-geochemical investigation and Fluoride levels in Lakes: A comprehensive health risk assessment

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

The proposed study investigates the key hydro-geochemical relationships between salts and ions, their spatial distribution, sources of occurrence, non-malignant health effects associated with fluoride contamination risk in lakes Rajasthan, India. covers a cluster 18 lakes, assessed using standard procedures from USEPA WHO. findings highlight significant influence both anthropogenic activities natural lithology on which are crucial potable domestic water supply. Water quality parameters such as BOD, pH, Fe, Mn²⁺, PO₄³⁻, F⁻, HCO₃⁻ exceeded permissible limits set by Correlation analysis revealed strong positive associations (F⁻) like Ca²⁺, electrical conductivity (EC), K⁺, HCO₃⁻, influenced geological factors, soil composition, pH levels, temperature, ion presence, redox reactions. Hydro-geochemical characteristics were primarily represented combinations Ca-HCO₃, Mg-HCO₃, SO₄-HCO₃, Na-K-HCO₃, reflecting context, high bicarbonate elevated levels Mg²⁺ sulphate ions. hazard quotient index (HQI) for exposure to risks, an HQI greater than 1 infants (93%), followed children (89%), teenagers (79%), adults (54%). area, including regions Udaipur, Jodhpur, Alwar, Ajmer, showed that approximately 52% population falls within Category F2 (concentrations 0.5 mg/L 1.5 mg/L).

Язык: Английский

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Gestational and lactational exposure to DEHP triggers ACSL4/TFR-mediated hippocampal neuronal ferroptosis via YAP activation: implication for the neurocognitive disorders in male offspring

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138081 - 138081

Опубликована: Март 1, 2025

Язык: Английский

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