Prenatal exposure to polycyclic aromatic hydrocarbons and blood pressure in the early life of children

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117830 - 117830

Опубликована: Фев. 1, 2025

Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with many adverse health outcomes. This cohort study investigates the association between prenatal exposure PAHs and blood pressure in children aged 4-6 years. Conducted Shenyang, China, includes 5642 whose mothers provided urine samples third trimester, which were analyzed for PAH metabolites. Children's indicators, including systolic (SBP), diastolic (DBP), mean arterial (MAP), pulse (PP), measured during follow-up. Multivariable regression models, adjusted key confounders, used explore associations metabolites pressure. Additionally, we applied quantile g-computation (g-comp) Bayesian kernel machine (BKMR) assess combined interaction effects of multiple Prenatal specific showed significant parameters. 2-hydroxynaphthalene, 3-hydroxyfluorene, 9-hydroxyphenanthrene, 1-hydroxypyrene positively linked SBP. For DBP, 1-hydroxynaphthalene, total revealed strong associations. PP was significantly 3-Hydroxyfluorene, while MAP consistent 1-hydroxypyrene. G-comp analysis increases SBP, MAP, no effect on PP. BKMR evidence SBP or DBP but suggested potential positive at higher quantiles, indicating nuanced, exposure-dependent relationships study, being one first these children, provides important insights into long-term impacts childhood cardiovascular health.

Язык: Английский

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Single and joint associations of exposure to polycyclic aromatic hydrocarbons with hypertensive disorders of pregnancy: a nested case-control study

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126275 - 126275

Опубликована: Май 1, 2025

Язык: Английский

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Identification of the associations between co-exposure to organophosphate flame retardants and thyroid dysfunction and exposure risk factors in residents of Shanghai, China

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 125911 - 125911

Опубликована: Фев. 1, 2025

Язык: Английский

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Time-Varying Relationship between Maternal Trace Element Exposure and Gestational Hypothyroidism

Environmental Science & Technology Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Язык: Английский

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Sucralose Promotes Benzo(a)Pyrene-Induced Renal Toxicity in Mice by Regulating P-glycoprotein

Antioxidants, Год журнала: 2025, Номер 14(4), С. 474 - 474

Опубликована: Апрель 16, 2025

Background: Sucralose and benzo(a)pyrene (B[a]P) are widespread foodborne substances known to harm human health. However, the effects of their combined exposure on kidney function remain unclear. This study aimed investigate mechanisms by which sucralose B[a]P induce injury through P-glycoprotein (PGP/ABCB1), a crucial protein involved in cellular detoxification. Methods: C57BL/6N mice were co-treated with for 90 days evaluate impact histopathology function. In vitro experiments assessed cell viability, reactive oxygen species (ROS) levels, accumulation flow cytometry. Molecular docking thermal shift assay (CETSA) used determine binding affinity PGP. Furthermore, PCR, Western blotting, immunohistochemistry performed analyze expression PGP its upstream transcription factors. Results: Ninety co-exposure significantly exacerbated renal dysfunction mice, as evidenced elevated level serum creatinine urea nitrogen, could be reverted ROS scavenger N-acetyl cysteine (NAC). vitro, promoted B[a]P, consequently enhancing B[a]P-induced growth inhibition production. Consistently, was enhanced knockdown both HK2 HEK-293 cells. Mechanistically, can directly bind PGP, competitively inhibiting efflux capacity increasing intracellular retention. Prolonged further downregulated expression, possibly reductions transcriptional regulators (PXR, NRF2, NF-κB). Conclusions: Co-exposure exacerbates impairing inhibits activity, resulting within triggers oxidative stress growth, demonstrates that potentiates nephrotoxicity PGP-mediated detoxification pathways, thus underscoring critical need toxicity risks associated these compounds.

Язык: Английский

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Evaluation of PM2.5 bound microplastics and plastic additives in several cities in Taiwan: Spatial distribution and human health risk

The Science of The Total Environment, Год журнала: 2024, Номер 959, С. 178213 - 178213

Опубликована: Дек. 28, 2024

Язык: Английский

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Effect of combined exposure to phthalates and polycyclic aromatic hydrocarbons during early pregnancy on gestational age and neonatal size: A prospective cohort study

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 116868 - 116868

Опубликована: Авг. 14, 2024

Many studies have indicated that individual exposure to phthalates (PAEs) or polycyclic aromatic hydrocarbons (PAHs) affects pregnancy outcomes. However, combined PAEs and PAHs presents a more realistic situation, research on the effects of gestational age newborn size is still limited. This study aimed assess neonatal birth size. Levels 9 PAE 10 PAH metabolites were measured from urine samples 1030 women during early Zunyi Birth Cohort in China. Various statistical models, including linear regression, restricted cubic spline, Bayesian kernel machine quantile g-computation, used effects, dose-response relationships, respectively. The results this prospective revealed each ten-fold increase concentration monoethyl phthalate (MEP), 2-hydroxynaphthalene (2-OHNap), 2-hydroxyphenanthrene (2-OHPhe), 1-hydroxypyrene (1-OHPyr) decreased by 1.033 days (95 % CI: -1.748, -0.319), 0.647 -1.076, -0.219), 0.845 -1.430, -0.260), 0.888 -1.398, -0.378), Moreover, when concentrations MEP, 2-OHNap, 2-OHPhe, 1-OHPyr exceeded 0.528, 0.039, 0.012, 0.002 µg/g Cr, respectively, manner. Upon analyzing selected as mixture, we found they significantly negatively associated with age, weight, ponderal index, being most important contributor. These findings highlight adverse single age. Therefore, future longitudinal cohort larger sample sizes should be conducted across different geographic regions ethnic groups confirm impact

Язык: Английский

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Evaluation of Pm2.5 Bound Microplastics and Plastic Additives in Several Cities in Taiwan: Spatial Distribution and Human Health Risk

Опубликована: Янв. 1, 2024

Язык: Английский

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