Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 10, 2024
Type
2
diabetes
mellitus
(T2DM)
is
a
chronic
metabolic
disease
caused
by
insulin
resistance
(IR)
and
insufficient
secretion.
Its
characteristic
pathophysiological
processes
involve
the
interaction
of
multiple
mechanisms.
In
recent
years,
globally,
prevalence
T2DM
has
shown
sharp
rise
due
to
profound
changes
in
socio-economic
structure,
persistent
influence
environmental
factors,
complex
role
genetic
background.
It
worth
noting
that
most
patients
show
significant
IR,
which
further
exacerbates
difficulty
progression
prevention.
process
extensively
exploring
pathogenesis
T2DM,
dynamic
equilibrium
gut
microbes
its
diverse
activities
have
increasingly
emphasized
central
T2DM.
Bile
acids
(BAs)
metabolism,
as
crucial
link
between
development
not
only
precisely
regulates
lipid
absorption
metabolism
but
also
profoundly
influences
glucose
homeostasis
energy
balance
through
intricate
signaling
pathways,
thus
playing
pivotal
IR
This
review
aims
delve
into
specific
mechanism
BAs
contribute
especially
emphasizing
how
mediate
transformation
based
on
current
traditional
Chinese
medicine
research.
Ultimately,
it
seeks
offer
new
insights
prevention
treatment
Diet,
genetics,
environment
intricately
sculpt
microbiota
influencing
T2DM-IR.
The
research
illuminated
impact
single
herbal
medicine,
TCM
formulae,
external
therapeutic
methods
such
electroacupuncture
pool
perturbations
structure.
affects
well
sensitivity.
Additionally,
pathways
including
BA-FXR-SHP,
BA-FXR-FGFR15/19,
BA-FXR-NLRP3,
BA-TGR5-GLP-1,
BAs-TGR5/FXR
been
identified
significantly
alter
blood
levels
improve
IR.
These
findings
novel
approaches
for
enhancing
managing
disorders
among
with
Genes,
Год журнала:
2024,
Номер
15(6), С. 729 - 729
Опубликована: Июнь 2, 2024
Background:
Unbalances
in
the
gut
microbiota
have
been
proposed
as
a
possible
cause
of
esophageal
cancer
(ESCA),
yet
exact
causal
relationship
remains
unclear.
Purpose:
To
investigate
potential
between
and
ESCA
with
Mendelian
randomization
(MR)
analysis.
Methods:
Genome-wide
association
studies
(GWASs)
207
microbial
taxa
(5
phyla,
10
classes,
13
orders,
26
families,
48
genera,
105
species)
205
metabolic
pathways
conducted
by
Dutch
Microbiome
Project
(DMP)
FinnGen
cohort
GWAS
specified
summary
statistics.
possibility
mediation
effect
ESCA,
MR
analyses
were
performed
for
1091
blood
metabolites
309
metabolite
ratios.
Results:
analysis
indicated
that
relative
abundance
was
associated
but
all
12
no
statistically
significant
existing.
Two
ratio
discovered
to
be
mediating
factors
pathway
from
ESCA.
Conclusion:
This
research
effects
offered
genetic
evidence
favor
correlation
Heliyon,
Год журнала:
2024,
Номер
10(17), С. e36894 - e36894
Опубликована: Авг. 24, 2024
Epidemiological
studies
linking
metabolic
syndrome
(MetS)
and
exposure
to
perfluoroalkyl
substances
(PFASs)
are
limited,
the
observations
gleaned
thus
far
inconclusive.
The
study
was
performed
explore
association
of
serum
PFASs
both
singly
in
a
mixed
manner
with
MetS,
meanwhile
examine
whether
this
mediated
by
albumin
US
national
population.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 10, 2024
Type
2
diabetes
mellitus
(T2DM)
is
a
chronic
metabolic
disease
caused
by
insulin
resistance
(IR)
and
insufficient
secretion.
Its
characteristic
pathophysiological
processes
involve
the
interaction
of
multiple
mechanisms.
In
recent
years,
globally,
prevalence
T2DM
has
shown
sharp
rise
due
to
profound
changes
in
socio-economic
structure,
persistent
influence
environmental
factors,
complex
role
genetic
background.
It
worth
noting
that
most
patients
show
significant
IR,
which
further
exacerbates
difficulty
progression
prevention.
process
extensively
exploring
pathogenesis
T2DM,
dynamic
equilibrium
gut
microbes
its
diverse
activities
have
increasingly
emphasized
central
T2DM.
Bile
acids
(BAs)
metabolism,
as
crucial
link
between
development
not
only
precisely
regulates
lipid
absorption
metabolism
but
also
profoundly
influences
glucose
homeostasis
energy
balance
through
intricate
signaling
pathways,
thus
playing
pivotal
IR
This
review
aims
delve
into
specific
mechanism
BAs
contribute
especially
emphasizing
how
mediate
transformation
based
on
current
traditional
Chinese
medicine
research.
Ultimately,
it
seeks
offer
new
insights
prevention
treatment
Diet,
genetics,
environment
intricately
sculpt
microbiota
influencing
T2DM-IR.
The
research
illuminated
impact
single
herbal
medicine,
TCM
formulae,
external
therapeutic
methods
such
electroacupuncture
pool
perturbations
structure.
affects
well
sensitivity.
Additionally,
pathways
including
BA-FXR-SHP,
BA-FXR-FGFR15/19,
BA-FXR-NLRP3,
BA-TGR5-GLP-1,
BAs-TGR5/FXR
been
identified
significantly
alter
blood
levels
improve
IR.
These
findings
novel
approaches
for
enhancing
managing
disorders
among
with
