Polystyrene nanoplastics amplify the toxic effects of PFOA on the Chinese mitten crab (Eriocheir sinensis)

Journal of Hazardous Materials, Год журнала: 2025, Номер 488, С. 137488 - 137488

Опубликована: Фев. 4, 2025

Язык: Английский

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Comparative toxicity assessment of alternative versus legacy PFAS: Implications for two primary trophic levels in freshwater ecosystems

Journal of Hazardous Materials, Год журнала: 2024, Номер 477, С. 135269 - 135269

Опубликована: Июль 20, 2024

Язык: Английский

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PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics

Seminars in Reproductive Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Abstract Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants found in human tissues persist the environment, posing significant risks to reproductive health. This review examines impact of PFAS exposure on male health, with a focus sperm epigenetics. PFASs disrupt endocrine function by altering key hormones impairing motility, quality, viability. Epidemiologic animal studies highlight inconsistent yet concerning associations between semen parameters, as well altered gene expression DNA methylation patterns. Moreover, during critical windows development has been linked differential impacts versus female pubertal development, cognitive outcomes, physiology, emphasizing complexity interactions. comprehensive analysis highlights need for continued research into mechanisms which influence health potential implications The emphasizes importance understanding epigenetic behind these disruptions, particularly its role heritable changes. Investigating modifications driven is crucial elucidating chemicals Future should changes both immediate fertility outcomes transgenerational risks.

Язык: Английский

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The Toxicological Effects of Perfluorooctanoic Acid (Pfoa) Exposure in Large Yellow Croaker (Larimichthys Crocea): Linking Liver Damage to Gut Microbiota Dysbiosis

Опубликована: Янв. 1, 2025

Язык: Английский

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The toxicological effects of perfluorooctanoic acid (PFOA) exposure in large yellow croaker (Larimichthys crocea): exploring the relationship between liver damage and gut microbiota dysbiosis

Environmental Research, Год журнала: 2025, Номер 278, С. 121683 - 121683

Опубликована: Апрель 23, 2025

Язык: Английский

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Insights into PFAS contaminants before and after sewage discharges into a marine protected harbour

Chemosphere, Год журнала: 2024, Номер 366, С. 143526 - 143526

Опубликована: Окт. 1, 2024

Per and polyfluoroalkyl substances (PFAS) their degradation products are a concern to human ecosystem health. Wastewater treatment plants not efficient at removing PFAS compounds thought be major source of these marine environments. The sewerage infrastructure in the UK, has over 20,000 combined stormwater overflows (CSOs). These CSOs relief values whereby untreated wastewater can discharge under permit from Environment Agency with exceptional rain/snowfall conditions. discharged 3.6 million monitored hours into English rivers coasts 2023. Concerns have been raised about proximity CSO discharges highly protected habitats. This study is first determine that concentrations elevated bay (Langstone Harbour, England) following recent sewage releases compared an extended period without discharge. Analysis was carried out suite 54 which only one (PFHpA) detectable above LOD prior but 8 afterwards. included banned PFOS (Linear Branched 8.6 ng/L ∓ 0.90) PFOA (2.9 0.29) were annual average EQS for inland 'other' surface waters. Most detected doubled concentration LODs. two-fold increases we discuss likely conservative estimates based on use LODs tidal Additional Oysters (Crassostrea gigas) Seaweed (Fucus vesiculosus) taken revealing high shorter chain PFBA (6.99μg/kg 2.42 ww) seaweed samples. seaweeds calculated bioaccumulation factors (BAF) > 6000 indicating algae might important reservoir some contamination. We results context largescale nationally globally, call upon need better understanding transfer contaminants food chains.

Язык: Английский

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Fluorene-9-bisphenol impaired male fertility through disrupting the testicular function and local microenvironment

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 116880 - 116880

Опубликована: Авг. 13, 2024

Past studies have observed that BHPF induces multi-organ toxicity, however, whether it damage to male reproductive system and the specific mechanism remains unclear. In present study, mice were given 0, 2, 10 or 50 mg/kg/day of by gavage for 35 days observe its effect on organ sperm quality. The results indicated decreased count motility in a dose-dependent manner. Besides, our demonstrated triggered proliferation inhibition cell death germ cells vivo vitro. Also, reduced expression function markers cells, Sertoli Leydig indicating testis cells. Simultaneously, testicular microenvironment was found be altered BHPF, as presented with declined testosterone level local regulators. Overall, findings detrimental effects mice, suggesting disturbance underlying damage.

Язык: Английский

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Hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts sex differentiation of zebrafish (Danio rerio) via an epigenetic mechanism of DNA methylation

Aquatic Toxicology, Год журнала: 2024, Номер 275, С. 107077 - 107077

Опубликована: Сен. 5, 2024

Язык: Английский

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Reproductive toxicity and gene expression alterations in aquatic environments: Expanding the insights of the recent guppy study on PFAS exposure

Environment International, Год журнала: 2024, Номер 190, С. 108923 - 108923

Опубликована: Авг. 1, 2024

Язык: Английский

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Possible mechanisms for adverse effects on zebrafish sperm and testes associated with low-level chronic PFOA exposure

Aquatic Toxicology, Год журнала: 2024, Номер 276, С. 107108 - 107108

Опубликована: Сен. 26, 2024

Язык: Английский

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