Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities

Science Advances, Год журнала: 2025, Номер 11(4)

Опубликована: Янв. 22, 2025

Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting regular physiological processes organs. Nanoscale plastics can breach blood-brain barrier, leading to neurotoxic effects. How cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques investigate within vivo. We show that circulating are phagocytosed lead these cells obstruction capillaries cortex. These blockages as thrombus formation reduced blood flow neurological abnormalities mice. Our data reveal a mechanism which disrupt tissue function indirectly through regulation cell interference with local circulation, rather than direct penetration. revelation offers lens comprehend toxicological implications invade bloodstream.

Язык: Английский

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Polyvinyl chloride (PVC), its additives, microplastic and human health: Unresolved and emerging issues

The Science of The Total Environment, Год журнала: 2025, Номер 960, С. 178276 - 178276

Опубликована: Янв. 1, 2025

Язык: Английский

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Predicting microplastic quantities in Indonesian provincial rivers using machine learning models

The Science of The Total Environment, Год журнала: 2025, Номер 961, С. 178411 - 178411

Опубликована: Янв. 1, 2025

Язык: Английский

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Improved multivariate quantification of plastic particles in human blood using non-targeted pyrolysis GC-MS

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137584 - 137584

Опубликована: Фев. 11, 2025

Accurate analytical methods are crucial to assess human exposure micro- and nanoplastics (MNPs). Quantitative pyrolysis-gas chromatography coupled with mass spectrometry (Py-GC-MS) has recently been used for quantifying MNPs in blood. However, pyrolysis introduces complex effects such as secondary reactions between matrix compounds polymers. This work a non-targeted multivariate approach improve the identification quantification of polyethylene (PE), poly(vinyl chloride) (PVC) terephthalate (PET). After spiking extracted blood samples, PARADISe was componentization integration 417 features detected Py-GC-MS. Quantification based on calibration models demonstrated superior performance when compared univariate regression. Feature selection approaches were identify optimal feature subsets, which reduced errors by 30 % PE, 10 PVC 38 PET. In addition, chemical insight into processes obtained studying (MEs) The PE appeared be minimally affected (MEs = 81-154 %), while PET exhibited interactions 40-9031 impacting its accuracy. conclusion, this research highlights importance accounting during more accurate robust

Язык: Английский

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Exposure to polyethylene and polyvinylchloride microplastics caused advanced puberty onset in females through promoting hypothalamic GnRH expression

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117906 - 117906

Опубликована: Фев. 1, 2025

Precocious puberty (PP) is a common pediatric endocrine disorder that affects children's growth and sexual development. Environmental pollutants, especially microplastics (MPs), may be an important triggering factors in PP. MPs were widely found living environment, while the impact of on pubertal development remains unknown. In this study, 14 serum samples collected from central precocious (CPP) girls healthy controls. The concentration total CPP (68.19 ± 26.49 mg/kg) showed significant increase than controls (36.94 13.22 mg/kg). 5 11 types detected, among which PE (CPP, 28.22 %; Control, 31.62 %) PVC 62.67 58.14 being dominant ones. Correlation analysis between sex hormone revealed negatively correlated with progesterone positively dehydroepiandrosterone (DHEAS). order to investigate toxic effects onset, young female mice at 21 days orally administered various concentrations for two weeks. Female exposed (PE, 3 mg/day; PVC, 6 mg/day) had advanced vaginal opening, none changes body weight. Immunohistochemical staining demonstrated exposure during could activate microglia, astrocytes promote GnRH expression hypothalamus, leading earlier onset. These data suggested can absorbed accumulated brain gonad after gavage, accelerate initiation. This study provided valuable evidence threatened normal progression

Язык: Английский

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Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics

Environment International, Год журнала: 2024, Номер 192, С. 109012 - 109012

Опубликована: Сен. 17, 2024

Язык: Английский

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Isolation and characterization of microplastics from the human respiratory system: sputum, broncho-alveolar lavage fluid, and pleural fluid simultaneously

Environmental Pollution, Год журнала: 2024, Номер unknown, С. 125389 - 125389

Опубликована: Ноя. 1, 2024

Язык: Английский

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Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip

ACS Nano, Год журнала: 2024, Номер 18(45), С. 31569 - 31585

Опубликована: Ноя. 1, 2024

Exposure to micro- and nanoplastics (MNPs) has been implicated in potential cardiotoxicity. However, vitro models based on cardiomyocyte cell lines lack crucial cardiac characteristics, while interspecies differences animal compromise the reliability of conclusions. In addition, current research predominantly focused single-time point exposures MNPs, neglecting comparative analyses injury across early late stages. Moreover, there remains a large gap understanding susceptibility MNPs under pathological conditions. To address these limitations, this study integrated organoids (COs) organ-on-a-chip (OoC) technology develop organoid-on-a-chip (COoC), which was validated for cardiotoxicity evaluation through multiple dimensions. Based COoC, we conducted dynamic observation damage caused by short- long-term exposure polystyrene (PS-NPs). Oxidative stress, inflammation, disruption calcium ion homeostasis, mitochondrial dysfunction were confirmed as mechanisms PS-NP-induced events stages, fibrosis emerged prominent feature Notably, low-dose exacerbated myocardial infarction symptoms states, despite no significant shown healthy models. conclusion, findings further deepened our cardiotoxic effects introduced promising platform assessing

Язык: Английский

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Effect of polypropylene microplastics on the performance of membrane bioreactors in wastewater treatment

Environmental Research, Год журнала: 2025, Номер unknown, С. 120837 - 120837

Опубликована: Янв. 1, 2025

Язык: Английский

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Assessing the Efficacy of Pyrolysis–Gas Chromatography–Mass Spectrometry for Nanoplastic and Microplastic Analysis in Human Blood

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Humans are constantly exposed to micro- and nanosized plastics (MNPs); however, there is still limited understanding of their fate within the body, partially due limitations with current analytical techniques. The study assessed appropriateness pyrolysis–gas chromatography–mass spectrometry (Py-GC-MS) analysis for quantification a range polymers in human blood. An extraction protocol that reduced matrix interferences (false positives) polyethylene (PE) polyvinyl chloride (PVC) was developed validated. Extraction recoveries ranged 7–109%, although surface-modified polystyrene (carboxylated) increased nanoparticle from 17 52%. Realistic detection limits were calculated each polymer, accounting suppression recovery. These up 20 times higher than nominal Milli-Q water. Finally, method tested pilot Australian population. PE but present, no other above limits. It concluded Py-GC-MS currently not suitable PVC biological matrices presence nonspecific pyrolysis products. Furthermore, while it plausible detect some blood, estimated exposure concentrations needed approaching technique.

Язык: Английский

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