Pollutants in Microenvironmental Cellular Interactions During Liver Inflammation Cancer Transition and the Application of Multi-Omics Analysis

Toxics, Год журнала: 2025, Номер 13(3), С. 163 - 163

Опубликована: Фев. 25, 2025

This study categorizes pollutant-induced inflammation–cancer transition into three stages: non-alcoholic fatty liver disease (NAFLD), fibrosis, and hepatocellular carcinoma (HCC). It systematically reveals the temporal heterogeneity of damage. The findings indicate that pollutants not only directly damage hepatocytes but also modulate key cells in immune microenvironment, such as hepatic stellate (HSCs) Kupffer cells, thereby amplifying inflammatory fibrotic responses, ultimately accelerating progression HCC. Mechanistically, early stage primarily cause hepatocyte injury through oxidative stress lipid metabolism dysregulation. During fibrosis stage, promote by inducing extracellular matrix accumulation, while HCC they drive tumorigenesis via activation Wnt/β-catenin pathway p53 inactivation. Through multi-omics analyses, this identifies critical pathogenic molecules signaling pathways regulated pollutants, providing new insights their mechanisms, potential biomarkers, therapeutic targets. These offer valuable guidance for development diagnostic strategies diseases formulation environmental health risk prevention measures.

Язык: Английский

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Chemical risk assessment in food animals via physiologically based pharmacokinetic modeling – Part II: Environmental pollutants on animal and human health assessments

Environment International, Год журнала: 2025, Номер unknown, С. 109372 - 109372

Опубликована: Март 1, 2025

Human activities generate a large amount of environmental pollutants, including drugs and agricultural industrial chemicals that are released into the air, water, soil. Environmental pollutants can enter food animals through contaminated feed posing risks to human health via chain. Physiologically based pharmacokinetic (PBPK) modeling is used predict target organ dosimetry informing risk assessment. However, there lack critical reviews concerning PBPK models for in last several years (2020-2024). This review part series focusing on applications inform safety assessments. Part I focused veterinary drugs. The present article II focuses chemicals, pesticides, polychlorinated biphenyls (PCBs), bisphenols, per- polyfluoroalkyl substances (PFAS). discusses existing challenges developing shares our perspectives future directions, combinations vitro vivo extrapolation (IVIVE), machine learning artificial intelligence, read-across approaches, quantitative pharmacodynamic enhance potential assessing safety.

Язык: Английский

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Assessment of per- and polyfluoroalkyl substances (PFAS) exposure and associations with oxidative stress biomarkers among pregnant women from the PROTECT cohort

The Science of The Total Environment, Год журнала: 2025, Номер 973, С. 179130 - 179130

Опубликована: Март 20, 2025

Язык: Английский

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Perfluorooctane sulfonic acid: a possible risk factor of endothelial dysfunction based on in silico and in vitro studies

Archives of Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Язык: Английский

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PFAS: The Journey from Wonder Chemicals to Environmental Nightmares and the Search for Solutions

Applied Sciences, Год журнала: 2024, Номер 14(19), С. 8611 - 8611

Опубликована: Сен. 24, 2024

Per- and polyfluoroalkyl substances (PFAS) are diverse synthetic chemicals manufactured over seven decades. It is an aliphatic molecule with a basic hydrophobic structure of carbon fluorine linked to hydrophilic end group. Due their physicochemical properties associated the unique structure, PFAS has been used in wide variety applications including aqueous film-forming foams (AFFF), paper, carpets, non-stick cookware, etc. as they make products resistant water, heat, stains. These molecules have drawn great attention recently for properties, high stability low degradability, so-called “Forever Chemicals”. strongest carbon-fluorine bond which makes them persistent environment. Hence it contaminates natural resources endangers public health. This review discusses discovery, development, evolution from wonder chemical era nightmare era, exposure its impacts on human health environment, current remediation techniques, future trends related products. The primary objective this identify knowledge gaps contamination, methods, possible alternatives.

Язык: Английский

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Metabolic changes associated with PFAS exposure in firefighters: A pilot study

The Science of The Total Environment, Год журнала: 2024, Номер 953, С. 176004 - 176004

Опубликована: Сен. 10, 2024

Язык: Английский

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Effects of Mixed Exposure to PFAS on Adolescent non-alcoholic fatty liver disease: Integrating Evidence from Human Cohorts, Toxicogenomics, and Animal Models to Uncover Mechanisms and Potential Target Sites

Journal of Hazardous Materials, Год журнала: 2024, Номер 485, С. 136854 - 136854

Опубликована: Дек. 13, 2024

Язык: Английский

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Potential of Photocatalytic Nanomaterials for PFOA and PFOS degradation: Challenges and Opportunities

Journal of environmental chemical engineering, Год журнала: 2024, Номер unknown, С. 115201 - 115201

Опубликована: Дек. 1, 2024

Язык: Английский

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