Cited by Comprehensive utilization of in silico approach and in vitro experiment to unveil the molecular mechanisms of mono (2-ethylhexyl) phthalate-induced lung adenocarcinoma

Subacute dibutyl phthalate exposure impairs hepatic T cells and facilitates hepatitis B progression in mouse liver DOI

Zhenru Zhu,

Dongli Linghu,

Yongyi Luo

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 299, С. 118398 - 118398

Опубликована: Май 28, 2025

Язык: Английский

Процитировано

Per- and Polyfluoroalkyl Substances Suppress Macrophage Alternative Activation to Disrupt Hepatic Lipid Metabolism DOI

Lijuan You,

Xiaohong Wang,

Yuan Zhi

и другие.

Chemical Research in Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Per- and polyfluoroalkyl substances (PFAS) are pervasive environmental pollutants with diverse toxic effects (e.g., hepatotoxicity metabolism disorder). Macrophages played a key role in metabolic response; however, the effect of macrophage on PFAS-induced toxicity underlying mechanisms remain poorly understood. In this study, we constructed high-content cell model by utilizing activation differentiation human THP-1 monocytes into alternative macrophages, enabling rapid quantitative screening numerous PFAS. We applied to screen 10 PFASs identified that PFOA PFUnDA significantly suppressed macrophages disrupting PPAR signaling pathway. Oral exposure WT mice also impaired liver induced hepatocyte hypertrophy, dysfunction, systemic lipid disorders. Moreover, macrophage-specific knockout PPARγ exacerbated PFUnDA-induced suppression subsequent hepatotoxicity. Activation balance between PPARα may be critical factor affect macrophage. These findings highlight immunometabolism regulatory humans.

Язык: Английский

Процитировано

Myricetin alleviates the mechanism of IL-1β production caused by the endocrine-disrupting chemical Di(2-ethylhexyl) phthalate in RAW 264.7 cells DOI

Jiyeon Park, Sei‐Jung Lee

Tissue and Cell, Год журнала: 2024, Номер 93, С. 102683 - 102683

Опубликована: Дек. 13, 2024

Язык: Английский

Процитировано

Comprehensive utilization of in silico approach and in vitro experiment to unveil the molecular mechanisms of mono (2-ethylhexyl) phthalate-induced lung adenocarcinoma DOI

Wenwen Wang, Junying Li,

Xingwang Qie

и другие.

Bioorganic Chemistry, Год журнала: 2024, Номер 153, С. 107947 - 107947

Опубликована: Ноя. 6, 2024

Язык: Английский

Процитировано