Mass Spectrometry Imaging Unveils the Metabolic Effect of 6PPD-Quinone in Exposed Mice
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine
quinone
(6PPD-Q)
has
gained
widespread
attention
as
an
emerging
significant
environmental
contaminant,
but
its
biochemical
toxicity
in
mammals
remains
inadequately
explored.
In
this
study,
the
systemic
toxicological
effects
of
6PPD-Q
mouse
models
exposed
to
both
high
and
low
doses
were
investigated.
Matrix-assisted
laser
desorption/ionization
mass
spectrometry
imaging
(MALDI
MSI)
was
applied
evaluate
on
major
organs,
including
liver,
kidneys,
spleen,
testes.
Notably,
caused
similar
multiorgan
metabolic
disturbances,
with
changes
antioxidant
levels,
highlighting
oxidative
stress
a
key
factor
6PPD-Q-induced
damage.
Further
results
revealed
that
disrupts
critical
pathways,
glutathione
metabolism,
ascorbic
acid
energy
amino
which
are
associated
stress,
immune
dysfunction,
disruptions
kidney
testis.
This
study
provides
important
insights
into
mechanisms
underscores
need
for
further
research
assess
potential
health
risks,
could
guide
future
policies
human
risk
assessments.
Язык: Английский
Protective Role of Physical Activity and Antioxidant Systems During Spermatogenesis
Biomolecules,
Год журнала:
2025,
Номер
15(4), С. 478 - 478
Опубликована: Март 25, 2025
Oxidative
stress
is
a
significant
factor
that
contributes
to
male
infertility
and
sperm
dysfunction.
In
this
condition,
an
increase
in
ROS
production
exceeds
the
body’s
antioxidant
defenses,
resulting
decline
spermatozoa
quality
fertilizing
capacity.
Furthermore,
excessive
has
been
linked
promotion
of
genomic
damage,
lipid
peroxidation,
inflammation,
altered
enzyme
activity,
ultimately,
irreversible
alterations,
cell
death,
seminal
parameters
associated
with
infertility.
It
established
physical
activity
(PA),
acting
on
inflammatory
improving
defense,
can
alleviate
negative
effects
caused
by
free
radicals,
offering
numerous
health
benefits
positively
influencing
quality.
The
objective
review
highlight
mechanisms
production,
physiological
pathophysiological
roles
relation
reproductive
system,
recent
knowledge
impact
some
protocols
PA
these
systems
molecular
involved.
Язык: Английский
Editorial: Environmental threats to human reproduction
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 2, 2024
These
environmental
stressors
acts
via
multiple
pathways.
First,
they
disrupt
the
endocrine
system
by
mimicking
or
blocking
sex
hormones
(Akhigbe
et
al.,
2022).
They
may
also
induce
oxidative
stress
upregulating
generation
of
free
radicals
and
suppressing
antioxidants
(Kumar
2018;Akhigbe
2021),
trigger
inflammation
immune
response
(Li
2021;Ashonibare
2024b),
promote
genotoxicity
(Choudhuri
2021)
Although
SARS-CoV-2
remains
quite
novel,
convincing
evidences
have
been
provided
on
its
possible
link
with
infertility
Hamed,
2020;Adeyemi
2022)
Язык: Английский