Metagenomics unveils the role of hospitals and wastewater treatment plants on the environmental burden of antibiotic resistance genes and opportunistic pathogens

The Science of The Total Environment, Год журнала: 2025, Номер 961, С. 178403 - 178403

Опубликована: Янв. 1, 2025

Antimicrobial resistance (AMR) is a global health challenge, with hospitals and wastewater treatment plants (WWTPs) serving as significant pathways for the dissemination of antibiotic genes (ARGs). This study investigates potential wastewater-based epidemiology (WBE) an early warning system assessing burden AMR at population level. In this comprehensive year-long study, effluent was collected weekly from three large hospitals, treated untreated were monthly associated community WWTPs. Metagenomic analysis revealed significantly higher relative abundance diversity ARGs in hospital than Notably, conferring to clinically antibiotics such β-lactams, aminoglycosides, sulfonamides, tetracyclines more prevalent effluents. Conversely, rifampicin MLS (macrolides-lincosamide-streptogramin) commonly detected WWTPs, particularly effluent. Network identified bacterial hosts, which are key carriers these ARGs. The further highlighted variability ARG removal efficiencies across none achieving complete elimination or reduction diversity. Additionally, profiles remained relatively consistent throughout indicating persistent release baseload pathogenic bacteria into surface waters, potentially polluting aquatic environments entering food chain. underscores need routine WBE surveillance, enhanced strategies, hospital-level source control measures mitigate environment.

Язык: Английский

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Selecting suitable sites for livestock manure composting via the integration of machine learning, median center and geographic information system

Agricultural Systems, Год журнала: 2025, Номер 226, С. 104300 - 104300

Опубликована: Март 14, 2025

Язык: Английский

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The optimization of the multi-component organic wastes in mixed aerobic composting ratio based on antibiotic resistance gene reduction

Environmental Technology & Innovation, Год журнала: 2025, Номер unknown, С. 104160 - 104160

Опубликована: Март 1, 2025

Язык: Английский

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Wastewater-based AMR surveillance associated with tourism on a Caribbean island (Guadeloupe)

Journal of Global Antimicrobial Resistance, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Gut bacteriome dynamics in high altitude-adapted chicken lines: a key to future poultry therapeutics

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 7, 2025

Abstract High-altitude-adapted chickens harbor a unique gut bacteriome essential for their survival under extremely cold and hypoxic environment, however, little is known about population functional dynamics, limiting application in poultry production. Hence, this study employed amplicon-based metagenomics to examine the bacterial diversity profile two high-altitude-adapted chicken lines, e.g. LEHBRO-1 LEHBRO-3. The results revealed significant variations taxonomic abundance at phylum level, with Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria predominating LEHBRO-1, whereas Planctomycetes, predominated Genus-level Linear Discriminant Analysis Effect Size (LEfSe) biomarker analysis also substantiated differences communities between lines. Furthermore, profiling enrichment of carbohydrate, nucleotide, lipid, amino acid, fatty energy, glycan metabolic pathways bacteriomes these high-altitude Statistical Metagenomic Profiles (STAMP) identified difference purine protein metabolism These findings indicate chickens, which would provide foundation future research on therapeutics improve health productivity areas.

Язык: Английский

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Vermicomposting significantly reduced antibiotic resistance genes in cow manure even under high tetracycline concentrations

Bioresource Technology, Год журнала: 2024, Номер unknown, С. 132002 - 132002

Опубликована: Дек. 1, 2024

Язык: Английский

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Bioconversion of sulfamethazine-contaminated chicken manure by black soldier fly larvae: Effects on antibiotic resistance genes and microbial communities

Journal of Environmental Management, Год журнала: 2024, Номер 371, С. 123206 - 123206

Опубликована: Ноя. 3, 2024

Язык: Английский

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