Cross-taxa Extrapolation: Is There a Role for Thyroid Hormone Conjugating Liver Enzymes during Amphibian Metamorphosis?
Christel R. Schopfer,
Franziska Grözinger,
Barbara Birk
и другие.
Regulatory Toxicology and Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 105810 - 105810
Опубликована: Март 1, 2025
Язык: Английский
Pyriproxyfen, villain or good guy? A brief review
Archives of Endocrinology and Metabolism,
Год журнала:
2024,
Номер
68(special issue)
Опубликована: Янв. 1, 2024
Pyriproxyfen
(PPF)
acts
as
a
juvenile
growth
regulator,
interfering
with
normal
metamorphosis
and
blocking
the
development
of
insects
into
adulthood.
Although
World
Health
Organization
(WHO)
considers
use
PPF
at
concentration
0.01
mg/L
unlikely
to
pose
health
risks,
recent
studies
have
unveiled
potential
risks
associated
exposure
non-target
organisms.
Exposure
disrupts
insect
primarily
by
mimicking
hormones;
therefore,
concerns
linger
over
its
impact
on
unintended
species.
Studies
highlighted
adverse
effects
aquatic
invertebrates,
fish,
amphibians
revealed
mortality
developmental
abnormalities
in
mosquito
species
exposed
PPF-treated
water.
Moreover,
may
act
an
endocrine
disruptor,
hormonal
pathways
crucial
for
growth,
reproduction,
behavior
Amphibians,
instance,
display
altered
reproductive
physiology
due
disruptions
signaling
caused
PPF.
The
ecological
ramifications
extend
beyond
direct
toxicity
Indirect
include
shifts
food
web
dynamics
ecosystem
functioning.
Reductions
populations,
induced
PPF,
can
disrupt
availability
higher
trophic
levels,
potentially
destabilizing
community
structure
equilibrium.
Given
mounting
evidence
consequences,
robust
risk
assessment
regulatory
oversight
are
imperative.
Accurate
classification
bodies
is
essential
balancing
role
disease
control
pest
management
benefits
need
safeguard
maintain
health.
Future
research
must
prioritize
comprehensive
assessments
PPF's
across
various
habitats
taxa
inform
evidence-based
policymaking.
Язык: Английский
Assessing plasmatic transport inhibitors of thyroid hormone in mammals in the Xenopus Eleutheroembryonic Thyroid Assay (XETA)
Annika Batel,
Melissa Stilgenbauer,
Inka Marie Spyridonov
и другие.
Environmental Science and Pollution Research,
Год журнала:
2024,
Номер
31(54), С. 63360 - 63373
Опубликована: Ноя. 1, 2024
Язык: Английский
Effects of Diazinon in endocrine disruption: molecular docking and dynamics simulation on hormonal receptors in the context of the extensive use
STUDIES IN ENGINEERING AND EXACT SCIENCES,
Год журнала:
2024,
Номер
5(2), С. e11815 - e11815
Опубликована: Дек. 9, 2024
Diazinon
(DZN)
was
extensively
utilized
as
an
organophosphorus
pesticide
in
developing
countries.
DZN
has
the
ability
to
generate
distinct
metabolites,
namely
diazinon-oxon
(DZNO)
and
2-isopropyl-6-methyl-4-hydroxypyrimidine
(IMHP),
well
non-specific
metabolites
diethylthiophosphate
(DETP)
diethylphosphate
(DEP).
The
aim
of
this
study
use
computational
methods
identify
possible
ways
which
its
main
interact
with
estrogen,
progesterone
estrogen-related
receptors.
This
done
by
silico
molecular
docking.
Molecular
docking
dynamics
simulation
were
conducted
comprehend
interaction
between
diazinon
(DZNO
DETP)
human
Chronic
sublethal
exposure
insecticide
is
known
cause
harmful
effects
on
metabolism
sex
hormones
functioning
nervous
system.
substance
believed
be
endocrine-disrupting
agent
produce
aberrant
patterns
development,
shrinkage
gonads,
issues
neurodevelopment.
produced
during
can
bind
estrogen
receptors,
specifically
receptor
(hPR),
alpha
(ERRα),
gamma
(ERRγ)
(Erα)
beta
(Erβ).
binding
potential
interfere
signaling
humans.
These
compounds
provide
a
danger
interfering
Язык: Английский