The micro(nano)plastics perspective: exploring cancer development and therapy

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Язык: Английский

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Low dose of micro-/nano-plastics mixture induced cardiac hypertrophy and reductive stress: the liver-heart crosstalk and hepatic-cardiac organoids-on-a-chip

Journal of Hazardous Materials, Год журнала: 2025, Номер 490, С. 137686 - 137686

Опубликована: Фев. 20, 2025

Язык: Английский

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Organ-specific accumulation and toxicity analysis of orally administered polyethylene terephthalate microplastics

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 24, 2025

Microplastics (MPs), plastic particles with a diameter of < 5 mm, are intentionally produced or formed by the breakdown variety larger plastics. Polyethylene terephthalate (PET) is common source MPs and PET-MPs prevalent in environment. Owing to their persistence, can enter ecosystems, air, food sources, posing significant health risks. This study aimed investigate toxicological effects vivo accumulation smaller than 10 µm. To track biodistribution, fluorescently labeled were prepared. Particle size morphology confirmed using physical chemical characterization. Following oral administration ICR (CD-1®) outbred mice, occurred predominantly lungs, as IVIS spectrum CT analysis ex imaging. Toxicity assays revealed development granulomatous inflammation lungs at medium high doses, indicating concentration-dependent response. The recorded no-observed-adverse-effect levels 1.75 mg/kg for males 7 females. highlights potential induce persistent respiratory tissues reveals need further research support regulatory standards long-term MP exposure.

Язык: Английский

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Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases

Molecular & Cellular Toxicology, Год журнала: 2025, Номер 21(2), С. 387 - 397

Опубликована: Фев. 27, 2025

Given the global increase in obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) is a major health concern. Because primary organ for xenobiotic metabolism, impact of environmental stressors on homeostasis and MASLD has garnered significant interest over past few decades. The concept metabolism-disrupting chemicals (MDCs) been introduced to underscore importance factors homeostasis. Recent epidemiological biological studies suggest causal link between exposure MDCs prevalence progression MASLD. This review aims introduce emerging their representative toxic mechanisms. In particular, this focuses broadening understanding impacts or steatohepatitis (MASH) progression. research highlighted contaminants, such as heavy metals, microplastics, pesticides, have potential influence hepatic metabolism aggravate MASLD/MASH These not only directly affect lipid hepatocytes but also other cell types, immune cells stellate cells, well gut-liver axis. Collectively, these findings contribute establishing well-defined adverse outcome pathway identify novel therapeutic options diseases associated with pollutants.

Язык: Английский

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Comparative Analysis of Metabolic Dysfunctions Associated with Pristine and Aged Polyethylene Microplastic Exposure via the Liver-Gut Axis in Mice

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 6, 2025

The accumulation of plastic waste in the environment has raised widespread concern about impact microplastics (MPs) on human and environmental health, particularly regarding aged MPs. This study investigated effects subchronic dietary intake pristine polyethylene (PE-MPs) C57BL/6J mice. Results revealed that both PE-MPs, at doses 0.01 1 mg/day, induced plasma metabolic changes primarily associated with lipid metabolism digestive processes. These alterations were reflected expression proteins involved unsaturated fatty acid pathways liver as well a reduction beneficial gut microbiota. Key contributors toxicity PE-MPs included ATP-binding cassette transporters, bacteria (notably Lactobacillus, Akkermansia, Parasutterella, Turicibacter), significantly altered related to elongation, such acyl-CoA thioesterase enzyme family elongation very long chain protein 5. disruptions exacerbated disorders, potentially contributing diseases. Additionally, decreased levels glutathione S-transferase A proteins, along reduced hepatic increased reactive oxygen species small intestine liver, suggested aggravated intestinal damage through oxidative stress. findings indicated caused more severe dysfunction microbiota disruption. effect was likely mediated by transfer acids signaling molecules gut-liver axis, ultimately leading disorders

Язык: Английский

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Amplified lung cancer hazards from surface defects in aged polypropylene microplastics

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163302 - 163302

Опубликована: Май 1, 2025

Язык: Английский

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Toxicological assessments based on intestine 3D organoids reveal environmental low-dose nanosized microplastics (NPs) exposure aggravates radiation-induced intestine injury

Chemosphere, Год журнала: 2024, Номер 370, С. 143922 - 143922

Опубликована: Дек. 18, 2024

Язык: Английский

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