Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage DOI Creative Commons
Faming Jiang, Huang Xiao-yan,

X Chen

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Chemical overexposure is a significant concern in both environmental and occupational settings, often leading to oxidative stress subsequent cellular damage. The review covers the induced by chemical substances such as pesticides (including pyrethroid, deltamethrin, β-cyfluthrin, malathion, triflumuron, methomyl, diquat, cypermethrin, thiamethoxam, profenofos), medications (acetaminophen), nanoparticles zinc oxide, iron, silver, titanium dioxide), heavy metals cadmium, vanadium), some organic chemicals diethylnitrosamine benzo(a)pyrene). Focusing on preclinical evidence from animal models cell-based studies, essential oils have been shown significantly enhance antioxidative enzyme activities, including superoxide dismutase, catalase, glutathione peroxidase, while also increasing levels of non-enzymatic antioxidants uric acid. Additionally, contribute restoration biochemical parameters, creatinine, acid, urea levels, mitigating damage reducing cell membrane injury, apoptosis, histopathological alterations. this evaluates protective benefits against models. underlying mechanism involved alleviating hepatorenal This underscores considerable promise candidates for medicinal applications functional foods or medicines, particularly preventing various overexposure.

Язык: Английский

Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage DOI Creative Commons
Faming Jiang, Huang Xiao-yan,

X Chen

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Chemical overexposure is a significant concern in both environmental and occupational settings, often leading to oxidative stress subsequent cellular damage. The review covers the induced by chemical substances such as pesticides (including pyrethroid, deltamethrin, β-cyfluthrin, malathion, triflumuron, methomyl, diquat, cypermethrin, thiamethoxam, profenofos), medications (acetaminophen), nanoparticles zinc oxide, iron, silver, titanium dioxide), heavy metals cadmium, vanadium), some organic chemicals diethylnitrosamine benzo(a)pyrene). Focusing on preclinical evidence from animal models cell-based studies, essential oils have been shown significantly enhance antioxidative enzyme activities, including superoxide dismutase, catalase, glutathione peroxidase, while also increasing levels of non-enzymatic antioxidants uric acid. Additionally, contribute restoration biochemical parameters, creatinine, acid, urea levels, mitigating damage reducing cell membrane injury, apoptosis, histopathological alterations. this evaluates protective benefits against models. underlying mechanism involved alleviating hepatorenal This underscores considerable promise candidates for medicinal applications functional foods or medicines, particularly preventing various overexposure.

Язык: Английский

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