Contaminants
of
emerging
concern
have
been
highlighted
due
to
their
detrimental
impacts
on
targeted
and
non-targeted
aquatic
species.
Emerging
contaminants
such
as
pharmaceuticals,
synthetic
hormones,
pesticides,
industrial
chemicals
find
way
into
freshwater
streams,
rivers
lakes
eventually
make
the
oceans.
Along
these
dangerous
impact
physiological
processes
species,
causing
serious
biological
damage
they
enter
food-webs.
The
work
described
herein,
involves
development
antibody-based
in-situ
monitoring
systems
for
detection
pharmaceutical
non-steroidal
anti-inflammatory
drug
diclofenac,
which
is
a
biologically
active
compound
that
exerts
various
effects
biochemical
pathways
in
particularly
organisms
when
released
negligently
watercourses.
Environmental Toxicology and Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Abstract
Diclofenac
(DCF)
is
a
nonsteroidal
anti-inflammatory
drug
commonly
used
in
health
care,
livestock,
and
pharmaceuticals
widely
detected
surface
water
environments
globally.
Here,
we
reviewed
the
occurrence
characteristics,
migration
pathways,
aquatic
toxicity
of
DCF
environments.
Asian
African
populations
are
exposed
to
high
concentrations
(>
8,000
ng
L−1).
Wastewater
discharge,
industrial
pollution
primary
factors
influencing
concentration
distribution
DCF.
can
cause
acute
toxicity,
oxidative
stress,
other
toxic
effects
on
organisms.
We
focused
China
analyzed
ecological
risks
found
low
risk
south
north,
as
well
during
rainy
season
dry
season.
Finally,
discuss
removal
methods
for
propose
potential
metal-organic
frameworks
new
material
replace
conventional
removal.
This
study
comprehensively
reveals
status
it
poses
environments,
providing
reference
environmental
management
Environmental Science and Pollution Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 24, 2025
Abstract
Pollution
in
marine
creeks
has
been
increasing
due
to
anthropogenic
activities
and
a
global
concern.
Limited
research
conducted
on
pharmaceuticals
sediment
macroalgae
African
countries.
In
the
present
study,
levels
of
were
assessed
surface
different
species
(
ulvophyceae
;
Cladophora
sudanensis
,
Chaetomorpha
crassa
indica
Enteromorpha
kylinii
Ulva
reticulate
lactuca
sibugae
)
Mombasa
peri-urban
(Tudor,
Makupa
Mtwapa
creek)
Gazi
bay
during
dry
wet
seasons.
The
concentration
seasons
ranged
between
0.04–686.8
ng/g
0.01–2580.6
ng/g,
respectively.
highest
was
observed
Tudor
creek
seasons,
with
sum
∑1013
∑3111
Bay
used
as
reference
environment
for
this
detected
0.10–686.8
0.18–93.5
There
no
seasonal
variation
pharmaceutical
For
species,
below
detection
limit
(DL)–11059
ng/g.
Compared
sediment,
showed
high
Tudor,
creeks.
Tetracycline
higher
all
than
other
compounds.
A
confirms
sewage
effluent
into
creek.
Pharmaceuticals
(acetaminophen,
sulfamethoxazole,
trimethoprim,
carbamazepine
nevirapine)
posed
medium
(−
1
<
Log10
RQ
0)
risk
(Log10
>
algae,
invertebrates
fish
is
need
sensitise
residents
coastal
cities
impact
enact
strict
measures
discharge
effluents
containing
these
contaminants
environment.
Nevertheless,
it
recommended
conduct
further
distribution
long-term
combined
impacts
substances
compounds
biota.
Heliyon,
Год журнала:
2024,
Номер
10(15), С. e34825 - e34825
Опубликована: Июль 18, 2024
In
this
case
study
pharmaceuticals
were
analysed
in
the
Mondego
river
(Portugal)
and
their
environmental
risk
assessed
by
means
of
quotients
based
on
an
extensive
retrieval
ecotoxicological
data
for
freshwater
saltwater
species.
The
crosses
Coimbra,
most
populated
city
Portuguese
Centro
Region
hosting
a
complex
regional
hospitals.
Environmentally
relevant
prioritised
investigated
potential
hazards
evaluated
conducting
separate
assessment
estuary
parts
examined
section.
A
target
analysis
approach
with
method
detection
limits
down
to
0.01
ng
L
Environmental Pollution,
Год журнала:
2022,
Номер
315, С. 120384 - 120384
Опубликована: Окт. 9, 2022
Although
the
presence
of
pharmaceuticals
in
environment
is
an
issue
widely
addressed
research
over
past
two
decades,
still
little
known
about
their
transformation
products.
However,
there
are
indications
that
some
these
chemicals
may
be
equally
or
even
more
harmful
than
parent
compounds.
Diclofenac
(DCF)
among
most
commonly
detected
aquatic
environment,
but
potential
effects
its
metabolites
on
organisms
poorly
understood.
Therefore,
present
study
aimed
to
evaluate
and
compare
toxicity
DCF
metabolite,
4-hydroxy
diclofenac
(4-OH
DCF),
mussels
using
a
multi-biomarker
approach.
Mytilus
trossulus
were
exposed
4-OH
at
68.22
20.85
μg/L
(measured
concentrations
day
0),
respectively,
for
7
days.
In
our
work,
we
showed
both
tested
compounds
have
no
effect
enzymatic
biomarkers
tested.
it
has
been
shown
action
can
affect
protein
content
gills
also
reflected
through
histological
markers.
ENVIRONMENTAL
IMPLICATION:
Studies
recent
years
clearly
prove
negatively
organisms.
addition
compounds,
significant
environmental
problem.
main
diclofenac,
marine
evaluated.
Both
negative
mussels,
which
was
primarily
observed
changes.
The
therefore
confirms
not
only
metabolite
