Children,
Год журнала:
2024,
Номер
11(11), С. 1323 - 1323
Опубликована: Окт. 30, 2024
Neuroblastoma
(NB)
is
the
most
common
type
of
extracranial
solid
tumors
in
children.
Despite
advancements
treatment
strategies
over
past
years,
overall
survival
rate
patients
within
high-risk
NB
group
remains
less
than
50%.
Therefore,
new
options
are
urgently
needed
for
this
patients.
Compared
with
genomic
aberrations,
proteomic
alterations
more
dynamic
and
complex,
as
well
directly
related
to
pathological
phenotypes
external
perturbations
such
environmental
changes
drug
treatments.
This
review
focuses
on
specific
examples
proteomics
application
various
fundamental
aspects
research,
including
tumorigenesis,
treatment,
resistance,
highlights
potential
protein
signatures
signaling
pathways
translational
values
clinical
practice.
Moreover,
emerging
cutting-edge
techniques,
single
cell
spatial
proteomics,
mass
spectrometry
imaging,
discussed
their
potentials
probe
intratumor
heterogeneity
NB.
Authorea (Authorea),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 24, 2024
Environmental
gradients
can
influence
morpho-physiological
and
life-history
differences
in
natural
populations.
It
is
unclear,
however,
to
what
extent
such
also
modulate
phenotypic
other
organismal
characteristics
as
the
structure
function
of
host-associated
microbial
communities.
In
this
work,
we
addressed
question
by
assessing
intra-specific
variation
diversity,
environmental-associated
(sediment
water)
animal-associated
(skin
gut)
microbiota
along
an
environmental
gradient
pollution
one
most
urbanized
coastal
areas
world.
Using
tropical
sea
cucumber
Holothuria
leucospilota,
tested
interplay
between
deterministic
(e.g.,
environmental/host
filtering)
stochastic
random
dispersal)
processes
underpinning
host-microbiome
interactions
assemblages.
Overall,
our
results
indicate
that
communities
are
complex
vary
environment
animal
hosts.
However,
these
modulated
level
across
with
marked
clines
alpha
beta
diversity.
Yet,
overall
showed
opposite
directions
when
comparing
environmental-
cucumbers,
intrinsic
body
compartments,
biochemistry
composition,
immune
systems),
may
underpin
observed
intra-individual
associated
microbiomes,
their
divergence
from
source.
Such
regulation
favours
specific
functional
pathways
play
important
role
survival
physiology
host,
particularly
high
polluted
areas.
These
findings
suggest
both,
host
filtering
underpins
community
assembly
H.
leucospilota
Hong
Kong.
FEMS Microbiology Ecology,
Год журнала:
2024,
Номер
100(5)
Опубликована: Апрель 10, 2024
Abstract
Since
their
radiation
in
the
Middle
Triassic
period
∼240
million
years
ago,
stony
corals
have
survived
past
climate
fluctuations
and
five
mass
extinctions.
Their
long-term
survival
underscores
inherent
resilience
of
corals,
particularly
when
considering
nutrient-poor
marine
environments
which
they
thrived.
However,
coral
bleaching
has
emerged
as
a
global
threat
to
survival,
requiring
rapid
advancements
research
understand
holobiont
stress
responses
allow
for
interventions
before
extensive
occurs.
This
review
encompasses
potential,
well
limits,
multiomics
data
applications
applied
holobiont.
Synopses
how
different
omics
tools
been
date
current
restrictions
are
discussed,
addition
ways
these
may
be
overcome,
such
recruiting
new
technology
studies,
utilizing
novel
bioinformatics
approaches,
generally
integrating
data.
Lastly,
this
presents
considerations
design
studies
support
lab-to-field
marker
monitoring
systems.
Although
much
mechanism
eluded
investigation
date,
multiomic
already
produced
key
findings
regarding
holobiont’s
response,
potential
advance
field
further.
