
Journal of Hazardous Materials, Год журнала: 2023, Номер 458, С. 131904 - 131904
Опубликована: Июнь 21, 2023
Pharmaceuticals
and
microplastics
constitute
potential
hazards
in
aquatic
systems,
but
their
combined
effects
underlying
toxicity
mechanisms
remain
largely
unknown.
In
this
study,
a
simultaneous
characterization
of
bioaccumulation,
associated
metabolomic
alterations
recovery
was
performed.
Specifically,
bioassay
on
Mediterranean
mussels
(Mytilus
galloprovincialis)
carried
out
with
polyethylene
(PE-MPLs,
1
mg/L)
citalopram
or
bezafibrate
(500
ng/L).
Single
co-exposure
scenarios
lasted
21
days,
followed
by
7-day
depuration
period
to
assess
recovery.
PE-MPLs
delayed
the
bioaccumulation
(lower
mean
at
10
d:
447
compared
770
ng/g
dw
under
single
exposure),
although
reaching
similar
tissue
concentrations
after
d.
A
more
limited
accumulation
observed
overall,
regardless
(
Язык: Английский