Environmental Science & Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
Previous
studies
have
demonstrated
the
reproductive
toxicity
of
trifluorostrobin
(TRI)
in
male
organisms.
However,
underlying
mechanisms
TRI
responsible
for
testicular
damage
and
hormonal
disruption
remain
elusive.
This
study
elucidated
at
molecular
level
under
environmentally
relevant
concentrations
its
associations
with
gut
microbiota
dysbiosis.
The
rats
were
administered
(1.5,
15,
75
mg/kg
body
weight/day)
continuously
via
gavage
90
days.
Exposure
to
15
(below
no-observed
adverse
effect
(NOAEL)
30
mg/kg)
damaged
tissue,
reduced
sperm
count,
lowered
serum
hormone
total
cholesterol
levels.
Transcriptomics
analysis
combined
docking
simulations
cell
proliferation
assays
showed
that
exposure
led
by
inhibiting
expression
receptor
genes,
which,
turn,
disrupted
steroid
biosynthesis.
Furthermore,
resulted
a
marked
decline
relative
abundance
probiotic
bacteria.
Consistently,
significant
reductions
short-chain
fatty
acids
(SCFAs),
retinoic
acids,
hormones
observed.
Additionally,
correlation
was
observed
between
Parabacteroides
testosterone
levels,
vital
biomarker
monitoring.
These
findings
shed
light
on
mode
action
TRI-induced
highlight
link
injury
microbiota.
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
290, С. 117788 - 117788
Опубликована: Янв. 1, 2025
Neonicotinoids
exposure
was
found
to
induce
thyroid
dysfunction.
However,
there
lack
of
direct
evidence
between
neonicotinoids
and
hormone
(TH)
disruption
in
population
study,
especially
children,
which
limits
the
understanding
on
their
health
hazard.
To
fill
this
knowledge
gap,
we
conducted
a
cross-sectional
study
children
rural
area
South
China
(n
=
88),
analyzed
urinary
ten
(including
metabolites),
serum
TH,
thyroxine-binding
globulin
(TBG),
stimulating
(TSH)
levels.
Based
linear
regression,
generalized
additive
model,
Bayesian
kernel
machine
levels
were
be
correlated
with
TBG,
TSH
levels,
stronger
effects
for
metabolites
than
parent
compounds
most
cases.
Mixture
had
significantly
positive
effect
free
triiodothyronine
(T3).
N-desmethyl-acetamiprid
(N-dm-ACE)
negatively
associated
T3
female,
corresponded
much
lower
female
male.
Also,
N-dm-ACE
non-monotonic
thyroxine
Some
interactive
lead
cadmium
TH
disruption.
The
results
provide
an
highlight
need
explore
safeguard
children.
Environment International,
Год журнала:
2024,
Номер
189, С. 108811 - 108811
Опубликована: Июнь 10, 2024
China
produces
and
consumes
a
large
amount
of
neonicotinoids.
A
non-negligible
exposure
to
neonicotinoids
might
occur
for
Chinese
pregnant
women,
but
relevant
data
remain
limited.
To
investigate
the
by
urinary
biomonitoring
in
women
from
Wenzhou
City,
East
China.
We
selected
432
City
2022.
total
eight
parent
four
metabolites
were
determined
single
spot
urine
liquid
chromatography
coupled
mass
spectrometry.
Basic
characteristics,
physical
activity,
pre-pregnant
body
index,
intake
drinking
water
food
investigated
questionnaire.
Health
risk
was
assessed
hazard
quotient
(HQ)
index
(HI)
based
on
human
safety
thresholds
derived
different
health
endpoints.
Neonicotinoids
their
had
detection
frequency
between
0
%
80.1
%.
At
least
one
neonicotinoid
or
metabolite
detected
93.5
samples.
Except
clothianidin
(51.2
%)
N-desmethyl-acetamiprid
(80.1
%),
frequencies
other
ranged
43.8
The
summed
concentrations
all
<
LOD
222.83
μg/g
creatinine
with
median
concentration
2.58
creatinine.
Maternal
age,
educational
level,
occupation,
household
income,
screen
time,
associated
metabolites.
Pregnant
higher
consumption
wheat,
fresh
vegetable,
shellfish,
milk,
powdered
milk
Both
HQ
HI
less
than
one.
Overall,
showed
notable
at
neonicotinoid,
although
each
specific
generally
low.
Several
items
plants
animals
potential
sources.
low
found
current
thresholds.
Chinese Journal of Chromatography,
Год журнала:
2024,
Номер
42(2), С. 217 - 223
Опубликована: Фев. 1, 2024
Rapid
industrial
and
agricultural
developments
in
China
have
led
to
the
wide
use
discharge
of
chemical
products
pesticides,
resulting
extensive
residues
environmental
media.
These
can
enter
human
body
through
various
pathways,
leading
high
exposure
risks
health
hazards.
Because
is
exposed
a
variety
pollutants,
accurately
quantifying
levels
these
pollutants
evaluating
their
are
great
importance.
In
this
study,
serum
concentrations
97
typical
60
adults
central
were
simultaneously
determined
using
solid-phase
extraction
coupled
with
gas
chromatography-tandem
mass
spectrometry
(SPE-GC-MS/MS).
method,
200
μL
sample
was
mixed
10
an
isotope-labeled
internal
standard
solution.
The
vortexed
refrigerated
overnight
at
4
℃.
Each
then
deproteinized
by
addition
15%
formic
acid
aqueous
solution
vortexed.
loaded
into
preconditioned
Oasis
