Toxicology of Nanomaterials With a Special Focus on the Nervous System DOI
Bancha Yingngam

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Год журнала: 2024, Номер unknown, С. 27 - 64

Опубликована: Окт. 11, 2024

Nanomaterials possess different properties that make them suitable for application in numerous fields. Nonetheless, their toxicity, especially neurotoxic propensity, is a considerable area of investigation. In this chapter, nanomaterial neurotoxicity reviewed detail, with an emphasis on assessing levels exposure or routes entry to brain cells, mechanisms by which they cause damage, and specific types damage. addition, vitro, ex vivo, vivo models used measure are described. This chapter provides discussion matter considering challenges terms characterization, risk assessment, regulatory aspects. concludes underscoring the importance toxicological prediction safe-by-design solutions. Future research should address long-term effects using nanomaterials means preventing neurotoxicity.

Язык: Английский

Cardiotoxicity induced by xanthatin via activating apoptosis and ERS pathways in zebrafish DOI

Lixin Feng,

Liyan Xu,

Jing Huang

и другие.

Drug and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Март 24, 2025

Xanthatin, a sesquiterpene lactone compound, isolated from Chinese herb, Xanthium strumarium L, has various activities, including anti-inflammatory, anti-tumor, anti-ulcer effects. However, it been less studied in terms of its toxicity, especially the potential toxicity on heart. This study is mainly aimed to assess cardiotoxicity xanthatin vivo using zebrafish larva and vitro cardiomyocytes H9C2. The was assessed by pericardial edema, blood flow dynamics, SV-BA distance, sub-intestinal vein. apoptosis determined AO staining, red cell reduction distribution detected O-dianisidine histopathological evaluations were HE staining. anti-proliferative pro-apoptotic activities H9C2 cells EdU staining Hoechst 33342/PI double results showed that caused cardiac malformations dysfunctions, decreased heart rate, reduced count, hemodynamics, stroke volume, increased distance vein congestion. Furthermore, occurred after exposure. Additionally, cat, Mn-sod, chop, perk, hspa5 related oxidative stress ERS also changed xanthatin. Apoptotic genes caspase3 caspase9 increased. Moreover, had proapoptotic antiproliferative To sum up, these suggest stress, pathways are involved induced finding will be helpful for better understanding underlying mechanism.

Язык: Английский

Процитировано

0
Effects of Exposure to Bauxite Residue Leachates from Short-Term Revegetation on Oxidative Stress and DNA Damage in Zebrafish (Danio rerio) DOI

Zuyan Wan,

Yi Lou, Yulu Chen

и другие.

Water Air & Soil Pollution, Год журнала: 2025, Номер 236(5)

Опубликована: Апрель 8, 2025

Язык: Английский

Процитировано

0
Triclosan Induces Neurodevelopmental Toxicity Mediated by Circrna266/Mir-214 Regulatory Networks in Larval Zebrafish DOI
Huili Wang, Zejun Wang, Xiaowen Han

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Toxicology of Nanomaterials With a Special Focus on the Nervous System DOI
Bancha Yingngam

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Год журнала: 2024, Номер unknown, С. 27 - 64

Опубликована: Окт. 11, 2024

Nanomaterials possess different properties that make them suitable for application in numerous fields. Nonetheless, their toxicity, especially neurotoxic propensity, is a considerable area of investigation. In this chapter, nanomaterial neurotoxicity reviewed detail, with an emphasis on assessing levels exposure or routes entry to brain cells, mechanisms by which they cause damage, and specific types damage. addition, vitro, ex vivo, vivo models used measure are described. This chapter provides discussion matter considering challenges terms characterization, risk assessment, regulatory aspects. concludes underscoring the importance toxicological prediction safe-by-design solutions. Future research should address long-term effects using nanomaterials means preventing neurotoxicity.

Язык: Английский

Процитировано

0