Hexavalent chromium induces ferroptosis in small intestinal tissue of broilers through GPX4/HMGB1/p38-MAPK pathway

Poultry Science, Год журнала: 2025, Номер 104(4), С. 104978 - 104978

Опубликована: Март 3, 2025

As a major environmental heavy metal pollutant, hexavalent chromium (Cr(VI)) causes irreversible damage to animals and humans. Nevertheless, how Cr(VI) exposure intestinal in broilers remains inadequately explored. This study explores Cr(VI)-induced poisoning using potassium dichromate build model. The results indicate that evidently reduced the body weight functions of liver kidney broilers. Histopathological analysis revealed different degrees structural all three segments small intestines by exposure. Moreover, downregulated ZO-1, Occludin, Claudin-1, while altering diversity cecal microbiota impair barrier function. Additionally, with increasing concentration, contents Fe2+, ROS, LPO showed dose-dependent increase. levels GPX4, SLC7A11, FTL, FTH1 were Cr(VI), p38-MAPK, phosphorylated p38, TFR1, HMGB1 upregulated. suggests ROS can trigger ferroptosis through GPX4/HMGB1/p38-MAPK pathway, leading dysfunction ultimately reducing production performance provides foundation theory for understanding effects on intestine.

Язык: Английский

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Nuclear receptor coactive 4-mediated ferritinophagy: a key role of heavy metals toxicity

Archives of Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Язык: Английский

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Effect of Interaction of ATG7 and Plasma Metal Concentrations on Cognitive Impairment in Rural China

Journal of Molecular Neuroscience, Год журнала: 2025, Номер 75(1)

Опубликована: Фев. 24, 2025

Язык: Английский

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Gestational and lactational exposure to DEHP triggers ACSL4/TFR-mediated hippocampal neuronal ferroptosis via YAP activation: implication for the neurocognitive disorders in male offspring

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138081 - 138081

Опубликована: Март 1, 2025

Язык: Английский

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Cadmium treatment induces oxidative damage and apoptosis in vitro skeletal muscle cells

Toxicology, Год журнала: 2025, Номер unknown, С. 154139 - 154139

Опубликована: Апрель 1, 2025

Язык: Английский

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Short-term respiratory cadmium exposure partially activates pulmonary NLRP3 inflammasome by inducing ferroptosis in mice

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 285, С. 117106 - 117106

Опубликована: Сен. 25, 2024

Язык: Английский

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Acute waterborne cadmium exposure induces liver ferroptosis in Channa argus

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 283, С. 116947 - 116947

Опубликована: Авг. 29, 2024

The impact of cadmium (Cd) toxicity on fish liver injury has received much attention in recent years. Currently, autophagy, apoptosis and endoplasmic reticulum stress were reported Cd exposed liver, if there are other mechanisms (such as ferroptosis) relevant signaling pathways involved remains unknown. An experiment was conducted to investigate Channa argus (Cantor, 1842) 0, 1.0, 2.0 mg Cd/L water for 96 h. disrupted the structure mitochondria liver. Besides, induced ferroptosis by significantly increasing level Fe

Язык: Английский

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Ellagic Acid Reduces Cadmium Exposure-Induced Apoptosis in HT22 Cells via Inhibiting Oxidative Stress and Mitochondrial Dysfunction and Activating Nrf2/HO-1 Pathway

Antioxidants, Год журнала: 2024, Номер 13(11), С. 1296 - 1296

Опубликована: Окт. 25, 2024

Exposure to cadmium sulfate (CdSO

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Dietary interventions in mitigating the impact of environmental pollutants on Alzheimer’s disease – A review

Neuroscience, Год журнала: 2024, Номер 563, С. 148 - 166

Опубликована: Ноя. 13, 2024

Язык: Английский

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The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradation

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 290, С. 117542 - 117542

Опубликована: Дек. 18, 2024

Язык: Английский

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