Associations of Environmental Exposure to Arsenic, Manganese, Lead, and Cadmium with Alzheimer’s Disease: A Review of Recent Evidence from Mechanistic Studies DOI Creative Commons
Giasuddin Ahmed, Md. Shiblur Rahaman, Enrique Perez

и другие.

Journal of Xenobiotics, Год журнала: 2025, Номер 15(2), С. 47 - 47

Опубликована: Март 24, 2025

Numerous epidemiological studies indicate that populations exposed to environmental toxicants such as heavy metals have a higher likelihood of developing Alzheimer’s disease (AD) compared those unexposed, indicating potential association between exposure and AD. The aim this review is summarize contemporary mechanistic research exploring the associations four important metals, arsenic (As), manganese (Mn), lead (Pb), cadmium (Cd), with AD possible pathways, processes, molecular mechanisms on basis data from most recent studies. Primary publications published during last decade were identified via search PubMed Database. A thorough literature final screening yielded 45 original articles for review. Of articles, 6 pertain As, 9 Mn, 21 Pb, Cd exposures pathobiology. Environmental these induces wide range pathological processes intersect well-known leading AD, oxidative stress, mitochondrial dysfunction, protein aggregation, neuroinflammation, autophagy tau hyperphosphorylation. While single shares some affected certain effects are unique specific metals. For instance, Pb disrupts blood–brain barrier (BBB) functions alters AD-related genes epigenetically. triggers neuronal senescence p53/p21/Rb. As nitric oxide (NO) signaling, cortical, synaptic function. Mn causes glutamate excitotoxicity dopamine neuron damage. Our provides deeper understanding biological showing how contribute Information regarding metal-induced toxicity relevant may help us develop effective therapeutic intervention, treatment, prevention.

Язык: Английский

Based on the Sam50-MICOS-ATAD3-mtDNA axis: Exploring oligomeric proanthocyanidins to alleviate molybdenum and cadmium co-induced liver inflammation in sheep DOI

Maokang Liu,

Junhua Ye, Fan Yang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141035 - 141035

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Associations of Environmental Exposure to Arsenic, Manganese, Lead, and Cadmium with Alzheimer’s Disease: A Review of Recent Evidence from Mechanistic Studies DOI Creative Commons
Giasuddin Ahmed, Md. Shiblur Rahaman, Enrique Perez

и другие.

Journal of Xenobiotics, Год журнала: 2025, Номер 15(2), С. 47 - 47

Опубликована: Март 24, 2025

Numerous epidemiological studies indicate that populations exposed to environmental toxicants such as heavy metals have a higher likelihood of developing Alzheimer’s disease (AD) compared those unexposed, indicating potential association between exposure and AD. The aim this review is summarize contemporary mechanistic research exploring the associations four important metals, arsenic (As), manganese (Mn), lead (Pb), cadmium (Cd), with AD possible pathways, processes, molecular mechanisms on basis data from most recent studies. Primary publications published during last decade were identified via search PubMed Database. A thorough literature final screening yielded 45 original articles for review. Of articles, 6 pertain As, 9 Mn, 21 Pb, Cd exposures pathobiology. Environmental these induces wide range pathological processes intersect well-known leading AD, oxidative stress, mitochondrial dysfunction, protein aggregation, neuroinflammation, autophagy tau hyperphosphorylation. While single shares some affected certain effects are unique specific metals. For instance, Pb disrupts blood–brain barrier (BBB) functions alters AD-related genes epigenetically. triggers neuronal senescence p53/p21/Rb. As nitric oxide (NO) signaling, cortical, synaptic function. Mn causes glutamate excitotoxicity dopamine neuron damage. Our provides deeper understanding biological showing how contribute Information regarding metal-induced toxicity relevant may help us develop effective therapeutic intervention, treatment, prevention.

Язык: Английский

Процитировано

0