A complex association with cadmium
Nature Reviews Urology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Язык: Английский
Association between exposure to blood heavy metal mixtures and overactive bladder risk among U.S. adults: a cross-sectional study
Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Июнь 4, 2025
Background
Increasing
evidence
has
demonstrated
that
exposure
to
environmental
heavy
metals
harms
human
health.
However,
information
regarding
the
impact
of
co-exposure
metal
mixtures
on
risk
overactive
bladder
(OAB)
was
limited.
Our
study
aimed
explore
joint
effects
blood
OAB
risk.
Methods
Data
for
this
were
obtained
from
four
National
Health
and
Nutrition
Examination
Survey
cycles
(2011–2018).
The
single
explored
using
multivariate
logistic
regression.
Additionally,
we
used
weighted
quantile
sum
(WQS),
quantile-based
g
computation
(qgcomp),
Bayesian
kernel
machine
regression
(BKMR)
models
combined
effect
Age-stratified
subgroup
analyses
conducted,
restricted
cubic
splines
(RCS)
utilized
investigate
non-linear
relationship
between
OAB.
Results
A
total
4,183
individuals
aged
20–80
years
included
further
study.
Among
them,
866
(20.7%)
participants
had
patients
significantly
higher
concentrations
cadmium
(Cd)
lead
lower
selenium
manganese
than
those
without
(all
p
<
0.05).
In
single-metal
analyses,
Cd
increased
mixed-exposure
WQS
BKMR
consistently
revealed
a
significant
positive
association
risk,
identifying
as
main
driver.
young/middle-aged
group
exhibited
similar
associations.
mixtures,
top-weighted
entire
population
individuals,
whereas
mercury
(Hg)
held
highest
weight
among
older
adult
individuals.
Furthermore,
observed
an
underlying
interaction
Hg
in
model.
sensitivity
findings
qgcomp
model
validated
toxic
According
RCS
regression,
identified
linear
dose–response
Conclusion
related
Further
research
prioritizing
low-dose,
real-world
vulnerable
populations
(e.g.,
adult,
high-risk
occupations)
is
essential
translate
our
into
preventive
strategies
regulatory
policies.
Язык: Английский
Endocrine disruptors and bladder function: the role of phthalates in overactive bladder
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 11, 2024
Background
Phthalates,
widely
used
as
plasticizers,
are
pervasive
environmental
contaminants
and
endocrine
disruptors.
Their
potential
role
in
overactive
bladder
(OAB)
pathogenesis
is
underexplored,
necessitating
further
investigation
into
their
impact
on
OAB
using
large-scale
epidemiological
data.
Methods
This
study
utilized
data
from
the
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2011
to
2018.
A
weighted
multivariable
logistic
regression
model
was
employed
examine
relationship
between
urinary
phthalate
concentrations
OAB.
Subgroup
analyses
were
conducted
explore
differences
associations
across
various
subgroups.
Restricted
cubic
spline
(RCS)
analysis
investigate
non-linear
Additionally,
Bayesian
Kernel
Machine
Regression
(BKMR)
performed
overall
effects
interactions
of
mixtures.
Results
In
fully
adjusted
for
confounding
variables,
higher
MBzP
MiBP
associated
with
an
increased
risk
OAB,
particularly
highest
tertiles
(MBzP:
OR
=
1.401,
95%
CI:
1.108–1.771;
MiBP:
1.050,
1.045–1.056).
found
that
subgroup
characteristics
did
not
have
a
significant
moderating
effect
association
phthalates
RCS
revealed
linear
both
BKMR
confirmed
positive
mixtures
risk,
identified
major
contributing
factor.
Conclusion
our
cohort,
correlation
observed,
research
validate
refine
this
conclusion.
Язык: Английский