Environmental Science & Technology,
Год журнала:
2023,
Номер
57(26), С. 9722 - 9731
Опубликована: Июнь 23, 2023
As
typical
persistent
organic
pollutants,
polybrominated
diphenyl
ethers
(PBDEs)
tend
to
accumulate
in
edible
parts
of
rice,
posing
great
ecological
and
health
risks.
The
translocation
PBDEs
from
underground
aboveground
rice
is
a
crucial
procedure
determine
the
final
bioaccumulation
level.
Herein,
this
study
aimed
identify
transporter
proteins
for
plants
order
strengthen
our
understanding
mechanism
potential
prevention
strategy
PBDE
risk.
Similar
time-dependent
patterns
were
observed
among
root-to-shoot
factors
(TFs)
PBDEs,
expression
lysine
histidine
(LHT)
protein,
relative
levels
LHT
substrates
(phenylalanine
or
tyrosine),
implying
co-transport
phenylalanine,
tyrosine
by
carrier
LHT.
Fluorescence
spectra
circular
dichroism
showed
that
congeners
interfered
with
via
static
fluorescence
quenching
changes
protein's
secondary
structure.
vitro
sorption
fraction
as
revealed
equilibrium
analysis,
was
comparable
vivo
TF
values.
Knockout
OsLHT1
using
CRISPR/Cas9
technology
caused
48.2–78.4%
decrease
translocation.
Molecular
docking
simulation
suggested
inserted
into
same
ligand-binding
cavity
LHT,
substantiating
role
conformational
perspective.
Quantitative
structure
activity
relationship
analysis
demonstrated
ether-bond
oxygen
carbons
at
site
4
4′
molecules
are
significant
determinants
binding
affinity
protein
PBDEs.
In
summary,
discovered
acts
cellular
offered
comprehensive
molecular
explanation
plants,
covering
both
biological
chemical
perspectives.
These
findings
fill
knowledge
gap
on
endogenous
exogenous
pollutants.
International Journal of Obesity,
Год журнала:
2024,
Номер
48(4), С. 449 - 460
Опубликована: Янв. 11, 2024
Despite
varied
treatment,
mitigation,
and
prevention
efforts,
the
global
prevalence
severity
of
obesity
continue
to
worsen.
Here
we
propose
a
combined
model
obesity,
unifying
paradigm
that
links
four
general
models:
energy
balance
(EBM),
based
on
calories
as
driver
weight
gain;
carbohydrate-insulin
(CIM),
insulin
storage;
oxidation-reduction
(REDOX),
reactive
oxygen
species
(ROS)
altered
metabolic
signaling;
obesogens
(OBS),
which
proposes
environmental
chemicals
interfere
with
hormonal
signaling
leading
adiposity.
We
OBS/REDOX
in
(in
air,
food,
food
packaging,
household
products)
generate
false
autocrine
endocrine
signals,
including
ROS,
subvert
standard
regulatory
mechanisms,
increase
basal
stimulated
secretion,
disrupt
efficiency,
influence
appetite
expenditure
gain.
This
incorporates
data
supporting
EBM
CIM
models,
thus
creating
one
integrated
covers
significant
aspects
all
mechanisms
potentially
contributing
pandemic.
Importantly,
provides
rationale
approach
for
future
preventative
efforts
chemical
exposure
reduction.
Microorganisms,
Год журнала:
2025,
Номер
13(1), С. 155 - 155
Опубликована: Янв. 14, 2025
Although
bioremediation
is
considered
the
most
environmentally
friendly
and
sustainable
technique
for
remediating
contaminated
soil
water,
it
effective
when
combined
with
physicochemical
methods,
which
allow
preliminary
removal
of
large
quantities
pollutants.
This
allows
microorganisms
to
efficiently
eliminate
remaining
contaminants.
In
addition
requiring
necessary
genes
degradation
pathways
specific
substrates,
as
well
tolerance
adverse
environmental
conditions,
may
perform
below
expectations.
One
typical
reason
this
high
toxicity
xenobiotics
present
in
concentrations,
stemming
from
vulnerability
bacteria
introduced
a
site.
especially
true
planktonic
bacteria,
whereas
within
biofilms
or
microcolonies
have
significant
advantages
over
their
counterparts.
A
physical
matrix
essential
formation,
maintenance,
survival
bacterial
biofilms.
By
providing
such
immobilization,
formation
can
be
facilitated
accelerated.
Therefore,
immobilization
offers
comprehensive
solution
cleanup
by
harnessing
specialized
metabolic
activities
while
ensuring
retention
efficacy
at
target
sites.
many
cases,
also
need
methods
that
are
otherwise
required
initially
reduce
contaminant
concentrations.
Then,
will
possible
use
remediation
higher
concentrations
xenobiotics,
significantly
reducing
costs
maintaining
rapid
rate
processes.
review
explores
benefits
highlighting
materials
processes
developing
an
optimal
matrix.
It
focuses
on
following
four
key
areas:
(i)
types
organic
pollutants
impacting
human
health,
(ii)
strains
used
processes,
(iii)
(iv)
cells
various
carriers
targeted
pollutant
degradation.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(19), С. 11899 - 11899
Опубликована: Окт. 7, 2022
Thousands
of
natural
or
manufactured
chemicals
were
defined
as
endocrine-disrupting
(EDCs)
because
they
can
interfere
with
hormone
activity
and
the
endocrine
system.
We
summarize
discuss
what
we
know
still
need
to
learn
about
EDCs'
pathogenic
mechanisms
action,
well
effects
most
common
EDCs
on
system
health
in
childhood.
The
MEDLINE
database
(PubMed)
was
searched
13
May
2022,
filtering
for
EDCs,
diseases,
children.
are
a
group
compounds
high
heterogeneity,
but
usually
disrupt
by
mimicking
interfering
hormones
body's
hormonal
balance
through
other
mechanisms.
Individual
studied
detail,
while
humans'
"cocktail
effect"
is
unclear.
In
utero,
early
postnatal
life,
and/or
pubertal
development
highly
susceptible
periods
exposure.
Human
epidemiological
studies
suggest
that
affect
prenatal
growth,
thyroid
function,
glucose
metabolism,
obesity,
puberty,
fertility
several
Further
needed
clarify
which
mainly
act
epigenetic
processes.
A
better
understanding
human
crucial
developing
future
regulatory
strategies
prevent
exposure
ensure
children
today,
generations,
environment.
Cells,
Год журнала:
2022,
Номер
12(1), С. 174 - 174
Опубликована: Дек. 31, 2022
Polycystic
ovary
syndrome
(PCOS)
is
the
most
common
heterogeneous
endocrine
disorder
among
women
of
reproductive
age.
The
pathogenesis
PCOS
remains
elusive;
however,
there
evidence
suggesting
potential
contribution
genetic
interactions
or
predispositions
combined
with
environmental
factors.
Among
these,
disrupting
chemicals
(EDCs)
have
been
proposed
to
potentially
contribute
etiology
PCOS.
Granulosa
and
theca
cells
are
known
cooperate
maintain
ovarian
function,
any
disturbance
can
lead
disorders,
such
as
This
article
provides
a
review
recent
knowledge
on
pathophysiology,
role
granulosa
in
pathogenesis,
linking
exposure
EDCs
disorders
