Fluoride exposure and cognitive neurodevelopment: Systematic review and dose-response meta-analysis

Environmental Research, Год журнала: 2023, Номер 221, С. 115239 - 115239

Опубликована: Янв. 10, 2023

Many uncertainties still surround the possible harmful effect of fluoride exposure on cognitive neurodevelopment in children. The aim this systematic review and meta-analysis was to characterize relation through a dose-response approach, by comparing intelligence quotient (IQ) scores highest versus lowest category with random-effects model, within one-stage based cubic spline model. Out 1996 potentially relevant literature records, 33 studies were eligible for review, 30 which also suitable meta-analysis. summary mean difference IQ score, categories considering all types exposure, -4.68 (95% confidence interval-CI -6.45; -2.92), value -5.60 CI -7.76; -3.44) drinking water -3.84 -7.93; 0.24) urinary fluoride. Dose-response analysis showed substantially linear decrease increasing above 1 mg/L, -3.05 -4.06; -2.04) points per mg/L up 2 becoming steeper such level. A weaker -2.15 -4.48; 0.18) emerged 0.28 (approximately reflecting content 0.7 mg/L). inverse association between particularly strong at high risk bias, while no adverse only study judged low bias. Overall, most suggested an children's IQ, starting levels exposure. However, major role residual confounding could not be ruled out, thus indicating need additional prospective bias conclusively assess neurodevelopment.

Язык: Английский

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Systematic review of epidemiological and toxicological evidence on health effects of fluoride in drinking water

Critical Reviews in Toxicology, Год журнала: 2024, Номер 54(1), С. 2 - 34

Опубликована: Янв. 2, 2024

Introduction Fluoride is a naturally occurring substance that also added to drinking water, dental hygiene products, and food supplements for preventing caries. Concerns have been raised about several other potential health risks of fluoride.

Язык: Английский

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Fluoride Exposure and Children’s IQ Scores

JAMA Pediatrics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Importance Previous meta-analyses suggest that fluoride exposure is adversely associated with children’s IQ scores. An individual’s total comes primarily from in drinking water, food, and beverages. Objective To perform a systematic review meta-analysis of epidemiological studies investigating scores prenatal or postnatal exposure. Data Sources BIOSIS, Embase, PsycInfo, PubMed, Scopus, Web Science, CNKI, Wanfang, searched through October 2023. Study Selection Studies reporting scores, exposure, effect sizes. Extraction Synthesis were extracted into the Health Assessment Workplace Collaborative system. quality was evaluated using OHAT risk-of-bias tool. Pooled standardized mean differences (SMDs) regression coefficients estimated random-effects models. Main Outcomes Measures Children’s Results Of 74 included (64 cross-sectional 10 cohort studies), most conducted China (n = 45); other locations Canada 3), Denmark 1), India 12), Iran 4), Mexico New Zealand Pakistan 2), Spain Taiwan 1). Fifty-two rated high risk bias 22 low bias. Sixty-four reported inverse associations between measures IQ. Analysis 59 group-level dental fluorosis, (47 bias, 12 bias; n 20 932 children) showed an association (pooled SMD, −0.45; 95% CI, −0.57 to −0.33; P < .001). In 31 measured dose-response found exposed reference groups (SMD, −0.15; −0.20 −0.11; .001), remained when restricted less than 4 mg/L 2 mg/L; however, null at 1.5 mg/L. analyses studies, mg/L, water. urine, there −0.23 −0.07; Associations urine; held studies. 13 individual-level score decrease 1.63 points (95% −2.33 −0.93; .001) per 1-mg/L increase urinary fluoride. Among 1.14 –1.68 –0.61; stratified by sex, age, outcome assessment type, country, timing, matrix. Conclusions Relevance This measurements urine water across large multicountry literature. There limited data uncertainty alone concentrations These findings may inform future comprehensive public health risk-benefit assessments exposures.

Язык: Английский

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Maternal Urinary Fluoride and Child Neurobehavior at Age 36 Months

JAMA Network Open, Год журнала: 2024, Номер 7(5), С. e2411987 - e2411987

Опубликована: Май 20, 2024

Recent studies in Canadian and Mexican populations suggest an association of higher prenatal fluoride exposure with poorer neurobehavioral development, but whether this holds for US-based is unknown.

Язык: Английский

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The role of mTORC1/TFEB axis mediated lysosomal biogenesis and autophagy impairment in fluoride neurotoxicity and the intervention effects of resveratrol

Journal of Hazardous Materials, Год журнала: 2024, Номер 467, С. 133634 - 133634

Опубликована: Янв. 28, 2024

Язык: Английский

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Associations of gestational and childhood exposure to lead, cadmium, and fluoride with cognitive abilities, behavior, and social communication at 4 years of age: NICE birth cohort study

Environmental Research, Год журнала: 2024, Номер 263, С. 120123 - 120123

Опубликована: Окт. 9, 2024

Early-life lead exposure affects cognitive development and emerging evidence suggests similar effects of cadmium fluoride.

Язык: Английский

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Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies

European Journal of Public Health, Год журнала: 2023, Номер unknown

Опубликована: Сен. 18, 2023

Abstract Background Fluoride may be a developmental neurotoxicant at elevated exposures. We merged new data from prospective Odense Child Cohort (OCC) with results two previous birth cohort studies Mexico and Canada to characterize the dose–effect relationship in greater detail. Methods The OCC contributed 837 mother–child pairs total of >1500. measured creatinine-adjusted urine-fluoride concentrations maternal urine samples obtained during late pregnancy. IQ was determined age 7 years using an abbreviated version Wechsler Intelligence Scales for Children. Findings three cohorts were used calculate joint benchmark concentration (BMC) lower confidence limit (BMCL) after adjustment covariables. Results In OCC, varied between 0.08 3.04 mg/l (median 0.52 mg/l) but not significantly associated full-scale (β = 0.08; 95% interval −1.14 1.30 doubling exposure). No difference apparent boys girls. BMC 0.92 mg/l, BMCL 0.30 mg/l. analysis all showed statistically significant association IQ, 0.45 (BMCL, 0.28 mg/l), slightly higher than previously reported North American alone. Conclusions As reflects approximate threshold neurotoxicity, suggest that pregnant women children need protection against fluoride toxicity.

Язык: Английский

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Focus on cognitive impairment induced by excessive fluoride: An update review

Neuroscience, Год журнала: 2024, Номер 558, С. 22 - 29

Опубликована: Авг. 11, 2024

Язык: Английский

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A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment

Advances in Nutrition, Год журнала: 2023, Номер 14(2), С. 317 - 338

Опубликована: Фев. 1, 2023

Iodine (I), an essential nutrient, is important for thyroid function and therefore growth development. Fluoride (F), also strengthens bones teeth, prevents childhood dental caries. Both severe mild-to-moderate I deficiency high F exposure during development are associated to decreased intelligence quotient with recent reports associating levels of pregnancy infancy low quotient. halogens, it has been suggested that may interfere the role in function. We provide a scoping review literature on dur their individual effects offspring neurodevelopment. first discuss intake status relationship follow then interaction between searched for, found only one study assessed both pregnancy. conclude more studies needed.

Язык: Английский

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Fluoride exposure during puberty induces testicular impairment via ER Stress-triggered apoptosis in mice

Food and Chemical Toxicology, Год журнала: 2024, Номер 189, С. 114773 - 114773

Опубликована: Май 31, 2024

Язык: Английский

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