Nano Materials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Cancer
treatment
often
requires
a
multimodal
approach,
such
as
combining
chemotherapy
and
gene
therapy.
However,
challenges
low
therapeutic
efficacy
off-target
effects
hinder
the
effectiveness
of
these
treatments.
In
this
study,
use
calcium-doped
metal-organic
frameworks
Cu2(BDC)2(DABCO)
nanocarrier
platform
for
co-delivery
doxorubicin
(DOX)
plasmid
CRISPR
(pCRISPR)
proposed
to
enhance
anticancer
efficiency.
We
demonstrated
that
Ca-doped
MOF
nanocarriers
significantly
improved
uptake
DOX
pCRISPR
by
in
cancer
cells.
The
with
resulted
significant
rise
cell
death
decreased
targeted
expression.
Environmental Research,
Год журнала:
2023,
Номер
239, С. 117292 - 117292
Опубликована: Окт. 6, 2023
Combination
therapy
has
been
considered
one
of
the
most
promising
approaches
for
improving
therapeutic
effects
anticancer
drugs.
This
is
first
study
that
uses
two
different
antioxidants
in
full-characterized
niosomal
formulation
and
thoroughly
evaluates
their
synergistic
on
breast
cancer
cells.
In
this
study,
in-silico
studies
hydrophilic
hydrophobic
drugs
(ascorbic
acid:
Asc
curcumin:
Cur)
interactions
release
were
investigated
validated
by
a
set
vitro
experiments
to
reveal
significant
improvement
using
co-delivery
approach
nanocarrier.
The
nanoparticles
containing
surfactants
(Span
60
Tween
60)
cholesterol
at
2:1
M
ratio
prepared
through
film
hydration
method.
A
systematic
evaluation
nanoniosomes
was
carried
out.
profile
demonstrated
phases
(initial
burst
followed
sustained
release)
pH-dependent
schedule
over
72
h.
optimized
preparation
displayed
superior
storage
stability
up
2
months
4
°C,
exhibiting
extremely
minor
changes
pharmaceutical
encapsulation
efficiency
size.
Free
dual
(Asc
+
dual-drug
loaded
niosomes
(Niosomal
Cur))
enhanced
apoptotic
activity
cytotoxicity
inhibited
cell
migration
which
confirmed
effect
co-encapsulated
Also,
up-regulation
p53
Bax
genes
observed
cells
treated
with
Cur
Niosomal
Cur),
while
anti-apoptotic
Bcl-2
gene
down-regulated.
These
results
correlation
increase
enzyme
SOD,
CAT,
caspase,
levels
malondialdehyde
(MDA)
reactive
oxygen
species
(ROS)
upon
treatment
mentioned
Furthermore,
these
anti-cancer
higher
when
than
Cur.
Histopathological
examination
also
revealed
had
lower
mitosis
index,
invasion,
pleomorphism
findings
indicated
would
offer
delivery
system
an
effective
treatment.
Alexandria Engineering Journal,
Год журнала:
2023,
Номер
86, С. 577 - 583
Опубликована: Дек. 14, 2023
The
presence
of
antibiotics
in
wastewater
has
become
a
significant
concern
due
to
their
potential
environmental
impact
and
contribution
antibiotic
resistance.
In
this
study,
we
investigated
the
degradation
tetracycline,
commonly
used
antibiotic,
using
system
based
on
zero-valent
nano
iron
assisted
micro-nano
bubbles
(MB/nZVI).
synthesized
nZVI-BC
composite,
consisting
particles
loaded
onto
phosphoric
acid-activated
biochar,
served
as
an
efficient
adsorbent
for
tetracycline
removal.
Our
findings
revealed
that
combination
MBs
nZVI
significantly
enhanced
efficiency
tetracycline.
MB/nZVI
exhibited
highest
removal
rate
82.81%
after
2
h
reaction,
surpassing
performance
MB
alone,
conventional
bubble
(CB)/nZVI-BC
systems.
Furthermore,
showed
superior
at
dosage
25
g/L
flow
30
mL/min.
pH
condition
had
no
effect
system.
results
demonstrate
use
be
sustainable
approach
remediation
tetracycline-contaminated
wastewater.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117118 - 117118
Опубликована: Июль 14, 2024
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
prevalent
malignant
tumors
in
contemporary
era,
representing
a
significant
global
health
concern.
Early
HCC
patients
have
mild
symptoms
or
are
asymptomatic,
which
promotes
onset
and
progression
disease.
Moreover,
advanced
insensitive
to
chemotherapy,
making
traditional
clinical
treatment
unable
block
cancer
development.
Sorafenib
(SFB)
first-line
targeted
drug
for
with
anti-angiogenesis
anti-tumor
cell
proliferation
effects.
However,
efficacy
SFB
constrained
by
its
off-target
distribution,
rapid
metabolism,
multi-drug
resistance.
In
recent
years,
nanoparticles
based
on
variety
materials
been
demonstrated
enhance
targeting
therapeutic
against
HCC.
Concurrently,
advent
joint
delivery
systems
has
furnished
crucial
empirical
evidence
reversing
This
review
will
summarize
application
nanotechnology
field
over
past
five
years.
It
focus
research
progress
combined
multiple
modalities
treatment.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 22, 2025
It
is
urgent
to
exploit
multifunctional
materials
and
combined
approaches
for
efficient
antitumor
effects.
Copper-based
metal–organic
frameworks
(Cu-MOFs)
have
excellent
performances
in
catalysis,
biocompatibility,
photothermal
conversion,
regulate
metabolism,
which
make
them
attract
more
attention
application.
Therefore,
this
review,
representative
ligands,
synthetic
methods,
mechanism,
applications
of
Cu-MOFs
were
provided.
Special
emphasis
placed
on
the
recent
drug
carriers,
therapy,
tumor
imaging,
theranostic,
are
summarized
with
examples.
Finally,
we
presented
dilemma
faced
by
offered
a
new
perspective
future
Hopefully,
review
may
serve
as
reference
further
development
application
Cu-MOFs.
