Nano Materials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Cancer
treatment
often
requires
a
multimodal
approach,
such
as
combining
chemotherapy
and
gene
therapy.
However,
challenges
low
therapeutic
efficacy
off-target
effects
hinder
the
effectiveness
of
these
treatments.
In
this
study,
use
calcium-doped
metal-organic
frameworks
Cu2(BDC)2(DABCO)
nanocarrier
platform
for
co-delivery
doxorubicin
(DOX)
plasmid
CRISPR
(pCRISPR)
proposed
to
enhance
anticancer
efficiency.
We
demonstrated
that
Ca-doped
MOF
nanocarriers
significantly
improved
uptake
DOX
pCRISPR
by
in
cancer
cells.
The
with
resulted
significant
rise
cell
death
decreased
targeted
expression.
Advances in Nanoparticles,
Год журнала:
2024,
Номер
13(03), С. 45 - 60
Опубликована: Янв. 1, 2024
Background:
Hepatocellular
carcinoma
(HCC)
is
the
most
common
type
of
liver
cancer
and
one
leading
causes
cancer-related
death
worldwide.
Advanced
HCC
displays
strong
resistance
to
chemotherapy,
traditional
chemotherapy
drugs
do
not
achieve
satisfactory
therapeutic
efficacy.
The
delivery
compounds
target
site
a
major
challenge
in
treatment
many
diseases.
Objective:
This
study
aims
evaluate
activated
charcoal
nanoparticles
as
drug
system
for
anticancer
agents
(Sorafenib
Doxorubicin)
Cancer
Stem
Cells.
Method:
percent
efficiency
entrapment
(%
EE)
doxorubicin
sorafenib
entrapped
onto
was
obtained
by
determining
free
concentration
supernatant-prepared
solutions.
Then
characterizations
were
formed
determination
particle
size
distribution,
zeta
potential,
polydispersity
index
(PDI).
activity
Charcoal,
Doxorubicin-ACNP,
sorafenib-ACNP,
doxorubicin,
solutions
measured
based
on
cell
viability
percentage
HepG2
lines
(ATCC-CCL
75).
In
vitro
RBC's
toxicity
Doxorubicin/sorafenib
loaded
estimated
hemolysis
percentage.
Results:
synthesized
Doxorubicin-ACNP
Sorafenib-ACNP
evaluated
their
physiochemical
properties
also
examined.
Essentially,
Efficiency
Entrapment
(EE
%)
found
be
87.5%
82.66%
Sorafenib-ACNP,
respectively.
loading
capacity
34.78%
24.31%
Sorafenib-ACNP.
Using
Dynamic
Light
scattering
[DLS]
hydrodynamic
surface
narrow
sample
distribution
(18,
68,
190
nm
charcoal,
105,
255,
712
91,
295,
955
sorafenib),
A
charge
−13.2,
−15.6
−17
doxorubicin/charcoal,
sorafenib/charcoal
nanoparticles.
cytotoxic
in-vitro
against
it
observed
that
Drug
ACNP
improved
when
compared
Doxorubicin
or
Sorafenib
alone.
Moreover,
testing
potential
DOX-ACNP
showed
significant
reduction
red
blood
cells
Conclusion:
conclusion,
notable
state
this
regarded
first
investigate
use
Activated
further
arena
hepatocellular
carcinoma.
noteworthy
along
with
reduced
RBCs
rendering
an
efficacious
carrier
low
potential.
Heliyon,
Год журнала:
2024,
Номер
10(14), С. e34316 - e34316
Опубликована: Июль 1, 2024
The
most
prevalent
form
of
colon
cancer
also
ranks
high
among
cancer-related
deaths
globally.
Traditional
chemotherapy
drugs
do
not
provide
sufficient
therapeutic
efficacy,
and
advanced
demonstrates
considerable
resistance
to
chemotherapy.
As
an
oral
kinase
inhibitor,
sorafenib
(SOR)
suppresses
the
growth
tumour
cells,
formation
new
blood
vessels,
death
cells.
Unfortunately,
sorafenib's
limited
bioavailability,
rapid
metabolism,
poor
solubility
have
severely
its
clinical
use.
We
developed
nanoparticles
targeting
P-selectin
SOR,
with
fucoidan
(FU)
as
a
ligand.
SOR-CS-FU-NPs
were
by
coating
polylactide-
ACS symposium series,
Год журнала:
2024,
Номер
unknown, С. 147 - 180
Опубликована: Март 5, 2024
Exploring
novel
antimicrobial
agents
has
become
increasingly
imperative
in
the
face
of
escalating
resistance.
Metal-organic
frameworks
(MOFs),
a
class
crystalline
materials
renowned
for
their
remarkable
porosity
and
versatile
functionalities,
have
emerged
as
promising
candidates
combating
microbial
infections.
This
chapter
offers
comprehensive
overview
properties
MOFs,
shedding
light
on
synthesis,
mechanisms
action,
potential
applications
diverse
fields.
Commencing
with
discussion
global
challenges
resistance,
this
underscores
urgency
innovative
approaches
research.
The
unique
attributes
including
tunable
structures
ability
to
encapsulate
bioactive
molecules
are
examined
context
designing
effective
agents.
rational
design
strategies
employed
enhance
activity
MOFs
elucidated,
encompassing
incorporation
metal
nodes,
functionalization
organic
ligands,
synergistic
combination
conventional
antibiotics.
underpinning
action
explored,
aspects
such
membrane
disruption,
reactive
oxygen
species
generation,
targeted
intracellular
delivery.
need
standardized
testing
methodologies,
in-depth
toxicity
assessments,
thorough
understanding
MOF-microbe
interactions
is
emphasized
chapter.
integration
computational
translation
laboratory
findings
practical
identified
pivotal
steps
harnessing
full
fight
against
As
healthcare
community
seeks
address
pressing
issue
stand
at
forefront,
poised
contribute
transformative
solutions
pursuit
interventions.
Nano Materials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Cancer
treatment
often
requires
a
multimodal
approach,
such
as
combining
chemotherapy
and
gene
therapy.
However,
challenges
low
therapeutic
efficacy
off-target
effects
hinder
the
effectiveness
of
these
treatments.
In
this
study,
use
calcium-doped
metal-organic
frameworks
Cu2(BDC)2(DABCO)
nanocarrier
platform
for
co-delivery
doxorubicin
(DOX)
plasmid
CRISPR
(pCRISPR)
proposed
to
enhance
anticancer
efficiency.
We
demonstrated
that
Ca-doped
MOF
nanocarriers
significantly
improved
uptake
DOX
pCRISPR
by
in
cancer
cells.
The
with
resulted
significant
rise
cell
death
decreased
targeted
expression.
