Biomedical Materials,
Год журнала:
2024,
Номер
19(5), С. 055020 - 055020
Опубликована: Июль 18, 2024
Abstract
The
majority
of
research
on
nanomaterials
has
been
concentrated
metal
nanoparticles
since
they
are
easily
made
and
manipulated.
Nanomaterials
have
shown
a
wide
range
applications
in
biology.
Nevertheless,
their
bioactivity
declines
due
to
extreme
susceptibility
novel
Se@ZIF-8
by
chemical
method.
sizes
morphologies
Se
(0)
Se@ZIFchemical
physical
stimuli.
goal
encapsulating
these
matrix
is
gradually
being
pursued,
which
boosts
affordability,
stability,
usability.
Metal-organic
frameworks,
often
known
as
MOFs,
the
potential
be
best
platforms
for
well-defined
persistent
porosity,
flexibility
modification.
In
this
investigation,
we
report
synthesis
optimization
polyvinylpyrrolidone-stabilized
Se(0)
-8
were
affected
ratios
Se/Zn
2+
[hmim]/Zn
used.
optimized
exhibited
particle
size
zeta
319
nm
−34
mv
respectively.
Transmission
electron
microscopy
displayed
spherical
morphology
nanoparticles,
whereas
surface
was
drastically
changed
hexagonal
shaped
structures
with
smooth
scanning
(SEM).
DTA,
TG/DTG,
XRD
analysis
confirmed
presence
incorporated
ZIF-8
nanoparticulate
framework.
synthesized
showed
efficient
antibacterial
activity
evidenced
low
MIC
values.
Interestingly,
NPs
not
only
inhibited
biofilm
formation
S.
marcescens,
but
also
effectively
eradicated
mature
biofilms
degrading
eDNA
EPS
layer.
It
validated
confocal
laser
SEM
analysis.
observed
that
targeted
Quroum
Sensing
pathway
reduced
its
associated
virulence
factors
production.
This
work
opens
up
different
approach
antibiotics
treat
biofilm-associated
infections
caused
marcescens
offer
solution
antimicrobial
resistance.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(8), С. 1081 - 1081
Опубликована: Июль 29, 2023
Citrus
fruits
processing
results
in
the
generation
of
huge
amounts
citrus
by-products,
mainly
peels,
pulp,
membranes,
and
seeds.
Although
they
represent
a
major
concern
from
both
economical
environmental
aspects,
it
is
very
important
to
emphasize
that
these
by-products
contain
rich
source
value-added
bioactive
compounds
with
wide
spectrum
applications
food,
cosmetic,
pharmaceutical
industries.
The
primary
aim
this
review
highlight
great
potential
isolated
phytochemicals
extracts
individual
properties
(e.g.,
antitumor,
antimicrobial,
antiviral,
antidiabetic,
antioxidant,
other
beneficial
activities
health-promoting
abilities)
their
pharmaceutical,
biomedical,
biological
applications.
This
on
contains
following
parts:
structural
chemical
characteristics;
utilization
by-products;
bioactivities
present
waxes
carotenoids,
essential
oils,
pectins,
phenolic
compounds;
by-product
formulations
enhanced
biocactivities.
A
summary
recent
developments
applying
for
treatment
different
diseases
protection
human
health
also
provided,
emphasizing
innovative
methods
bioaccessibility
enhancements
extract/component
encapsulation,
synthesis
biomass-derived
nanoparticles,
nanocarriers,
or
biofilm
preparation).
Based
representative
phytochemical
groups,
an
evaluation
studies
past
six
years
(from
2018
2023)
reporting
specific
citrus-based
provided.
Finally,
discusses
advanced
modern
approaches
pharmaceutical/biological
drug
delivery
carbon
precursors
preparation
nanoparticles
promising
antimicrobial
activity,
production
fluorescent
application
as
antitumor
agents,
cellular
imaging).
implementing
nanotechnology
food
science
biotechnology
could
bring
about
new
insights
into
providing
solutions
medical
discoveries.
Saudi Journal of Biological Sciences,
Год журнала:
2023,
Номер
30(11), С. 103820 - 103820
Опубликована: Сен. 26, 2023
Textile
dyes
and
heavy
metals
like
hexavalent
chromium
[Cr(VI)]
are
considered
major
water
pollutants.
In
addition,
microbial
contamination
also
seriously
threatens
potable
availability.
The
present
study
used
Moringa
oleifera
seed
aqueous
extract
to
synthesize
copper
nanoparticles
(MOS-CuNPs).
MOS-CuNPs
were
characterized
by
various
spectroscopy
microscopic
techniques.
shown
be
effectual
at
removal
of
Cr(VI).
initial
concentration
Cr(VI),
contact
time,
pH,
temperature
all
impacted
the
Cr(VI)
different
concentrations
MOS-CuNPs.
At
low
(0.3
mg/ml)
pseudo-first
order
high
(0.4
0.5
mg/ml),
pseudo-second
kinetics
obeyed.
Thermodynamic
analysis
revealed
that
was
removed
spontaneously,
reaction
exothermic.
adsorption
isotherm,
equilibrium
data
followed
Langmuir
equation
for
maximum
uptake
capacity
calculated
38.6
mg/g.
efficiently
cationic
(rhodamine
B,
malachite
green
methylene
blue
and)
anionic
(congo
red,
titan
yellow
methyl
orange)
within
10
min
time.
Further
showed
antimicrobial
activity
against
human
pathogenic
bacteria
fungi.
Altogether,
could
environmental
(water
treatment)
biological
applications.
Journal of drug targeting,
Год журнала:
2023,
Номер
31(9), С. 931 - 949
Опубликована: Окт. 13, 2023
AbstractBiofilms
are
complex
microbial
communities
formed
by
the
attachment
of
bacteria
or
fungi
to
surfaces
encased
in
a
self-produced
polymeric
matrix.
These
biofilms
highly
resistant
conventional
antimicrobial
therapies.
The
resistance
mechanisms
exhibited
include
low
antibiotic
absorption,
sluggish
replication,
adaptive
stress
response,
and
formation
dormant-like
phenotypes.
eradication
requires
alternative
strategies
approaches.
Nanotechnological
drug
delivery
systems
allow
excellent
control
over
chemistry,
surface
area,
particle
size,
shape,
composition
nanostructures.
Nanoformulations
can
enhance
efficacy
agents
improving
their
bioavailability,
stability,
targeted
site
infection
that
helps
biofilm
more
effectively.
In
addition
nanoformulations,
route
administration
choice
dosage
forms
play
crucial
role
treating
infections.
Systemic
antibiotics
is
effective
controlling
systemic
sepsis
associated
with
biofilms.
Alternative
routes
administration,
such
as
inhalation,
vaginal,
ocular,
dermal,
have
been
explored
target
infections
specific
organs.
This
review
primarily
examines
utilisation
nanoformulations
various
for
management.
It
also
provides
an
overview
biofilms,
current
approaches,
drawbacks
methods.Keywords:
Biofilmdrug
systemsnanoformulationdosage
formsadministration
AcknowledgementNo
funding
work
featured
this
article.Author
contributionsConceptualisation:
AK,
AYB;
Literature
Review:
All
authors;
Writing:
OS,
SC,
IB,
GA;
Editing
Reviewing:
OS;
Supervision:
AK.Disclosure
statementNo
potential
conflict
interest
was
reported
author(s).Additional
informationFundingThe
author(s)
there
no
article.
Microorganisms,
Год журнала:
2024,
Номер
12(4), С. 646 - 646
Опубликована: Март 24, 2024
Gut
microbes
play
a
vital
role
in
the
health
and
disease
of
animals,
especially
relation
to
pathogen
infections.
Chinchillas,
ferrets,
marmots
are
commonly
used
as
important
laboratory
animals
for
infectious
research.
Here,
we
studied
bacterial
fungal
microbiota
discovered
that
chinchillas
had
higher
alpha
diversity
abundance
bacteria
compared
ferrets
by
using
metabarcoding
16S
rRNA
genes
ITS2,
coupled
with
co-occurrence
network
analysis.
The
dominant
varied
significantly
among
three
animal
species,
particularly
gut
mycobiota.
In
feces
were
dominated
yeast
such
Rhodotorula
Kurtzmaniella,
while
chinchillas,
found
Teunomyces
Penicillium
dominating,
Acaulium,
Piromyces,
Kernia
marmots.
Nevertheless,
genera
shared
some
similarities,
Clostridium
Pseudomonas
across
species.
However,
there
significant
differences
observed,
Vagococcus
Ignatzschineria
Acinetobacter
Bacteroides
Cellvibrio
Additionally,
our
differential
analysis
revealed
classification
levels
different
well
variations
feeding
habitats
resulted
distinct
contributions
from
host
microbiome.
Therefore,
data
valuable
monitoring
evaluating
impacts
microbiome,
considering
potential
applications.
