Butyrate attenuates cold-induced hypertension via gut microbiota and activation of brown adipose tissue

The Science of The Total Environment, Год журнала: 2024, Номер 943, С. 173835 - 173835

Опубликована: Июнь 6, 2024

Язык: Английский

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Neuroprotective Effect of a Multistrain Probiotic Mixture in SOD1G93A Mice by Reducing SOD1 Aggregation and Targeting the Microbiota-Gut-Brain Axis

Molecular Neurobiology, Год журнала: 2024, Номер 61(12), С. 10051 - 10071

Опубликована: Фев. 13, 2024

Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the selective loss of motor neurons. A bidirectional communication system known as “microbiota-gut-brain” axis has regulatory function in disorders. The impact probiotics on ALS through remains uncertain. longitudinal investigation was conducted to examine alterations structure ileum and colon mutant superoxide dismutase 1 (SOD1 G93A ) transgenic mice models using immunofluorescence Western blotting. Subsequently, were administered multistrain probiotic mixture (LBE) or vehicle orally, starting from 60 days age until terminal stage disease. effects these agents behavior, gut microbiota, microbial metabolites, pathological processes spinal intestine SOD1 analyzed, with focus exploring potential protective mechanisms. exhibit various structural abnormalities intestine. Oral administration LBE improved proinflammatory response, reduced aberrant (SOD1) aggregation, protected neuronal cells cord mice. Furthermore, treatment resulted change intestinal an increase short-chain fatty acid levels, enhancement autophagy flux. exhibited can improve reduce protect positive effect be attributed increased acids enhanced

Язык: Английский

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MiMeJF: Application of Coupled Matrix and Tensor Factorization (CMTF) for Enhanced Microbiome-Metabolome Multi-Omic Analysis

Metabolites, Год журнала: 2025, Номер 15(1), С. 51 - 51

Опубликована: Янв. 14, 2025

Background/Objectives: The integration of microbiome and metabolome data could unveil profound insights into biological processes. However, widely used multi-omic analyses often employ a stepwise mining approach, failing to harness the full potential datasets leading reduced detection accuracy. Synergistic analysis incorporating microbiome/metabolome are essential for deeper understanding. Method: This study introduces Coupled Matrix Tensor Factorization (CMTF) framework joint data, overcoming these limitations. Two CMTF frameworks were developed factorize microbial taxa, functional pathways, metabolites latent factors, facilitating dimension reduction biomarker identification. Validation was conducted using three diverse datasets, including built environments human gut samples from inflammatory bowel disease (IBD) COVID-19 studies. Results: Our results revealed biologically meaningful biomarkers, such as Bacteroides vulgatus acylcarnitines associated with IBD pyroglutamic acid p-cresol outcomes, which provide new avenues research. consistently outperformed traditional methods in both detection, offering robust tool uncovering relevant insights. Conclusions: Despite its stringent requirements, reliance on stratified microbial-based pathway abundances taxa-level contributions, this approach provides significant step forward multi-omics analysis, applications across biomedical, environmental, agricultural

Язык: Английский

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Potential effects of indoor microbiome characteristics on health: A systematic review

Public Health, Год журнала: 2025, Номер 240, С. 137 - 147

Опубликована: Фев. 4, 2025

Язык: Английский

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A Sustainable Combined Approach to Control the Microbial Bioburden in the School Environment

Microorganisms, Год журнала: 2025, Номер 13(4), С. 791 - 791

Опубликована: Март 30, 2025

The indoor microbiome is a dynamic ecosystem including pathogens that can impact human health. In this regard, the school environment represents main living space of humans for many years, and an unhealthy significantly condition students’ School rooms suffer from insufficient ventilation use building materials may favor pathogen contamination, mostly sanitized by conventional chemical-based methods, which pollution, have temporary effects, induce selection antimicrobial resistance (AMR) in persistent microbes. search sustainable effective methods to improve healthiness classroom environment, pre–post case–control study was performed Italian high school. Over year, different interventions were sequentially placed evaluated their on bioburden air quality, introduction plants, mechanical system, probiotic-based sanitation (PBS) substitution chemical sanitation. Through continuous microbial monitoring enrolled rooms, via culture-dependent -independent remarkable level detected at baseline (around 12,000 20,000 CFU/m2, before after classes, respectively), composed Staphylococcus spp. fungi. Some decrease fungal contamination observed following plants. Still, most significant associated AMR PBS, decreased >80% (p < 0.001) up 3 Log10 compared controls. Collected data support combined strategies quality confirm PBS effectively control spread not only sanitary environments.

Язык: Английский

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How the Built Environment Shapes Children’s Microbiome: A Systematic Review

Microorganisms, Год журнала: 2025, Номер 13(4), С. 950 - 950

Опубликована: Апрель 20, 2025

This systematic review aims to synthesize key empirical findings understand how various elements of the built environment influence microbiome concerning children’s health and well-being. A comprehensive literature search was conducted across multiple databases, focusing on studies that examined relationship between factors aspects childhood. total 42 were included in final review. We analyzed these from a range different lenses, starting with basic research questions variables types environments, age groups children, sampling strategy, bioinformatics, biological methods utilized. highlights growing emphasis exposure nature within environments its potential beneficially alter microbiome, 38% addressing this link. It also identifies significant gap connecting design features (landscape and/or architectural) outcomes associated health, behavioral, mental impacts children. The indicate interventions aimed at improving quality via could foster healthier microbiomes environments. underscores need for interdisciplinary policy initiatives integrate science promote

Язык: Английский

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Exploring the role of indoor microbiome and environmental characteristics in rhinitis symptoms among university students

Frontiers in Microbiomes, Год журнала: 2024, Номер 3

Опубликована: Фев. 16, 2024

Introduction Rhinitis is one of the most prevalent chronic respiratory diseases worldwide. There emerging evidence suggesting that indoor microbiome may contribute onset and exacerbation rhinitis symptoms, but comprehensive studies on this topic remain scarce. Methods In study, we assessed assemblage settled air dust collected in Petri dishes 86 dormitory rooms Shanxi University, China using 16s rRNA sequencing. A self-administered questionnaire, including questions about symptoms personal information, was completed by 357 students residing these dormitories. Logistic linear regression model applied to examine associations between environmental characteristics, microbiome, rhinitis. Results The abundant genera dormitories were Ralstonia (15.6%), Pelomonas (11.3%), Anoxybacillus (9.3%) Ochrobactrum (6.2%). Taxa richness class Actinobacteria Fusobacteriia negatively/protectively associated with (p&lt;0.05). Six bacterial genera, those from ( Actinomyces ), Fusobacterium Bacteroidetes Prevotella Capnocytophaga Conversely, seven predominantly Alphaproteobacteria Betaproteobacteria Sphingomonas, Caulobacter , uncharacterized Caulobacteraceae Comamonadaceae positively Living higher floor level PM 2.5 concentrations a abundance taxa potentially protective against lower increasing risk (P&lt;0.01). However, having curtain CO 2 Discussion This study enhances our understanding complex interactions microbiomes, rhinitis, shedding light potential strategies manipulate for disease prevention control.

Язык: Английский

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Global meta‐analysis reveals the drivers of gut microbiome variation across vertebrates

iMetaOmics., Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Abstract Shifts in gut microbial diversity and structure are one route by which vertebrate hosts adapt to local environmental conditions. However, recent studies have mostly been limited a single species, small sample sizes, or restricted geographic ranges. Therefore, drawing global picture of microbiome diversity, community structure, determinants for their adaptive shifts remains be elucidated. We here collected 6508 samples from 113 species covering diverse classes, feeding behaviors, host habitats based on 16S rRNA gene sequencing. The results showed that diet pattern had significant impact variation, might drive taxonomic functional contents across vertebrates. Of note, the phylum Fusobacteria were enriched carnivorous while herbivorous selectively increased abundance Verrucomicrobia. Also, climate factors strongly associated with variation Interestingly, we found microbiota belonging Bacteroidetes gradually members Proteobacteria decreasing trend high‐ low‐latitude zones, potentially contributing adaptation condition. Additionally, comprehensively deciphered common antibiotic resistomes potential mobility between terrestrial ( n = 487) sympatric soil biological environment 203) integrating metagenomic sequencing datasets. Particularly, horizontal resistance genes (e.g., bacA ) transfers detected vertebrates environment. Together, our findings provide new evidence how external affect variation.

Язык: Английский

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Childcare centre soil microbiomes are influenced by substrate type and surrounding vegetation condition

The Science of The Total Environment, Год журнала: 2024, Номер 927, С. 172158 - 172158

Опубликована: Апрель 5, 2024

Urban development has profoundly reduced human exposure to biodiverse environments, which is linked a rise in disease. The 'biodiversity hypothesis' proposes that contact with diverse microbial communities (microbiota) benefits health, as diversity promotes immune training and regulates function. Soils sandpits urban childcare centres may provide microbiota support immunoregulation at critical developmental stage child's life. However, the influence of outdoor substrate (i.e., sand vs. soil) surrounding vegetation on these environmental remains poorly understood. Here, we used 16S rRNA amplicon sequencing examine variation bacterial soils across 22 Adelaide, Australia, plus impact plant species richness habitat condition communities. We show had distinct lower alpha than soils. In addition, found centres' yards influenced but not sandpits. These results demonstrate composition centre sandpit soil are shaped by type, also within centres. Accordingly, there potential modulate children health-associated managing substrates around

Язык: Английский

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Childcare Centre Soil Microbiomes are Influenced by Substrate Type and Surrounding Vegetation Condition

Опубликована: Янв. 1, 2024

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Язык: Английский

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