New Biotechnology,
Год журнала:
2023,
Номер
78, С. 76 - 83
Опубликована: Окт. 10, 2023
Antibody
therapeutics
show
great
potential
to
treat
a
variety
of
diseases.
Often,
the
dose
that
can
be
safely
administered
is
limited
by
side
effects
arise
from
interaction
with
target
outside
diseased
tissue.
Conditionally-active
antibodies
provide
an
additional
layer
selectivity
improve
safety.
Distinct
external
stimuli
or
internal
cues
enable
different
control
strategies
and
applications.
However,
current
antibody
masking
have
low
transferability
across
stimuli.
Here
we
propose
versatile
approach
conditionally
mask
derivatives
its
application
single
chain
variable
fragment
(scFv)
against
receptor
expressed
on
cancer
stem
cells
in
several
tumours.
Our
strategy
relies
site-specific
conjugation
polymer
engineered
cysteine
residue
through
chemically-synthesised
linker
cleaved
response
stimulus.
We
efficiency
depends
site
size
mask.
An
optimised
decreases
antigen
binding
up
20-fold
affinity
fully
recovered
upon
activation
exposure
light
at
365
nm
incubation
matrix
metalloproteinases
overexpressed
solid
This
opens
possibility
rapidly
engineer
activatable
any
RSC Advances,
Год журнала:
2024,
Номер
14(29), С. 20609 - 20645
Опубликована: Янв. 1, 2024
The
photocatalytic
field
revolves
around
the
utilization
of
photon
energy
to
initiate
various
chemical
reactions
using
non-adsorbing
substrates,
through
processes
such
as
single
electron
transfer,
or
atom
transfer.
Nano Materials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 1, 2024
The
field
of
photocatalysis
has
witnessed
a
significant
advancement
in
the
development
bioinspired
and
biomimetic
photocatalysts
for
various
biomedical
applications,
including
drug
delivery,
tissue
engineering,
cancer
therapy,
bioimaging.
Nature
evolved
efficient
light-harvesting
systems
energy
conversion
mechanisms,
which
serve
as
benchmark
researchers.
However,
reproducing
such
complexity
harnessing
it
applications
is
daunting
task.
It
requires
comprehensive
understanding
underlying
biological
processes
ability
to
replicate
them
synthetically.
By
utilizing
light
energy,
these
can
trigger
specific
chemical
reactions,
leading
targeted
release,
enhanced
regeneration,
precise
imaging
structures.
In
this
context,
addressing
stability,
long-term
performance,
scalability,
cost-effectiveness
materials
crucial
their
widespread
implementation
applications.
While
challenges
stability
persist,
advantages
delivery
personalized
medicine
make
fascinating
area
research.
purpose
review
provide
analysis
evaluation
existing
research,
highlighting
advancements,
current
challenges,
advantages,
limitations,
future
prospects
biomedicine.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 1, 2025
The
rapid
development
of
nanotechnology
has
significantly
advanced
the
application
nanophotocatalysis
in
medical
field,
particularly
for
cancer
therapy.
Traditional
treatments,
such
as
chemotherapy
and
radiotherapy,
often
cause
severe
side
effects,
including
damage
to
healthy
tissues
drug
resistance.
In
contrast,
nanophotocatalytic
therapy
offers
a
promising
approach
by
utilizing
nanomaterials
that
generate
reactive
oxygen
species
(ROS)
under
light
activation,
allowing
precise
tumor
targeting
minimizing
collateral
surrounding
tissues.
This
review
systematically
explores
latest
advancements
highly
efficient
nanophotocatalysts
treatment,
focusing
on
their
toxicological
profiles,
underlying
mechanisms
cell
eradication,
potential
clinical
application.
Recent
research
shows
nanophotocatalysts,
TiO2,
In2O3,
g-C3N4
composites,
along
with
photocatalysts
high
conduction
band
or
valence
positions,
ROS
irradiation,
which
induces
oxidative
stress
leads
apoptosis
necrosis.
These
cellular
interacting
key
biological
molecules
DNA,
proteins,
lipids,
triggering
cascade
biochemical
reactions
ultimately
result
death.
Furthermore,
strategies
S-scheme
heterojunctions
vacancies
(OVs)
have
been
incorporated
enhance
charge
separation
efficiency
absorption,
resulting
increased
generation,
improves
photocatalytic
performance
targeting.
Notably,
these
exhibit
low
toxicity
cells,
making
them
safe
effective
treatment
modality.
also
discusses
challenges
associated
therapy,
limitations
penetration
need
improved
biocompatibility.
findings
suggest
technology
holds
significant
precision
paving
way
safer
more
strategies.
Advances in chemical and materials engineering book series,
Год журнала:
2024,
Номер
unknown, С. 213 - 240
Опубликована: Окт. 22, 2024
Polymer
nanocomposites
and
nanostructured
polymers
represent
a
transformative
frontier
in
materials
science,
merging
with
nanoscale
fillers
to
enhance
mechanical,
thermal,
barrier
properties.
This
chapter
delves
into
the
synthesis,
characterization,
applications
of
these
advanced
materials,
highlighting
their
unique
structural
attributes
multifunctional
capabilities.
By
examining
various
nanofillers
such
as
carbon
nanotubes,
graphene,
nanoparticles,
elucidates
role
improving
polymer
matrix
Key
topics
include
fabrication
techniques,
interfacial
interactions,
impact
nano
structuring
on
material
performance.
The
also
explores
burgeoning
fields
aerospace,
automotive,
electronics,
biomedical
engineering,
emphasizing
potential
revolutionize
product
design
functionality.
aims
provide
foundational
understanding
principles
progress
field
polymers.
