Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 9, 2023
Abstract
Escitalopram
(ETP)
has
poor
oral
bioavailability
due
to
its
low
water
solubility,
hence
the
goal
of
this
work
was
design
and
optimize
a
self-nano-emulsifying
drug
delivery
system
(SNEDDS).
Using
results
investigations
on
solubility
emulsification,
pseudo-ternary
phase
diagram
produced.
The
three
main
ingredients
chosen
for
formulation
were
polyethylene
glycol
400
(co-surfactant),
tween
80
(surfactant),
geranium
oil
(lipid).
ETP-SNEDDS
evaluated
size
particles
surface
charge.
Fourier
transforms
infrared
spectroscopy
(FTIR),
differential
scanning
calorimetry
(DSC)
thermogravimetric
analysis
(TGA)
used
evaluate
chemical
compatibility
thermal
stability.
Ex-vivo
permeability,
in
vitro
digestion,
dissolution
carried
out
compared
with
reference
tablets.
ETP-loaded
SNEDDS
comparison
control
Wistar
rats
(n
=
6).
With
droplet
145
nm,
polydispersity
index
0.120,
an
emulsification
period
almost
one
minute,
synthesized
thermodynamically
stable.
displayed
96%
FSSIF.
permeation
investigation
revealed
that,
ETP
powder
tablet,
respectively,
increased
penetration
by
4.2
3.1-folds.
enhancement
dissolution,
ex-vivo
permeability
found
significant
(p
<
0.05).
In
reference,
had
C
max
AUC
increases
5.34
4.71
fold,
respectively.
These
findings
suggested
that
would
be
promising
method
increasing
absorption
ETP.
Journal of Pharmacy And Bioallied Sciences,
Год журнала:
2024,
Номер
16(Suppl 2), С. S1195 - S1197
Опубликована: Апрель 1, 2024
A
BSTRACT
Dextrose
cross-linked
glutaraldehyde
hydrogels
are
effective
and
promising
drug
delivery
candidates.
The
addition
of
chitosan
with
dextrose
resulted
in
the
polymerization
material
which
production
a
gel-like
structure
that
was
highly
viscous
had
gelling
properties.
swelling
absorption
assay
conducted
on
hydrogel.
hydrogel
has
higher
potential
for
distilled
water
followed
by
PBS
least
observed
ethanol.
favors
solubility
as
compared
to
other
solvents.
amoxicillin
release
then
tested.
result
from
demonstrates
released
more
than
55%
2
hours
remaining
portion
remaining.
Therefore,
it
slow
drug-release
property,
can
be
used
further
wound-healing
studies.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(17), С. 21191 - 21199
Опубликована: Авг. 22, 2024
Manganese
dioxide
(MnO2)
nanosheets
with
a
well-defined
2D
structure
can
serve
as
catalase
(CAT)
and
superoxide
dismutase
(SOD)
mimics
hold
high
potential
in
regulating
the
oxidative
stress
of
atopic
dermatitis
(AD).
However,
facile,
time-saving,
scalable
synthesis
high-activity
MnO2
is
still
challenging.
Here,
we
report
one-step
strategy
explore
its
CAT
SOD
to
exert
antioxidant
functions.
After
further
gelatinization
by
integrating
into
poly(ethylene
glycol)diacrylate
(PEGDA)
polymer
(PGM
hydrogel),
obtained
PGM
hydrogel,
characterized
well-designed
cross-linking
density
moisture
retention,
retains
antioxidation
cytoprotection
ability.
In
AD-bearing
mouse
models,
hydrogel
facilitates
recovery
impaired
mice
skin,
reducing
severity
score,
scratching
numbers,
epidermal
thickness,
immune
factors,
including
mast
cells,
IgE
antibodies,
inflammatory
cytokines
IL-4
IL-10.
Such
simple
reliable
approach
paves
way
for
scale
practical
application
antioxidative
immunoregulation
agents
AD
therapy.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 9, 2023
Abstract
Escitalopram
(ETP)
has
poor
oral
bioavailability
due
to
its
low
water
solubility,
hence
the
goal
of
this
work
was
design
and
optimize
a
self-nano-emulsifying
drug
delivery
system
(SNEDDS).
Using
results
investigations
on
solubility
emulsification,
pseudo-ternary
phase
diagram
produced.
The
three
main
ingredients
chosen
for
formulation
were
polyethylene
glycol
400
(co-surfactant),
tween
80
(surfactant),
geranium
oil
(lipid).
ETP-SNEDDS
evaluated
size
particles
surface
charge.
Fourier
transforms
infrared
spectroscopy
(FTIR),
differential
scanning
calorimetry
(DSC)
thermogravimetric
analysis
(TGA)
used
evaluate
chemical
compatibility
thermal
stability.
Ex-vivo
permeability,
in
vitro
digestion,
dissolution
carried
out
compared
with
reference
tablets.
ETP-loaded
SNEDDS
comparison
control
Wistar
rats
(n
=
6).
With
droplet
145
nm,
polydispersity
index
0.120,
an
emulsification
period
almost
one
minute,
synthesized
thermodynamically
stable.
displayed
96%
FSSIF.
permeation
investigation
revealed
that,
ETP
powder
tablet,
respectively,
increased
penetration
by
4.2
3.1-folds.
enhancement
dissolution,
ex-vivo
permeability
found
significant
(p
<
0.05).
In
reference,
had
C
max
AUC
increases
5.34
4.71
fold,
respectively.
These
findings
suggested
that
would
be
promising
method
increasing
absorption
ETP.
