Antibiotic resistance genes (ARGs) in microorganisms and their indications for the nitrogen/sulfur cycle in the East China Sea sediments

Journal of Hazardous Materials, Год журнала: 2025, Номер 488, С. 137280 - 137280

Опубликована: Янв. 20, 2025

Язык: Английский

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ARGfore: A multivariate framework for forecasting antibiotic resistance gene abundances using time-series metagenomic datasets

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Abstract Background The global spread of antibiotic resistance presents a significant threat to human, animal, and plant health. Metagenomic sequencing is increasingly being utilized profile genes (ARGs) in various environments, but presently mechanism for predicting future trends ARG occurrence patterns lacking. Capability forecasting abundance could be extremely valuable towards informing policy practice aimed at mitigating the evolution ARGs. Results Here we propose ARGfore, multivariate model abundances from time-series metagenomic data. ARGfore extracts features that capture inherent relationships among ARGs trained recognize seasonality. Conclusion outperformed standard methods, such as N-HiTS, LSTM, ARIMA, exhibiting lowest mean absolute percentage error when applied different wastewater datasets. Additionally, demonstrated enhanced computational efficiency, making it promising candidate variety surveillance applications. rapid prediction can facilitate early detection deployment mitigation efforts if necessary. publicly available https://github.com/joungmin-choi/ARGfore .

Язык: Английский

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Các liệu pháp phòng, trị bệnh mới trong nuôi trồng thủy sản

Can Tho University Journal of Science, Год журнала: 2025, Номер 61(1)

Опубликована: Фев. 18, 2025

Sự mở rộng về quy mô của nghề nuôi trồng thủy sản đã dẫn đến dịch bệnh phát sinh ngày một phức tạp hơn. Trong khi đó, việc lạm dụng thuốc kháng để giải quyết gia tăng tình trạng thuốc, khiến các loại mạnh nhất càng mất hiệu quả. Việc tập trung nghiên cứu pháp thay thế bền vững, sáng tạo trong điều trị sẽ ra giai đoạn mới sức khỏe sản. Bài báo này nhằm mục đích tổng hợp và đánh giá số liệu mới, tiên tiến kiểm soát truyền nhiễm hiện nay. Các như thực khuẩn thể, endolysin, bacteriocin quorum quenching đang chứng minh được quả vượt trội cùng với tính an toàn cao. Bên cạnh peptide khuẩn, thể IgY, hạt nano cũng mang lại những định cho

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Composition, Distribution and Mobility Potential of the Antibiotic Resistome in Sediments from the East China Sea Revealed by Metagenomic Analysis

Microorganisms, Год журнала: 2025, Номер 13(3), С. 697 - 697

Опубликована: Март 20, 2025

Marine sediments are recognized as crucial reservoirs of antibiotic resistance genes (ARGs). However, the resistome in East China Sea, an area heavily impacted by human activities, has not been thoroughly studied. Here, we conducted a systematic investigation into these using metagenomic analysis. Overall, detected eighty ARG subtypes and nineteen types. Beta-lactams were dominant type, Gammaproteobacteria was main host this study. Mobile genetic elements (MGEs) major drivers profiles. Although communities significantly differed between spring autumn (p < 0.05), remained stable across two seasons. The assembly ARGs their hosts governed stochastic processes, high ratio processes implied its role stabilization resistome. Co-occurrence network analysis revealed important Deltaproteobacteria profiles Environmental parameters (e.g., temperature density) played certain roles autumn. Moreover, nine pathogen bacteria (HPB) We also found that health risks caused relatively higher spring. Our results will provide strong foundation for development targeted management strategies to mitigate further dissemination spread marine sediments.

Язык: Английский

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Global perspectives on residual antibiotics: environmental challenges and trends

Discover Sustainability, Год журнала: 2025, Номер 6(1)

Опубликована: Апрель 1, 2025

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Global quantification and distribution of antibiotic resistance genes in oceans and seas: Anthropogenic impacts and regional variability

The Science of The Total Environment, Год журнала: 2024, Номер 955, С. 176765 - 176765

Опубликована: Окт. 10, 2024

The global spread of antibiotic resistance genes (ARGs) in the marine environment poses a significant threat to public health and natural ecosystems. This study quantified analysed distribution co-occurrence patterns ARGs wide range oceans high seas, including Atlantic, Arctic Indian Ocean, Mediterranean Sea Persian Gulf. Focusing on beta-lactamases (bla

Язык: Английский

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