Food systems,
Год журнала:
2024,
Номер
7(3), С. 384 - 393
Опубликована: Окт. 22, 2024
The
release
of
pollutants
into
the
environment
is
a
serious
ecological
problem
due
to
significant
risks
they
pose
both
ecosystems
and
human
health.
review
considers
issues
detection
distribution
new
pollutants,
as
well
sources
their
entry
potential
impact
on
ecosystems.
wastewater
pollution
especially
urgent
in
context
conservation
salmonid
fish
species.
Pharmaceutical
veterinary
drugs,
components
personal
hygiene
products,
microplastics,
per-
polyfluorinated
substances,
brominated
flame
retardants,
oil
number
other
toxicants
enter
freshwater
bodies,
which
are
important
for
early
stages
salmon
development
its
following
migration.
presence
aquatic
depends
source,
ability
bioaccumulate,
degrade
processes
biological
abiotic
purification.
High-resolution
mass
spectrometry
combination
with
gas
or
liquid
chromatography
can
be
recommended
pollutants.
Due
high
measurement
accuracy
specificity,
this
method
able
effectively
identify
even
complex
matrix.
When
conducting
non-targeted
targeted
screening
highly
sensitive
full
scanning,
it
advisable
use
high-resolution
analyzers
(TOF,
Q-TOF,
Q-Orbitrap),
allow
determining
compounds.
A
promising
direction
assessment
species
identification
indicators
characterizing
metabolomics.
It
based
study
low-molecular
organic
compounds
—
metabolites,
intermediate
final
metabolic
products
body
fluids
tissues.
Metabolomic
profiling
allows
identifying
markers
state
water
under
influence
necessary
comprehensive
regulations
guidelines
effective
handling
these
As
a
subclass
of
microplastics,
tire
and
road
wear
particles
have
been
recognized
as
source
toxicants
in
the
aquatic
environment.
Tire
rubber
contains
chemicals
associated
with
serious
toxicological
effects,
especially
some
salmonid
species,
but
not
other
fish
species.
Among
these
are
polynuclear
aromatic
hydrocarbons
(PAHs)
6PPD-Q.
These
detoxified
excreted
through
enzymatic
biotransformation,
notably
by
cytochrome
P-450
(CYP)
isoforms
UDP-glucuronosyltransferases
(UGT).
We
tested
hypothesis
that
species
differences
activity
enzymes
is
responsible
for
sensitivity
to
PAHs
Three
trout
(rainbow
trout,
brook
brown
trout)
were
exposed
100-250
mg/L
micronized
96h
exposures,
after
which
CYP1A
was
measured
EROD
assay,
phenol-type
UGT
1-naphthol
both
liver
gill
tissue.
Bile
fluorescence
indicator
uptake
excretion
PAHs.
The
results
showed
activities
gills
much
lower
than
liver,
would
explain
observed
behavioral
toxicity
mortality
this
during
exposure.
In
significantly
upregulated
rainbow
gills.
Comparison
data
from
demonstrated
relatively
low
expression,
which,
combined
activity,
supports
PAH
6PPD-Q
determined
expression
detoxification
enzymes.
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
290, С. 117744 - 117744
Опубликована: Янв. 1, 2025
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine
(6PPD),
a
synthetic
additive
widely
used
in
the
rubber
industry,
and
its
oxidized
product
6PPD-quinone
(6PPDQ),
have
garnered
widespread
attention
as
an
emerging
hazardous
chemicals
owing
to
their
potential
detrimental
effects
on
aquatic
ecosystem
human
health.
The
of
6PPD
6PPDq
female
reproductive
tract,
especially
embryo
implantation,
remain
unknown
were
investigated
this
study.
We
spheroid
attachment
outgrowth
models
BeWo
trophoblastic
spheroids
Ishikawa
cells
surrogates
for
blastocyst
endometrial
epithelium,
respectively.
Treatment
with
up
48
h
decreased
viability
dose-
cell
line-dependent
manner
(20-100
μM
10-100
6PPDQ
both
lines).
At
noncytotoxic
concentration,
exposure
1
10
reduced
further
inhibited
invasion
epithelial
monolayer.
A
similar
result
was
observed
6PPDQ-exposed
groups.
Gene
expression
profiling
6PPD-
revealed
that
differentially
regulated
panel
transcript
markers
toward
overall
downregulation
receptivity
invasion.
study
provides
first
proof
adverse
trophoblast
during
window
warranting
need
vivo
clinical
studies.
Fishes,
Год журнала:
2025,
Номер
10(4), С. 146 - 146
Опубликована: Март 25, 2025
N-(1,3-dimethylbutyl)-N’-phenyl-p-benzoquinone
(6PPD-Q)
is
an
emerging
environmental
contaminant
that
widely
distributed
in
aquatic
environments
and
presents
significant
toxicological
risks
to
organisms.
As
6PPD-Q
primarily
derived
from
oxidative
transformation
of
the
tire
antioxidant
N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine
(6PPD),
its
persistence
potential
for
bioaccumulation
organisms
have
raised
widespread
concerns.
This
study
reviews
sources,
spatial
distribution,
migration,
behaviors
6PPD-Q,
as
well
degradation
mechanisms
different
media.
Additionally,
this
review
systematically
explores
effects
on
organisms,
including
physiological,
biochemical,
molecular
impacts
fish,
crustaceans,
mollusks,
algae,
with
a
focus
mechanisms.
Finally,
we
discuss
limitations
current
research
propose
key
directions
future
studies,
long-term
ecological
risk
assessments,
bioaccumulation,
metabolic
pathway
analysis,
optimization
pollution
control
strategies,
aiming
provide
scientific
basis
assessment
management
6PPD-Q.
