Microplastics and Nanoplastics Increase Major Adverse Cardiac Events in Patients with Myocardial Infarction

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137624 - 137624

Опубликована: Фев. 19, 2025

Microplastics and nanoplastics (MNPs) have implicated in cardiovascular disease preclinical studies. Our objective is to investigate the relationship between MNPs coronary arteries major adverse cardiac events (MACE) patients with myocardial infarction (MI).We conducted a prospective observational study involving undergoing angiography for MI. Coronary blood samples were analyzed presence of using pyrolysis-gas chromatography-mass spectrometry. A total 142 enrolled, 110 completing 31.5-month follow-up. Among them, 48 (43.6 %) had detectable polystyrene, 79 (71.8 polyethylene, 105 (95.4 polyvinyl chloride (PVC), 68 (61.8 polyamide 66 their blood. PVC concentration was higher who experienced MACE. Furthermore, levels positively associated proinflammatory factors (IL-1β, IL-6, IL-18, TNF-α), odds MACE (OR: 1.090, 95 %CI: 1.032-1.1523, P = 0.002). Notably, each 10-unit increase PVC, there 1.374-fold risk (OR=2.374, 1.366-4.128, Additionally, we collected thrombus from an additional 21 MI patients, finding that thrombi correlated inflammatory markers monocyte/macrophage infiltration.

Язык: Английский

Microplastics induce toxic effects in fish: Bioaccumulation, hematological parameters and antioxidant responses

Chemosphere, Год журнала: 2025, Номер 375, С. 144253 - 144253

Опубликована: Фев. 28, 2025

Язык: Английский