Latent class analysis identifies risk groups to model the expected benefits of SARS-CoV-2 interventions among university students
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 2, 2025
Non-pharmaceutical
public
health
measures
(PHMs)
were
central
to
pre-vaccination
efforts
reduce
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
exposure
risk;
heterogeneity
in
adherence
placed
bounds
on
their
potential
effectiveness,
and
correlation
adoption
makes
assessing
the
impact
attributable
an
individual
PHM
difficult.
During
Fall
2020
semester,
we
used
a
longitudinal
cohort
design
university
student
population
conduct
behavioral
survey
of
intention
adhere
PHMs,
paired
with
IgG
serosurvey
quantify
SARS-CoV-2
at
end
semester.
Using
latent
class
analysis
responses,
identified
three
distinct
groups
among
673
students
samples:
256
(38.04%)
most
adherent
group,
intending
follow
all
guidelines,
306
(46.21%)
moderately-adherent
111
(15.75%)
least-adherent
rarely
any
measure,
negatively
correlated
seropositivity
25.4%,
32.2%
37.7%,
respectively.
Moving
individuals
SIR
model
into
group
resulted
77-96%
reduction
seroprevalence,
dependent
assumed
assortativity.
The
increasing
was
limited
by
substantial
risk
large
proportion
already
following
PHMs.
Язык: Английский
Clinical and regulatory development strategies for GBS vaccines intended for maternal immunisation in low- and middle-income countries
Vaccine,
Год журнала:
2025,
Номер
58, С. 127131 - 127131
Опубликована: Май 13, 2025
Group
B
Streptococcus
(GBS)
is
a
leading
cause
of
infant
mortality,
particularly
in
low-
and
middle-income
countries
(LMICs).
Several
maternal
GBS
vaccine
candidates,
aimed
at
protecting
infants,
are
progressing
through
clinical
trials.
The
World
Health
Organisation
(WHO)
aims
to
ensure
equitable
access
safe,
effective,
affordable
vaccines
assured
quality
LMICs,
by
facilitating
regulatory
pathways.
An
alternate
approval
pathway,
based
on
safety
an
immunological
endpoint
thought
predict
benefit
(commonly
referred
as
serological
threshold
risk
reduction
[SToRR]),
being
considered
for
vaccines.
Since
this
approach
new
many
LMICs
regulators
policymakers,
WHO
organized
consultative
meetings
national,
regional,
global
levels
discuss
the
feasibility
potential
challenges
approving
immunogenicity
data
alone.
These
consultations
focused
evidence
supporting
SToRR,
their
use
endpoints
infer
protection,
post-licensure
requirements.
aim
was
reduce
delay
between
development,
licensure,
policy
recommendations
high-burden
LMICs.
Язык: Английский
An integrative review of the combined use of mathematical and statistical models for estimating malaria transmission parameters
Malaria Journal,
Год журнала:
2025,
Номер
24(1)
Опубликована: Май 30, 2025
Characterizing
malaria
burden
and
its
evolution
is
complicated
by
the
high
levels
of
spatio-temporal
heterogeneity
complexity
transmission
process.
This
manuscript
presents
an
integrative
review
combined
use
mathematical
statistical
models
to
estimate
parameters.
Therefore,
this
work
aims
provide
a
solid
methodological
foundation
for
estimation
intensity
other
relevant
quantities.
A
perspective
covering
both
appraise
commonly
used
metrics
adopted
subsequently
their
inclusion
as
parameters
in
compartmental
well
from
available
data
discussed.
The
current
argues
favour
more
widespread
consideration
Force
Infection
(FOI)
metric.
Using
FOI
dispenses
analyst
explicitly
describing
vector
dynamics
modelling,
simplifying
system
differential
equations
dynamics.
In
turn,
can
be
flexibly
performed
solely
relying
on
host
data,
such
parasitaemia
or
serology,
avoiding
need
entomological
data.
present
that
interaction
between
models,
although
previously
exemplified
others,
underappreciated
when
modelling
transmission.
Orienting
exposition
around
provides
illustration
potential
borne
existing
methodology.
connection
two
frameworks
warrants
better
scrutiny,
it
leads
possibility
exploiting
full
range
modern
methods.
Язык: Английский