An update on promising and emerging protein kinase B/AKT inhibitors for breast cancer
Expert Opinion on Pharmacotherapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Introduction
.
The
PI3K
pathway
is
crucial
in
breast
cancer
(BC),
influencing
cell
survival,
growth,
and
metabolism,
with
AKT
playing
a
central
role
treatment
resistance.
This
pathway's
involvement
carcinogenesis
its
link
to
resistance
underscores
the
significance
of
targeting
it
BC
therapy.
PI3K-pathway
inhibitors
offer
new
therapeutic
avenues
but
bring
challenges,
especially
due
toxicity
issues
that
hinder
their
development.
Язык: Английский
Metastasis-directed stereotactic radiotherapy and systemic treatment continuation for patients with oligoprogressive metastatic breast cancer
European Journal of Cancer,
Год журнала:
2024,
Номер
215, С. 115164 - 115164
Опубликована: Дек. 6, 2024
Язык: Английский