Insights into mode of action mediated responses following pharmaceutical uptake and accumulation in plants

Frontiers in Agronomy, Год журнала: 2024, Номер 5

Опубликована: Янв. 15, 2024

The reuse of wastewater to meet irrigation requirements and slurries, sludges manures as fertilisers crop nutrient demands inadvertently introduces human veterinary-use pharmaceuticals into the agro-ecosystem. This review synthesises recent research, which has observed sub-lethal effects, following pharmaceutical uptake by plants. Potential links between mode action effects in plant were then examined. Common receptors biological pathways across species suggests a clear need integrate cellular biology our understanding impacts on important functions processes. To help prioritise future research efforts an analysis shared mammalian biochemical was undertaken identify classes may present greater risk key functions. These included sulfonylurea antihyperglycemics, steroids, opiods, antipsychotic phenothiazines targeting several neurotransmitters mammals plants (including beta-blockers, antihistamines benzodiazepines). Whilst number induced have been observed, this highlights study wider range broader species, including cover crops wild plants, under realistic exposure scenarios, fully understand implications agro-ecosystems. State-of-the art omics-techniques offer great potential elucidate intended effects. In addition, studies co-stress from other stressors such increased temperatures, drought or pests are lacking urgent face feeding growing population threats climate change.

Язык: Английский

---

The direct targets of metformin in diabetes and beyond

Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

---

The Effects of Single and Combined Stressors on Daphnids—Enzyme Markers of Physiology and Metabolomics Validate the Impact of Pollution

Toxics, Год журнала: 2022, Номер 10(10), С. 604 - 604

Опубликована: Окт. 12, 2022

The continuous global increase in population and consumption of resources due to human activities has had a significant impact on the environment. Therefore, assessment environmental exposure toxic chemicals as well their biological systems is importance. Freshwater are currently under threat monitored; however, current methods for pollution can neither provide mechanistic insight nor predict adverse effects from complex pollution. Using daphnids bioindicator, we assessed acute exposures eight individual specifically two metals, four pharmaceuticals, pesticide stimulant, composite mixture combining phenotypic, biochemical metabolic markers physiology. Toxicity levels were same order magnitude significantly enhanced mixture. Results showed distinct responses key enzyme such phosphatases, lipase, peptidase, β-galactosidase glutathione-S-transferase. Following this, more realistic scenario was with aforementioned metabolomic approach. A clear dose-dependent effect validated physiology, analysis verified observed, thus providing sensitive metrics metabolite perturbations. Our study highlights that be used advance design holistic assays guide selection trajectory study, while insight. In future this could prove become useful tool understanding predicting freshwater

Язык: Английский

---

Acute and chronic ecotoxicological effects of pharmaceuticals and their mixtures in Daphnia similis

Chemosphere, Год журнала: 2022, Номер 309, С. 136671 - 136671

Опубликована: Окт. 6, 2022

Язык: Английский

---

Pharmaceuticals and Personal Care Products and Heavy Metals in the Ganga River, India: Distribution, Ecological and Human Health Risk Assessment

Environmental Research, Год журнала: 2024, Номер unknown, С. 119993 - 119993

Опубликована: Сен. 1, 2024

Язык: Английский

---